Patología de los tumores neuroblásticos: evaluación pronóstica. Experiencia del centro español de referencia de la SEOP para estudios biopatológicos del neuroblastoma (1992-2005)

Role of Genetic Polymorphisms -238 G>A and -308 G>A, and Serum TNF-α Levels in a Cohort of Mexican Pediatric Neuroblastoma Patients: Preliminary Study

“…The staging of Neuroblastoma tumors in this study was performed based on clinical, radiographic, and surgical evaluation, according to the criteria of the International Neuroblastoma Staging System (INSS) and the International Neuroblastoma Risk Group (INRG) [ 64 , 65 ]. The degree of differentiation of neuroblastic tumors was determined based on histopathological criteria following the classification parameters of the International Neuroblastoma Pathology Classification (INCP), for which histopathological and immunohistochemical studies were performed on the tumor material, such as the detection of the NB84 marker, morphometric evaluation to study ploidy, and molecular analysis to determine MYCN amplification [ 66 , 67 ]. The histology according to the Shimada system, was based on the amount of Schwannian stroma, the degree of differentiation, the mitosis–karyorrhexis index (MKI), and age at diagnosis, classifying the tumors into two groups of favorable and unfavorable histological prognosis [ 9 , 64 ].…”

Role of Genetic Polymorphisms -238 G>A and -308 G>A, and Serum TNF-α Levels in a Cohort of Mexican Pediatric Neuroblastoma Patients: Preliminary Study

“…The staging of Neuroblastoma tumors in this study was performed based on clinical, radiographic, and surgical evaluation, according to the criteria of the International Neuroblastoma Staging System (INSS) and the International Neuroblastoma Risk Group (INRG) [ 64 , 65 ]. The degree of differentiation of neuroblastic tumors was determined based on histopathological criteria following the classification parameters of the International Neuroblastoma Pathology Classification (INCP), for which histopathological and immunohistochemical studies were performed on the tumor material, such as the detection of the NB84 marker, morphometric evaluation to study ploidy, and molecular analysis to determine MYCN amplification [ 66 , 67 ]. The histology according to the Shimada system, was based on the amount of Schwannian stroma, the degree of differentiation, the mitosis–karyorrhexis index (MKI), and age at diagnosis, classifying the tumors into two groups of favorable and unfavorable histological prognosis [ 9 , 64 ].…”

Role of Genetic Polymorphisms -238 G>A and -308 G>A, and Serum TNF-α Levels in a Cohort of Mexican Pediatric Neuroblastoma Patients: Preliminary Study

“…The staging of Neuroblastoma tumors in this study was performed based on clinical, radiographic, and surgical evaluation, according to the criteria of the International Neuroblastoma Staging System (INSS) and the International Neuroblastoma Risk Group (INRG) [ 64 , 65 ]. The degree of differentiation of neuroblastic tumors was determined based on histopathological criteria following the classification parameters of the International Neuroblastoma Pathology Classification (INCP), for which histopathological and immunohistochemical studies were performed on the tumor material, such as the detection of the NB84 marker, morphometric evaluation to study ploidy, and molecular analysis to determine MYCN amplification [ 66 , 67 ]. The histology according to the Shimada system, was based on the amount of Schwannian stroma, the degree of differentiation, the mitosis–karyorrhexis index (MKI), and age at diagnosis, classifying the tumors into two groups of favorable and unfavorable histological prognosis [ 9 , 64 ].…”

Role of Genetic Polymorphisms -238 G>A and -308 G>A, and Serum TNF-α Levels in a Cohort of Mexican Pediatric Neuroblastoma Patients: Preliminary Study

“…The staging of Neuroblastoma tumors in this study was performed based on clinical, radiographic, and surgical evaluation, according to the criteria of the International Neuroblastoma Staging System (INSS) and the International Neuroblastoma Risk Group (INRG) [ 64 , 65 ]. The degree of differentiation of neuroblastic tumors was determined based on histopathological criteria following the classification parameters of the International Neuroblastoma Pathology Classification (INCP), for which histopathological and immunohistochemical studies were performed on the tumor material, such as the detection of the NB84 marker, morphometric evaluation to study ploidy, and molecular analysis to determine MYCN amplification [ 66 , 67 ]. The histology according to the Shimada system, was based on the amount of Schwannian stroma, the degree of differentiation, the mitosis–karyorrhexis index (MKI), and age at diagnosis, classifying the tumors into two groups of favorable and unfavorable histological prognosis [ 9 , 64 ].…”