2013
DOI: 10.1136/postgradmedj-2012-131185
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Abstract: Purpose of the studyHepatitis C virus (HCV) is associated with neuropsychiatric complaints. Previous studies have associated cognitive alterations with HCV infection but have often included confounding factors in their samples. This study compares the cognitive performance between patients with HCV infection (HCV patients) and a control group while excluding other factors that may cause cognitive impairment.Study designThis cross-sectional study was conducted from March 2010 through June 2011. HCV infected pat… Show more

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Cited by 27 publications
(27 citation statements)
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“…In an attempt to eliminate confounding factors in the cognitive assessment of patients with HCV, the authors of the present review have used a rigorous selection criterion and applied an extended cognitive battery in a previous study. Exclusion of depression and advanced stages of liver fibrosis (F3 and F4 of the METAVIR classification) resulted in a group of HCV carriers with cognitive performance similar to age and educational level-paired control group [25]. However, the use of a low cut-off point in the Beck Depression Inventory (BDI) in this study, excluding cases whose symptoms only suggested mild forms of depression, may have resulted in selection bias and removed from the sample a representative population of patients with HCV.…”
Section: Evidence Of Cognitive Dysfunction In Patients With Hcvmentioning
confidence: 99%
“…In an attempt to eliminate confounding factors in the cognitive assessment of patients with HCV, the authors of the present review have used a rigorous selection criterion and applied an extended cognitive battery in a previous study. Exclusion of depression and advanced stages of liver fibrosis (F3 and F4 of the METAVIR classification) resulted in a group of HCV carriers with cognitive performance similar to age and educational level-paired control group [25]. However, the use of a low cut-off point in the Beck Depression Inventory (BDI) in this study, excluding cases whose symptoms only suggested mild forms of depression, may have resulted in selection bias and removed from the sample a representative population of patients with HCV.…”
Section: Evidence Of Cognitive Dysfunction In Patients With Hcvmentioning
confidence: 99%
“…In addition, several studies have reported down regulated mitochondrial oxidative phosphorylation genes and reduced expression of specific ribosomal protein genes in post-mortem brain tissue from HCV+ patients (Adair et al, 2005). HCV-associated cognitive dysfunction is not significantly correlated with impaired liver function tests and the impact of antiviral medications for HCV infection is uncertain (Abrantes et al, 2013; Fontana et al, 2005; McAndrews et al, 2005; Weissenborn et al, 2004). …”
Section: Discussionmentioning
confidence: 99%
“…It is also a leading cause of cirrhosis and liver cancer (Alter et al, 1999; Shepard, Finelli, & Alter, 2005) (Armstrong, Alter, McQuillan, & Margolis, 2000). HCV infection can be associated with cognitive dysfunction, but the association itself and the basis for the association are controversial (Abrantes, Torres, & Mello, 2013; Gaeta, Di Paolo, Fasanaro, & Loguercio, 2013; Perry, Hilsabeck, & Hassanein, 2008; Senzolo et al, 2011). Though initially attributed to hepatic encephalopathy, cognitive dysfunction has also been noted prior to onset of liver dysfunction (Forton et al, 2002) .…”
Section: Introductionmentioning
confidence: 99%
“…There was no significant difference between treated (38%) and untreated patients (36.2 %) regarding cognitive impairment at baseline (χ² = 0.4, p = 0.8). Cognitive performance of the treated group was significantly impaired after interferon as reflected in the total MOCA score and in cognitive domains of visuo-constructional skills, sustained attention, concentration, working memory, language and short term memory as shown in Table ( 1). There was no significant changes in any of the cognitive domains or the total MOCA score (24.5± 2.2 vs.24.3± 2.5, t= 0.5; p = 0.6) in the untreated group after 12-week of observation.…”
Section: Prevalence Of Cognitive Impairmentmentioning
confidence: 99%