Patients with a fast progression profile in geographic atrophy have increased CD200 expression on circulating monocytes

Nielsen, Marie Krogh; Subhi, Yousif; Molbech, Christopher Rue; Falk, Mads Krüger; Singh, Amardeep; Nissen, Mogens Holst; Sørensen, Torben Lykke

doi:10.1111/ceo.13362

Cited by 14 publications

(13 citation statements)

References 54 publications

(110 reference statements)

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“…40 This is of particular interest, as inappropriate microglia activation is another key feature in GA pathogenesis. 41,42 Several limitations should be kept in mind when interpreting these results. The observational nature of this study merely provides us with associations between events, such as CCR5 expression and GA progression.…”

Section: Discussionmentioning

confidence: 99%

Chemokine Profile and the Alterations in CCR5-CCL5 Axis in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Nielsen

Subhi

Molbech

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

Chemokine Profile and the Alterations in CCR5-CCL5 Axis in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Nielsen

Subhi

Molbech

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…,b, ,b; Krogh Nielsen et al. ). Some of these studies have explored the possible role of circulating neutrophils and lymphocytes, and their ratio.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio in age‐related macular degeneration: a systematic review and meta‐analysis

Niazi

Nielsen

Sørensen

et al. 2019

Acta Ophthalmologica

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Age-related macular degeneration (AMD) is aetiologically linked to immunological ageing and dysfunction. One aspect of this is the altered neutrophil-tolymphocyte ratio (NLR), which in other domains have been associated with inflammation and angiogenesis, and therefore investigated in patients with AMD in several papers. In this systematic review and meta-analysis, we summarize findings in patients with AMD in relation to NLR, both qualitatively and quantitatively. We searched PubMed/MEDLINE, EMBASE, Web of Science, and the Cochrane Central and identified six studies from where we extracted data on 1178 individuals (777 patients with AMD and 401 healthy controls). Patients with AMD had a higher NLR (weighted mean difference: 0.37, CI 95% 0.08 to 0.66, p = 0.013) when compared to healthy controls. In subgroup analyses, we did not find a significant difference between patients with dry AMD and healthy controls (weighted mean difference: 0.34, CI 95% À0.03 to 0.69, p = 0.068), but did find a strong significant difference between patients with neovascular AMD and healthy controls (weighted mean difference: 0.54, CI 95% 0.23 to 0.86, p = 0.00068). Hence, we find that the association between AMD and elevated NLR may have stronger relevance to the neovascular subtype of AMD. However, the clinical value of measuring the NLR remains unclear.

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“…CD200 is another surface glycoprotein expressed by many cell types including monocytes that is thought to attenuate inflammation, via activation of its receptor CD200R. Notably, the expression of CD200 on monocytes in those with rapidly progressing geographic atrophy was shown to increase in comparison to those with slowly progressing geographic atrophy or healthy age matched controls …”

Section: Peripheral Blood Monocytes and Age Related Macular Degenerationmentioning

confidence: 99%

“…Notably, the expression of CD200 on monocytes in those with rapidly progressing geographic atrophy was shown to increase in comparison to those with slowly progressing geographic atrophy or healthy age matched controls. 57 In order to understand whether specific leucocyte types are modified during AMD, studies in cell specific populations have been undertaken. Peripheral blood monocytes are traditionally identified by their surface markers, CD14 and CD16: classical monocytes are CD14+ and show low levels of CD16, whereas non-classical monocytes have high surface expression of CD16 and low levels of CD14.…”

Section: Peripheral Blood Monocytes and Age Related Macular Degenerationmentioning

confidence: 99%

Contribution of microglia and monocytes to the development and progression of age related macular degeneration

Fletcher

2020

Ophthalmic Physiologic Optic

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Purpose Age related macular degeneration (AMD) is the leading cause of irreversible vision loss in industrialised nations. Based on genetics, as well as proteome analysis of drusen, the role the innate immune system in the development and/or progression of the disease is well established. Mononuclear phagocytes, such as microglia and monocytes, play critical roles in innate immunity. Here, the role of retinal microglia in mediating normal retinal function, and how these cells change with age is discussed, so as to understand their role in the development and progression of AMD. Recent findings It is now known that microglia dynamically survey the neural environment, responding rapidly to even the most subtle neural injury. The dynamic and phagocytic roles of microglia can change with age contributing to alteration in the response of these cells to damage with age. Accumulation of innate immune cells in the subretinal space is a hallmark feature of the development of AMD, reflecting either an increase in migration of monocytes into the retina, or a failure of immune cell elimination from the retina. Furthermore, changes in phagocytic ability of immune cells could contribute to the accumulation of drusen deposits in the posterior eye. Summary An overview of how retinal microglia maintain retinal homeostasis under normal conditions is provided, and then how they contribute to each stage of AMD. In addition, circulating monocytes are altered in those with AMD, contributing to the overall inflammatory state. Understanding the role of cells of the innate immune system in AMD may uncover novel therapeutic targets with which to reduce either the development or progression of disease.

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Patients with a fast progression profile in geographic atrophy have increased CD200 expression on circulating monocytes

Abstract: Our data reveals that abnormal monocytic CD200 expression is present in GA, and in particular among those identified as fast progressors.

Cited by 14 publications

References 54 publications

Chemokine Profile and the Alterations in CCR5-CCL5 Axis in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Chemokine Profile and the Alterations in CCR5-CCL5 Axis in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Neutrophil‐to‐lymphocyte ratio in age‐related macular degeneration: a systematic review and meta‐analysis

Contribution of microglia and monocytes to the development and progression of age related macular degeneration

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