Pattern-Based Differential Diagnosis in Pulmonary Vasculitis Using Volumetric CT

Marten, Katharina; Schnyder, P.; Schirg, E; Prokop, Mathias; Rummeny, Ernst J.; Engelke, Christoph

doi:10.2214/ajr.184.3.01840720

Cited by 61 publications

(44 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most common radiographic and CT abnormalities, seen at presentation in up 90% of patients, consist of lung nodules and masses [6]. Airspace consolidations and patchy or less commonly diffuse ground-glass opacities are the second most common radiographic finding (20%-50% of cases) and may occur with or without associated lung nodules and masses.…”

Section: Discussionmentioning

confidence: 99%

“…Symptoms include cough, hemoptysis, dyspnea, and anemia. However, chest radiographic and CT findings are nonspecific (the alveolar infiltrates can even sometimes be unilateral), and hemoptysis may be lacking [6]. The diagnosis is usually made with bronchoscopy, by means of which serial bronchoalveolar lavage samples (from the same location) reveal an increasing red blood cell count.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diffuse Alveolar Hemorrhage: Wegener’s Granulomatosis Relapse after Inadequate Treatment

Carpagnano¹,

Lacedonia²,

Koutelou³

et al. 2012

J Clin Case Rep

View full text Add to dashboard Cite

Granulomatosis with Polyangiitis (GPA) represent the most common Antineutrophil Cytoplasmic Autoantibody (ANCA)-associated vasculitis. The treatment modalities indicated for the initial manifestations are steroids and cyclophosphamide therapy. Diffuse alveolar hemorrhage is a life-threatening though rare complication of GPA. A case of GPA with diffuse alveolar hemorrhage and hypoxemic respiratory failure is reported, as the manifestation of the disease, after inadequate drug regimen and that responded to aggressive cyclophosphamide and steroids therapy and non invasive mechanical ventilation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diffuse Alveolar Hemorrhage: Wegener’s Granulomatosis Relapse after Inadequate Treatment

Carpagnano¹,

Lacedonia²,

Koutelou³

et al. 2012

J Clin Case Rep

View full text Add to dashboard Cite

show abstract

“…Nodular and cavitary lesions can be seen in pulmonary metastases, septic emboli and lung abscesses [37]. Ground glass pattern can be a manifestation of a wide variety of pulmonary diseases including pulmonary edema, hypersensitivity pneumonitis, alveolar proteinosis, idiopathic pulmonary fibrosis and resolving pneumonia [37,51].…”

Section: Pulmonary Findings In Childhood Systemic Vasculitismentioning

confidence: 99%

Imaging of systemic vasculitis in childhood

et al. 2015

View full text Add to dashboard Cite

The term "systemic vasculitis" encompasses a diverse set of diseases linked by the presence of blood-vessel inflammation that are often associated with critical complications. These diseases are uncommon in childhood and are frequently subjected to a delayed diagnosis. Although the diagnosis and treatment may be similar for adult and childhood systemic vasculitides, the prevalence and classification vary according to the age group under investigation. For example, Kawasaki disease affects children while it is rarely encountered in adults. In 2006, the European League Against Rheumatism (EULAR) and the Pediatric Rheumatology European Society (PReS) proposed a classification system for childhood vasculitis adopting the system devised in the Chapel Hill Consensus Conference in 1993, which categorizes vasculitides according to the predominant size of the involved blood vessels into small, medium and large vessel diseases. Currently, medical imaging has a pivotal role in the diagnosis of vasculitis given recent developments in the imaging of blood vessels. For example, early diagnosis of coronary artery aneurysms, a serious complication of Kawasaki disease, is now possible by magnetic resonance imaging (MRI) of the heart and multidetector computed tomography (MDCT); positron emission tomography/CT (PET/CT) helps to assess active vascular inflammation in Takayasu arteritis. Our review offers a unique approach using the integration of the proposed classification criteria for common systemic childhood vasculitides with their most frequent imaging findings, along with differential diagnoses and an algorithm for diagnosis based on common findings. It should help radiologists and clinicians reach an early diagnosis, therefore facilitating the ultimate goal of proper management of affected children.

show abstract

“…11). 40 Approximately 15% of lesions have associated groundglass halos indicative of perilesional hemorrhage. As is typical of most vasculitides, pulmonary manifestations often have a waxing, waning, or migratory appearance with or without treatment.…”

Section: Granulomatosis With Polyangitismentioning

confidence: 99%