Oxygen is an essential component of wound healing. The discovery of its critical role in maintaining life and healing properties dates back to the late 1700's. With the invention of hyperbaric oxygen chamber in 1879 research into the medicinal utilization of oxygen began and continues today. More recently, hyperbaric oxygen therapy has been studied and implemented for a variety of functions including wound healing, but recently its effectiveness has been questioned. Due to some of its more adverse side effects, the development of a more localized therapy option transcutaneous trans-cutaneous oxygenation has found its niche in the role of wound healing. Compiling the research and studies of the use of transcutaneous trans-cutaneous oxygenation in the literature, a statistical analysis was utilized to evaluate its efficacy in wound healing.