Patients with psoriasis have elevated levels of serum eosinophil cationic protein and increased numbers of EG2 positive eosinophils in the duodenal stroma

Abstract

The occurrence of EG2-positive (EG2+) eosinophils and IgE in biopsy specimens of duodenal mucosa and skin from 39 psoriasis patients was studied, with emphasis on the relation to serum eosinophil cationic protein (ECP), serum IgE and the presence or absence of serum IgA and IgG antigliadin antibodies. Psoriasis patients had significantly elevated serum levels of ECP even after exclusion of five of 37 sera which were Phadiatop positive. The elevated serum ECP was not associated with the presence of IgA or IgG antibodies to gliadin. After exclusion of Phadiatop positive sera the serum IgE values did not differ from those of a group of healthy blood donors. Patients with psoriasis had a pronounced increase of EG2+ cells in their duodenal stroma. Patients without antibodies to gliadin tended to have even more EG2+ cells than those with such antibodies and those with increased duodenal intraepithelial lymphocytes. IgE+ cells were present in most duodenal specimens, and in some specimens there were > 100 IgE+ cells/section. The number of EG2+ cells was increased in lesional skin and, in some patients, also in non-involved skin, but there was a more pronounced increase in EG2 reactivity in the duodenal than in the skin specimens. IgE reactivity was increased both in non-involved and involved skin and was significantly related to the number of IgE-positive cells in the duodenal stroma. The results of this study indicate that the gastrointestinal tract and the eosinophil granulocyte might be involved in psoriasis in a hitherto unknown way.

Assessments of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in Korean patients with psoriasis vulgaris and psoriatic arthritis

“…Interestingly, eosinophils were increased in psoriasis patients compared with controls. Although it may be due to selection bias, some reports had addressed elevation of eosinophil cationic protein in the serum of psoriasis patients and pruritus in psoriasis and found it to be associated with eosinophil activation . Hb level was significantly decreased in PsA patients compared with both psoriasis patients and controls.…”

Eosinophil-Count-Derived Inflammatory Markers and Psoriasis Severity: Exploring the Link

“…Moreover, psoriatic patients present with elevated levels of eosinophil cationic protein (ECP), both in the serum and affected skin [14,43]. Elevated serum ECP is linked to psoriasis, irrespective of disease severity; however, values were observed in patients presenting with moderate and severe psoriasis.…”

“…Elevated serum ECP is linked to psoriasis, irrespective of disease severity; however, values were observed in patients presenting with moderate and severe psoriasis. Moreover, Michaelsson et al [43] found that patients with psoriasis presented with low EG2 positive (EG2+) activated eosinophils in the skin and higher levels of EG2+ activated eosinophils in the duodenum compared to those with irritable bowel syndrome, even in association with negative gliadin antibodies. These findings indicate that it is highly unlikely in such cases for elevated serum ECP to be due to eosinophil activation in the skin and thus suggest that elevated EG2+ activated eosinophils in the duodenum may properly reflect the inflammatory activity of psoriatic skin.…”