Patterns and Determinants of Essential and Toxic Elements in Chinese Women at Mid-Pregnancy, Late Pregnancy, and Lactation

Zhou, Yubo; Yan, Lailai; Li, Hongtian; Li, Xiucui; Liu, Yaqiong; Liu, Jianmeng

doi:10.3390/nu13020668

Cited by 7 publications

(5 citation statements)

References 44 publications

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“…Pregnancy has been demonstrated to increase women’s health risks and vulnerability to environmental toxins. [ 15 16 ]…”

Section: Discussionmentioning

confidence: 99%

Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital

Sahu,

Yogeshbhai,

Oza

et al. 2024

Journal of Family Medicine and Primary Care

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Background and Aim: With the growth of the world’s economy and industrialization, lead (Pb) contamination in the environment has become a major issue on a global scale. Lead is typically linked to unfavorable pregnancy outcomes such as stillbirth, low birth weight preterm, and spontaneous abortion. In this study, we evaluated the blood lead levels of pregnant women and their birth outcomes attending an Indian tertiary care teaching hospital, those who were not exposed to any lead-associated industry or shops. Methods: A descriptive study was undertaken to evaluate blood lead estimation in pregnant women and umbilical blood lead levels in a community hospital. Blood samples from 104 mothers during the 1st trimester, 90 mothers during 3rd trimester, and from the umbilical cord were collected. Self-administered questionnaires were used to collect information on demographics, medical history, and concerns linked to pregnancy. Following acid digestion, the levels of lead in whole blood were determined by an atomic absorption spectrometer. The DNA damage in high blood lead-concentrated pregnant women was evaluated by comet assay methods. Results: Among 194 blood samples of pregnant women, 31 (15.98%) samples revealed ≥5 μg/dL blood lead levels. High lead concentration (≥5 µg/dL) in 1st trimester pregnant women, end of 3rd trimester and cord blood were detected 20.19%, 11.11% and 1.11% respectively. The mean blood lead levels in 1st trimester, 3rd trimester, and cord blood were 3.88 ± 3.19, 2.66 ± 1.82, and 1.53 ± 1.06 mg/dL, respectively. The blood lead concentrations were significantly higher in the 1st trimester of pregnancy than in the 3rd trimester of pregnancy (P < 0.0017). A positive correlation between maternal and infant blood lead levels was revealed (P < 0.0001). When the comet assay was used to assess the genotoxic consequences of elevated blood lead levels during pregnancy, higher amounts of DNA damage were found in the samples (P < 0.01). Conclusion: In this descriptive study, there was a significant amount of lead transferred from mother to baby through the placenta. All mothers were not exposed to lead-associated industry and most were housewives. This article may be viewed as an eye-opener for understanding the blood lead concentration during pregnancy to avoid abnormal birth outcomes. To minimize exposure to environmental lead, all possible measures should be undertaken.

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“…Pregnancy has been demonstrated to increase women’s health risks and vulnerability to environmental toxins. [ 15 16 ]…”

Section: Discussionmentioning

confidence: 99%

Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital

Sahu,

Yogeshbhai,

Oza

et al. 2024

Journal of Family Medicine and Primary Care

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“…The study results from different countries ranged from 10 to 22.5 ng/mL [ 4 , 7 , 16 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. Several studies used plasma or serum for detection, ranging from 1.18 to 5.44 ng/mL [ 14 , 35 , 36 , 37 , 38 ]. In this study, the plasma Mn concentrations in both the first and third trimesters were significantly lower than those reported by the China Nutrition and Health Survey 2010–2012 of pregnant women (2.4 ng/mL, 95% CI: first trimester 1.1–9.2 ng/mL; third trimester 1.4–7.7 ng/mL) [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China

et al. 2023

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We performed this study to clarify the dynamic changes in maternal manganese (Mn) concentration during pregnancy and its association with spontaneous preterm birth (SPB). A nested case–control study was conducted based on the Beijing Birth Cohort Study (BBCS) from 2018 to 2020. Singleton pregnancy women aged 18–44 (n = 488) were involved in the study, including 244 cases of SPB and 244 controls. All of the participants provided blood samples twice (in their first and third trimesters). Inductively coupled plasma mass spectrometry (ICP-MS) was used for the laboratory analysis, and unconditional logistic regression was used for the statistical analysis. We found that the maternal Mn levels were significantly higher in the third trimester than those in the first trimester (median: 1.23 vs. 0.81 ng/mL). The SPB risk was increased to 1.65 (95% CI: 1.04–2.62, p = 0.035) in the highest Mn level (third tertile) in the third trimester, especially in normal-weight women (OR: 2.07, 95% CI: 1.18–3.61, p = 0.011) or non-premature rupture of membrane (PROM) women (OR: 3.93, 95% CI: 2.00–7.74, p < 0.001). Moreover, a dose-dependent relationship exists between the SPB risk and maternal Mn concentration in non-PROM women (P trend < 0.001). In conclusion, dynamic monitoring of maternal Mn level during pregnancy would be helpful for SPB prevention, especially in normal-weight and non-PROM women.

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“…Dietary information over the past month was collected using a newly designed, electronic, DHA-specific, semi-quantitative FFQ, as described previously (27,28,31) . The FFQ was developed originally to capture all DHA-containing foods mentioned in China Food Composition Table (Version 2009) (32) , including marine aquatic products (seventy-five items such as mackerel, lobster and crab), freshwater aquatic products (thirty-eight items such as carp, shrimp and river crab) and mutton.…”

Section: Baseline Data and Blood Sample Collectionmentioning

confidence: 99%

Geographic variations and determinants of EPA plus DHA and EPA alone in pregnant and lactating women from China

Yin

Zhou

et al. 2021

Br J Nutr

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Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are essential for maternal and fetal health, but epidemiological data is sparse in China. We examined the trends of EPA alone and a combination of EPA plus DHA in pregnant and lactating women in three distinct geographic regions in China, and explored their potential influencing factors. A total of 1015 healthy women during mid-pregnancy, late pregnancy, or lactation were recruited from Weihai (coastland), Yueyang (lakeland), and Baotou (inland) cities of China between May and July of 2014. Maternal EPA and DHA concentrations (percentage of total fatty acids) in plasma and erythrocytes were measured by capillary gas chromatography. Adjusted EPA plus DHA concentrations in both plasma and erythrocytes significantly declined from mid-pregnancy (2.92%,6.95%), to late pregnancy (2.20%,6.42%) and lactation (2.40%,6.29%) (Ptrend<0.001); and both concentrations were highest in coastland, followed by lakeland, and lowest in inland (P<0.001). Regarding EPA alone, the concentrations were higher in women during lactation or late pregnancy and in women in coastland and inland areas. Moreover, concentrations of EPA or EPA plus DHA were higher in women with older age, higher education, higher annual family income per capita, and higher dietary intake of marine aquatic product and mutton. In lactating women, erythrocyte EPA concentration was higher in those having breastfeeding partially versus exclusively. In conclusion, maternal plasma and erythrocyte concentrations of EPA plus DHA or EPA alone differed with geographic regions, physiological periods and maternal characteristics, indicating a need of population-specific health strategies to improve fatty acids status in pregnant and lactating women.

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Patterns and Determinants of Essential and Toxic Elements in Chinese Women at Mid-Pregnancy, Late Pregnancy, and Lactation

Cited by 7 publications

References 44 publications

Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital

Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital

Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China

Geographic variations and determinants of EPA plus DHA and EPA alone in pregnant and lactating women from China

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