Patients with atypical hyperplasia of the endometrium should be treated in oncological centers

Accuracy of Frozen Sections for Intraoperative Diagnosis of Complex Atypical Endometrial Hyperplasia

“…The risk of concomitant endometrial carcinoma has been reported to be 20-59% in CAEH (Janicek & Rosenheim, 1994;Trimble et al, 2006;Antonsen et al, 2012). FS identifies the patients who are at high risk for extrauterine spread and often surgical management of patients with preoperative diagnosis of endometrial CAEH is influenced by intraoperative FS.…”

“…The rate of progression to endometrial carcinoma has been estimated to be 0-3% in patients without atypia, 0-8% in patients with simple atypical hyperplasia, and 9-29% in patients with complex atypical endometrial hyperplasia (CAEH) (Kurman et al, 1985;Tabata et al, 2001). The risk of concomitant endometrial carcinoma has been reported to be 20-59% in CAEH (Lambert et al, 1994;Kimura et al, 2003;Valenzuela et al, 2003;Antonsen et al, 2012;Morotti et al, 2012). In addition to, the distinction between atypical endometrial hyperplasia and well differentiated adenocarcinoma of the endometrium is one of the more difficult differential diagnoses in gynecologic pathology (Mills & Longacre, 2011 deep myometrial invasion, and cervical extension of the tumor.…”

Comparison of endometrial biopsy and postoperative hysterectomy specimen findings in patients with atypical endometrial hyperplasia and endometrial cancer

“…The diagnosis is based on the histological examination of endometrial samples. However, discrepancy between histological findings before and after surgery is well-documented [8][9][10][11][12]. The clinical implications are serious considering the potential effects on surgical staging www.…”

“…journals.viamedica.pl/ginekologia_polska decisions and disease outcomes. With a preoperative diagnosis of atypical hyperplasia of the endometrium, the scope of planned surgical treatment may be inadequate when endometrial cancer is ultimately diagnosed at hysterectomy [8][9][10] and that is why accuracy of preoperative histology is very important. In cases of a malignant tumour of the uterine corpus, pathological findings in the hysterectomy specimens usually confirm the preoperative diagnosis.…”

Which Endometrial Pathologies Need Intraoperative Frozen Sections?

“…Morotti et al (2012) reported that frozen section effeciently identified the cases that diagnosed with AEH on endometrial biopsy (Morotti et al, 2012). Antonsen et al founded that 59% of women diagnosed preoperatively with AEH had cancer, and one in three of these patients had a high-risk cancer requiring full staging procedure (Antonsen et al, 2012). Frozen section analysis of hysterectomy specimens in patients with atypical endometrial hyperplasia was found to be necessary to determine the presence of cancer and the need for surgical staging in a different study (Gundem et al, 2003).…”