Patients with bisphosphonates‐associated osteonecrosis of the jaw have reduced circulating endothelial cells

Allegra, Alessandro; Oteri, Giacomo; Nastro, Enrico; Alonci, Andrea; Bellomo, Giacomo; Fabro, Vittorio Del; Quartarone, Eugenia; Alati, Caterina; Ponte, Francesco Saverio De; Cicciù, D; Musolino, Caterina

doi:10.1002/hon.819

Cited by 61 publications

(32 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is an unexpected finding as in previous studies we demonstrated the possibility that BPs could have a suppressive effect on angiogenesis (4,38). However, BPs could exert a different action on bone and mucosal tissue.…”

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw

Siniscalchi

Cutroneo²,

Catalfamo³

et al. 2010

Oncol Rep

View full text Add to dashboard Cite

Abstract. Osteonecrosis of the jaw (ONJ) is an adverse outcome associated to bisphosphonate treatment. However, it is not known whether the ONJ lesion originates in the bone, or whether it may initiate in the oral mucosa. The aim of our study was to evaluate the pattern of basal lamina of oral mucosa after bisphosphonate administration and to analyze the structural damage of the mucosa in ONJ patients, and in subjects treated with bisphosphonates without osteonecrosis. By immunohistochemistry, we evaluated changes in basement membrane by expression of signalling proteins, laminin, and type IV collagen. All tested proteins were almost absent in basal lamina and mucosa of subjects treated with bisphosphonates without osteonecrosis, whereas in mucosa of patients with ONJ, they showed a clearly detectable pattern of the same proteins, specifically in basal lamina, but less in comparison to control samples. Moreover, in pathological mucosa, the clearly detectable staining pattern for VEGF indicated a massive neoangiogenesis. Bisphosphonates induce changes in expression of proteins also in oral mucosa. The increase of these proteins in basal lamina, and the neoangiogenesis, concomitant with formation of the lesion, could indicate a compensative behaviour in the remodelling of the gingival mucosa in order to restore the epithelial architecture.

show abstract

Section: Discussionsupporting

confidence: 69%

“…Several theories have been proposed regarding the pathoetiology of ONJ, e.g. that necrosis is related to an over-suppression of bone turnover by BPs (2) or that BPs decrease angiogenesis (3,4).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw

Siniscalchi

Cutroneo²,

Catalfamo³

et al. 2010

Oncol Rep

View full text Add to dashboard Cite

show abstract

“…Our data are different from results presented in a previous work [14] which demonstrated that there is an increase in CECs in patients with myeloma. This discrepancy could be due to the different characteristics of the patients studied.…”

Section: Discussioncontrasting

confidence: 57%

“…In a previous work using flow-cytometric analysis, we demonstrated a decrease in circulating endothelial progenitor cells (EPCs) in patients with BP ONJ compared to control subjects [14]. …”

Section: Introductionmentioning

confidence: 99%

Bisphosphonates Induce Apoptosis of Circulating Endothelial Cells in Multiple Myeloma Patients and in Subjects with Bisphosphonate-Induced Osteonecrosis of the Jaws

et al. 2010

View full text Add to dashboard Cite

Bisphosphonates (BPs) are the current standard of care for bone lesions in patients with multiple myeloma (MM) but they are associated with a number of side effects such as osteonecrosis of the jaw. The exact mechanisms of osteonecrosis are not elucidated, and its physiopathology is based on several hypotheses such as a decrease in bone remodeling or an inhibitory effect on angiogenesis. The aim of our study was to investigate the mechanism involved in the pathogenesis of osteonecrosis. We examined the apoptosis of circulating endothelial progenitor cells in MM subjects before and after BP treatment and in osteonecrosis patients using a flow-cytometric analysis. Our data showed an increase in endothelial cell apoptosis in MM patients after BP administration and in osteonecrosis subjects. Our study seems in agreement with the hypothesis that BPs can inhibit angiogenesis interfering with endothelial cell proliferation and survival, leading to loss of blood vessels and avascular necrosis.

show abstract

“…The antiangiogenic activity of NBPs has been suggested as one of the main determinants of ONJ onset. [42][43][44] A recent review reported a wideranging ONJ incidence from 0% to 27.5%, relevant to individuals exposed to intravenous NBP, with a mean incidence of 7%. 45 Table 1 Continued This retrospective exploratory study was aimed at describing the occurrence and the nature of ONJ associated with the use of NBP and targeted agents in RCC patients.…”

Section: Discussionmentioning

confidence: 97%

Osteonecrosis of the Jaw in Patients With Metastatic Renal Cell Cancer Treated With Bisphosphonates and Targeted Agents: Results of an Italian Multicenter Study and Review of the Literature

Fusco

Porta

Saia

et al. 2015

Clinical Genitourinary Cancer

View full text Add to dashboard Cite

Patients with bisphosphonates‐associated osteonecrosis of the jaw have reduced circulating endothelial cells

Cited by 61 publications

References 25 publications

Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw

Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw

Bisphosphonates Induce Apoptosis of Circulating Endothelial Cells in Multiple Myeloma Patients and in Subjects with Bisphosphonate-Induced Osteonecrosis of the Jaws

Osteonecrosis of the Jaw in Patients With Metastatic Renal Cell Cancer Treated With Bisphosphonates and Targeted Agents: Results of an Italian Multicenter Study and Review of the Literature

Contact Info

Product

Resources

About