2014
DOI: 10.18632/aging.100711
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Abstract: Age-related macular degeneration (AMD) is a major cause of blindness in older people and is caused by loss of the central region of the retinal pigment epithelium (RPE). Conventional methods of gene expression analysis have yielded important insights into AMD pathogenesis, but the precise molecular pathway alterations are still poorly understood. Therefore we developed a new software program, “AMD Medicine”, and discovered differential pathway activation profiles in samples of human RPE/choroid from AMD patien… Show more

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Cited by 40 publications
(39 citation statements)
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References 55 publications
(66 reference statements)
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“…2530 In contrast with other pathway analysis tools, which implement basic pathway enrichment analysis, OncoFinder performs quantitative estimation of signaling pathway activation strength. It preserves biological function and allows for dimensionality reduction at the same time.…”
Section: Resultsmentioning
confidence: 99%
“…2530 In contrast with other pathway analysis tools, which implement basic pathway enrichment analysis, OncoFinder performs quantitative estimation of signaling pathway activation strength. It preserves biological function and allows for dimensionality reduction at the same time.…”
Section: Resultsmentioning
confidence: 99%
“…This finding is consistent with several previous studies showing that neither pathway is critical in photoreceptor cell rescue following stress both in vivo and in vitro (O'Driscoll et al ., , ; Bürgi et al ., ). The possibility of the involvement of PI3K and ERK1/2 in photoreceptor cell rescue following other cell stressors, however, cannot be ruled out (Forkwa et al ., ; Makarev et al ., ).…”
Section: Discussionmentioning
confidence: 97%
“…We observed here that the trophic influence of choroidal macrophages extended also to the maintenance of RPE structure and function. With macrophage depletion, the nature of RPE changes induced has a notable resemblance to structural and functional alterations seen with aging and AMD in the RPE layer, including increased cellular disorganization and decreased cell density in the RPE monolayer (54,55), increased numbers of multinucleated cells (56), and increased RPE dedifferentiation (57). Previous studies have connected microglia/macrophage activation with RPE alterations, but these had been in pathological situations in which increased production of inflammatory mediators exerts changes on RPE cells (58)(59)(60).…”
Section: Discussionmentioning
confidence: 99%