Patient-defined goals and preferences among older adults with cancer starting chemotherapy (CT).

Celis, Enrique Soto Perez De; Li, Daneng; Sun, Can‐Lan; Kim, Heeyoung; Twardowski, Przemyslaw; Fakih, Marwan; Chung, Vincent; Cristea, Mihaela; Lim, Dean; Yuan, Yuan; Dale, William; Chien, Leana Cabrera; Charles, Kemeberly; Tan, Heidi; Roberts, Elsa; Moreno, Jeanine; Rivera, Daisy; Katheria, Vani; Hurria, Arti

doi:10.1200/jco.2018.36.15_suppl.10009

Cited by 55 publications

(37 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite these statistics, clinical trials carry a dearth of older patients, and this results in limited data for shared decision making for cancer treatment . Oncologists are tasked with treating older patients while balancing patient preferences and quality of life …”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7] Oncologists are tasked with treating older patients while balancing patient preferences and quality of life. 8,9 A geriatric assessment (GA) including a nutritional evaluation is recommended for evaluating older adults with cancer before the initiation of cancer therapy because nutritional concerns are commonly identified among older patients. [10][11][12][13][14][15] Undernutrition, which is defined as insufficient intake of nutrients to meet the patient's energy needs, is commonly seen among patients with cancer and has been shown to be a risk factor for morbidity, mortality, and treatment intolerance.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Associations between nutritional factors and chemotherapy toxicity in older adults with solid tumors

Dotan

Tew

Mohile

et al. 2020

Cancer

Self Cite

View full text Add to dashboard Cite

Background Nutritional status can directly affect morbidity and mortality in older adults with cancer. This study evaluated the association between pretreatment body mass index (BMI), albumin level, and unintentional weight loss (UWL) in the prior 6 months and chemotherapy toxicity among older adults with solid tumors. Methods This was a secondary analysis of a prospective, multicenter study involving chemotherapy‐treated patients 65 years old or older. Geriatric assessment, BMI, albumin level, and UWL data were collected before treatment. Multivariable logistic regression models evaluated the associations between nutritional factors and the risk of grade 3 or higher (grade 3+) chemotherapy toxicity. Results Seven hundred fifty patients with a median age of 72 years (range, 65‐94 years) and mostly stage IV disease were enrolled. The median pretreatment BMI and albumin values were 26 kg/m2 (range, 15.1‐52.1 kg/m2) and 3.9 mg/dL (range, 1.0‐5.0 mg/dL), respectively. Nearly 50% of the patients reported UWL, with 17.6% reporting >10% UWL. Multivariable analysis revealed no association between >10% UWL and a risk for grade 3+ chemotherapy toxicity (adjusted odds ratio [AOR], 0.87; P = .58). Multivariable analysis showed a trend toward an association between a BMI ≥ 30 kg/m2 and a decreased risk of grade 3+ chemotherapy toxicity (AOR, 0.65; P = .06), whereas a low albumin level (≤3.6 mg/dL) was associated with a higher risk of grade 3+ chemotherapy toxicity (AOR, 1.50; P = .03). An analysis of the joint effect of BMI and albumin demonstrated the lowest risk of grade 3+ chemotherapy toxicity among patients with high BMIs (≥30 kg/m2) and normal albumin levels (AOR, 0.41; P = .008). Conclusions Among older adults with solid tumors, higher BMIs and normal albumin levels are associated with a lower risk of grade 3+ chemotherapy toxicity. Additional research is warranted to define the clinical significance of nutritional markers and to inform future interventions.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations between nutritional factors and chemotherapy toxicity in older adults with solid tumors

Dotan

Tew

Mohile

et al. 2020

Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…Just as incentives differ, outcomes of interest and measures of high‐value care for clinicians differ from the perceptions of payers and/or patients. For example, although oncology care generally focuses on survival, patients value physical and cognitive function and the ability to live independently, with as many as 50% of patients rating these factors as more important than survival . By collaborating (oncology, health services research, and cancer rehabilitation researchers), multiple measures of value metrics (ie, patient, clinician, and administrator) all could be considered and evaluated.…”

Section: Introductionmentioning

confidence: 99%

A health services research agenda to fully integrate cancer rehabilitation into oncology care

Pergolotti

Alfano

Cernich

et al. 2019

Cancer

View full text Add to dashboard Cite

Adults with cancer are at risk of restricted functioning in work, usual activities, life roles, and quality of life both during and after cancer treatment. Herein, the authors discuss unique opportunities to examine how cancer rehabilitation, delivered as part of cancer and survivorship care, might help to achieve the quadruple aim of better patient health, better patient experience, and lower cost for patients who receive services, as well as improving the work life of clinicians and staff.

show abstract

“…This issue further advances our understanding of factors associated with treatment and outcomes, including in older adults with colorectal cancer and multiple myeloma, in transplant clinics, and in a geriatric oncology clinic in Mexico . Maintenance of functional independence and cognition are outcomes that are prioritized by older adults with cancer, which remain poorly characterized in clinical trials . Several articles in this issue examine these outcomes in older adults with cancer, including characterization of functional resilience among older women who received chemotherapy .…”

mentioning

confidence: 99%

“…[15][16][17][18] Maintenance of functional independence and cognition are outcomes that are prioritized by older adults with cancer, which remain poorly characterized in clinical trials. 19 Several articles in this issue examine these outcomes in older adults with cancer, including characterization of functional resilience among older women who received chemotherapy. [20][21][22] Two articles demonstrate the importance of attention to the quality of life of caregivers of older adults with cancer.…”

mentioning

confidence: 99%

Geriatric Oncology: Getting Even Better with Age

Klepin

Wildes

2019

J American Geriatrics Society

View full text Add to dashboard Cite

Patient-defined goals and preferences among older adults with cancer starting chemotherapy (CT).

Cited by 55 publications

References 0 publications

Associations between nutritional factors and chemotherapy toxicity in older adults with solid tumors

Associations between nutritional factors and chemotherapy toxicity in older adults with solid tumors

A health services research agenda to fully integrate cancer rehabilitation into oncology care

Geriatric Oncology: Getting Even Better with Age

Contact Info

Product

Resources

About