Pattern and Morphogenesis in Skin

Moore, George T.; Jackson, N; Isaacs, K.; Brown, George H.

doi:10.1006/jtbi.1997.0567

Cited by 46 publications

(49 citation statements)

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“…The population is a component of the fetal mesenchyme, cells whose fate is committed to a follicle lineage prior to initiation (28,29). Evidence here of Delta+ cells in ovine mesenchyme and their later appearance in dermal condensates is consistent with the existence of such a defined cell population as previously proposed (28,30).…”

Section: Discussionsupporting

confidence: 87%

Evidence that Notch and Delta expressions have a role in dermal condensate aggregation during wool follicle initiation

Xavier

Gordon-Thomson

Wynn

et al. 2013

Experimental Dermatology

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Additional Supporting Information may be found in the online version of this article:Data S1. Material and methods. Figure S1. Schematic illustration of signaling in CD 95-induced apoptosis. Abstract: Notch pathway genes have been implicated in the commitment of mesenchymal cells to a wool follicle cell fate. Notch1 and Delta1 transcripts were quantified in fetal skin of fine-woolled (Merino) and strong-woolled (Tukidale) sheep at two time points: either preceding (d56) or during (d70) the first wave of follicle initiation. DIG-labelled probes for both transcripts were localised in the epithelium, some mesenchymal cells, and in the dermal condensates of primordia. The possibility that condensates selectively incorporated Delta1-labelled mesenchymal cells is considered. The involvement of Notch1 in condensate formation was also explored in cultured fetal skin explants and whisker papilla cells using DAPT to block Notch signalling. In its presence, follicle initiation in skin explants was reduced, and the propensity for cultured papilla cells to aggregate was abolished. Results suggest that Notch1 activation is a prerequisite for mesenchymal aggregation. It is speculated that Delta interactions contribute to condensate formation, in vivo. DOI

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Section: Discussionsupporting

confidence: 87%

Evidence that Notch and Delta expressions have a role in dermal condensate aggregation during wool follicle initiation

Xavier

Gordon-Thomson

Wynn

et al. 2013

Experimental Dermatology

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“…This then leads to the formation of the feather or hair primordia, evenly spaced with interfollicular skin. Similar processes were proposed for hair / wool formation (Meinhardt and Gierer, 2000;Nagorcka and Mooney, 1985;Moore et al, 1998). It should be emphasized that the process of periodic patterning can be uncoupled from the developmental wave process discussed in the last paragraph.…”

Section: Periodic Patterningmentioning

confidence: 54%

Distinct mechanisms underlie pattern formation in the skin and skin appendages

Widelitz

Baker²,

Plikus

et al. 2006

Birth Defects Research Pt C

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SummaryPatterns form with the break of homogeneity, leading to the emergence of new structure or arrangement. There are different physiological and pathological mechanisms which lead to the formation of patterns. Here we first introduce the basics of pattern formation and their possible biological basis. We then discuss different categories of skin patterns and their potential underlying molecular mechanisms. Some patterns, such as the lines of Blaschko and naevus, are based on cell lineage and genetic mosaicism. Other patterns, such as regional specific skin appendages, can be set by distinct combinatorial molecular codes, which in turn may be set by morphogenetic gradients. There are also some patterns, such as the arrangement of hair follicles (hair whorls) and fingerprints, which involve genetics as well as stochastic epigenetic events based on physical-chemical principles. Many appendage primordia are laid out in developmental waves. In the adult, some patterns, such as those involving cycling hair follicles, may appear as traveling waves in mutant mice. Since skin appendages can renew themselves in regeneration, their size and shape can still change in the adult via regulation by hormones and the environment. Some lesion patterns are based on pathological changes involving the above processes and can be used as diagnostic criteria in medicine. Understanding the different mechanisms which lead to patterns on the skin will help us appreciate their full significance in morphogenesis and medical research. Much remains to be learned about complex pattern formation, a level between molecular biology and organism phenotypes.

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“…The basis for the control of follicle initiation, follicle density and the consequent follicle and fibre attributes of the adult animals has been proposed to be due to (a) competition between wool follicles [11], (b) a biochemical pattern-forming mechanism (reaction-diffusion (RD) theory) [21,22], and (c) competition for a limited pool of dermal pre-papilla stem cells [20]. None of the above models adequately accounts for the observed variation.…”

Section: Underlying Biology Of Fibre Production In Wool Sheepmentioning

confidence: 99%

“…However, in an elegant examination of the relationship between foetal and adult follicle characteristics, Adelson et al [1] have shown that control of follicle bulb size and fibre diameter occurs after follicle initiation. Finally, the founder cell hypothesis proposes a fixed population of pre-papilla cells, and that this population of cells acts as a limiting resource for follicle initiation [20]. Doubt has been cast over the validity of this model by the demonstration that the papilla cells divide during follicle development, and that the papilla can recruit dermal cells from the surrounding tissue [1].…”

Section: Underlying Biology Of Fibre Production In Wool Sheepmentioning

confidence: 99%

Major genes and QTL influencing wool production and quality: a review

Purvis

Franklin

2005

Genet. Sel. Evol.

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-The opportunity exists to utilise our knowledge of major genes that influence the economically important traits in wool sheep. Genes with Mendelian inheritance have been identified for many important traits in wool sheep. Of particular importance are genes influencing pigmentation, wool quality and the keratin proteins, the latter of which are important for the morphology of the wool fibre. Gene mapping studies have identified some chromosomal regions associated with variation in wool quality and production traits. The challenge now is to build on this knowledge base in a cost-effective way to deliver molecular tools that facilitate enhanced genetic improvement programs for wool sheep.gene / major gene / QTL / wool production / wool quality

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Pattern and Morphogenesis in Skin

Cited by 46 publications

References 0 publications

Evidence that Notch and Delta expressions have a role in dermal condensate aggregation during wool follicle initiation

Evidence that Notch and Delta expressions have a role in dermal condensate aggregation during wool follicle initiation

Distinct mechanisms underlie pattern formation in the skin and skin appendages

Major genes and QTL influencing wool production and quality: a review

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