Pathophysiological role of ion channels and transporters in gastrointestinal mucosal diseases

Deng, Zilin; Zhao, Yingying; Ma, Zhiyuan; Zhang, Minglin; Wang, Hu; Yi, Zhiqiang; Tuo, Biguang; Li, Taolang; Liu, Xuemei

doi:10.1007/s00018-021-04011-5

Cited by 14 publications

(8 citation statements)

References 205 publications

(239 reference statements)

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“…Studies have rarely considered the balance between regulating apoptotic and anti-apoptotic processes. Ion channels are very important barriers to communication between cells and the external environment [ 131 ]. The targeted regulation or competitive binding of ion channels is an important approach to regulating cellular processes [ 132 ].…”

Section: Discussionmentioning

confidence: 99%

Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

Zhang,

Chen,

Zhan

et al. 2023

Cell Death Discov.

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Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca2+ ions via ASIC1a activation may occur in the acidified microenvironment of blood or local tissues. ASIC1a-mediated Ca2+‑induced apoptosis has been implicated in numerous pathologies, including neurological disorders, cancer, and rheumatoid arthritis. This review summarizes the role of ASIC1a in the modulation of apoptosis via various signaling pathways across different disease states to provide insights for future studies on the underlying mechanisms and development of therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

Zhang,

Chen,

Zhan

et al. 2023

Cell Death Discov.

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“…The chronic inflammation present in some gastrointestinal diseases, such as IBD, may contribute to increased oxidative stress in the gut. OS can lead to dysregulation of ICs in the gastrointestinal tract, by altering electrolyte transport, as well as increasing the secretion of mucus and water, and reducing absorption of nutrients, which contribute to the development of inflammation and tissue damage [95]. There are several types of ion channels involved in gastrointestinal pathologies, including chloride, calcium, potassium, and sodium channels.…”

Section: Ion Channels Involved In Oxidative Stress-related Gi Diseasesmentioning

confidence: 99%

The Ion Channels Involved in Oxidative Stress-Related Gastrointestinal Diseases

Miranda,

Vestuto,

Moltedo

et al. 2023

Oxygen

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The pathogenesis of various gastrointestinal (GI) disorders, including gastritis, ulcers, inflammatory bowel disease (IBD) and cancer, can be linked to oxidative stress. It is known that reactive species carry out a crucial role in the genesis and progression of these pathologies; however, the contribution of ionic channels in their development is still under discussion. The function of ion channels in the gastrointestinal tract influences a variety of cellular processes. Acid-base balance, mucus layer, microbiota and mucosal blood flow are only some of the essential features for maintaining the mucosal integrity of the cellular barrier in the intestine, allowing for the preservation of proper permeability and ensuring tissue homeostasis. As the functional modulation of several ion channels is altered during oxidative stress conditions associated with gastrointestinal inflammation, this review focuses on contributing new insight into the roles of and the relationship between ion channels and oxidative stress in GI diseases. The association between ion channels and oxidative stress conditions could be used in diagnostics and the development of new pharmacological treatments for major gastrointestinal diseases.

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“…Compared to the receptor pathways of acid secretion, studies have determined that TCMs are more effective in enabling antisecretory therapy. This therapy involves targeting the ion channels or transporters in parietal cells, which is the main strategy for treating GMI and preventing its complications ( Sverdén, et al, 2019 ; Deng, et al, 2021 ; Maev et al, 2022 ). H + /K + -ATPase is the dominant rate-limiting factor in the final step of parietal cells secreting hydrochloric acid ( Matsukawa, et al, 2018 ).…”

Section: Repairs Of the Lamina Propria Barriermentioning

confidence: 99%

Pharmacological targeting of gastric mucosal barrier with traditional Chinese medications for repairing gastric mucosal injury

Jia,

He,

et al. 2023

Front. Pharmacol.

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Introduction: The gastric mucosa (GM) is the first barrier and vital interface in the stomach that protects the host from hydrochloric acid in gastric juice and defends against exogenous insults to gastric tissues. The use of traditional Chinese medications (TCMs) for the treatment of gastric mucosal injury (GMI) has long-standing history and a good curative effect. Whereas there are poor overall reports on the intrinsic mechanisms of these TCM preparations that pharmacology uses to protect body from GMI, which is crucial to treating this disease. These existing reviews have deficiencies that limit the clinical application and development of both customary prescriptions and new drugs.Methods: Further basic and translational studies must be done to elucidate the intrinsic mechanisms of influence of these TCM preparations. Moreover, well-designed and well-conducted experiences and clinical trials are necessary to ascertain the efficacy and mechanisms of these agents. Therefore, this paper presents a focused overview of currently published literature to assess how TCMs action that facilitates the cures for GMI. It offers a whole train of current state of pharmacological evidence, identifies the pharmacological mechanisms of TCMs on GM, and highlights that remarkable capacity of TCMs to restore GM after damage.Results: These TCMs preparations promote the repair of multicomponent targets such as the gastric mucus, epithelial layer, blood flow (GMBF) and lamina propria barrier.Summary: Overall, this study has summarized the essential regulatory mechanisms and pharmacological efficacy of TCMs on new and productive therapeutic targets.Discussion: This review provides an avenue for studying various drugs with potentially promising effects on mucosal integrity, as well as subsequent pharmacological studies, clinical applications, and new drug development.

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Pathophysiological role of ion channels and transporters in gastrointestinal mucosal diseases

Cited by 14 publications

References 205 publications

Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

The Ion Channels Involved in Oxidative Stress-Related Gastrointestinal Diseases

Pharmacological targeting of gastric mucosal barrier with traditional Chinese medications for repairing gastric mucosal injury

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