Background:Although there are several assessments that directly measure adaptive behavior, other comprehensive measures include adaptive behavior scales, including the Behavioral Assessment System for Children-Second Edition Parent Rating Scale (BASC-2-PRS). Methods: BASC-2-PRS data from 19 individuals diagnosed with autism spectrum disorders were analyzed to determine score discrepancies between diagnoses [autistic disorder, Asperger ' s syndrome (AS), and pervasive developmental disorder-not otherwise specified (PDD-NOS)] on the adaptive behavior profiles on this measure. Differences were hypothesized to correlate with diagnostic intensity (autistic disorder, including the most intense characteristics, followed by AS, and then PDD-NOS). Communication sub-scores of the adaptive behavior scale were expected to be significantly lower for the group with autism than the two other groups. Results: Results indicated significant differences between diagnoses on the adaptability subscale. Differences in cluster score patterns in relation to diagnosis were also observed in the areas of Social Skills and Communication. Interestingly, ratings of the ability to engage in activities of daily living were more often the highest subscale for those with autistic disorder than those with AS or PDD-NOS. Conclusions: The utility of the BASC-2 adaptive behavior scale is discussed in this context.