Pathophysiological Contribution of Vascular Function to Baroreflex Regulation in Hypertension

Tomiyama, Hirofumi; Matsumoto, Chisa; Kimura, Kana; Odaira, Mari; Shiina, Kazuki; Yamashina, Akira

doi:10.1253/circj.cj-14-0064

Cited by 23 publications

(12 citation statements)

References 37 publications

(21 reference statements)

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“…According to pulse wave velocity assessments in normotensive and hypertensive patients, atherosclerosis was significantly independently associated with reduced BRS. [28][29][30] Recently, we reported that the cardio-ankle vascular index, an indicator of arteriosclerosis, was independently associated with BRS. 31) In a carotid bulb containing highly concentrated baroreceptors, increased intima-media thickness was also reportedly associated with reduced BRS.…”

Section: Clinical Features Of Reduced Baroreflex Sensitivitymentioning

confidence: 99%

Clinical Implications of Baroreflex Sensitivity in Type 2 Diabetes

Sakamoto

Matsutani

Kayama³

2019

Int. Heart J.

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The evaluation of baroreflex sensitivity (BRS), which maintains systemic circulatory homeostasis, is an established tool to assess cardiovascular autonomic neuropathy in type 2 diabetes mellitus (T2DM). As BRS plays an important function in blood pressure regulation, reduced BRS leads to an increase in blood pressure variability, which further leads to reduced BRS. This sequence of events becomes a vicious cycle. The major risk factors for reduced BRS are T2DM and essential hypertension, but many other risk factors have been reported to influence BRS. In recent years, reports have indicated that glycemic variability (GV), such as short-and longterm GV that are considered important risk factors for macrovascular and microvascular complications, is involved in reductions in BRS independently of blood glucose levels. In this review, we discuss reduced BRS in T2DM, its features, and the potential for its reversal.(Int Heart J 2019; 60: 241-246)

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Section: Clinical Features Of Reduced Baroreflex Sensitivitymentioning

confidence: 99%

Clinical Implications of Baroreflex Sensitivity in Type 2 Diabetes

Sakamoto

Matsutani

Kayama³

2019

Int. Heart J.

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“…2-4 Attenuation of baroreflex sensitivity (BRS) in carotid atherosclerosis is likely to result from the reduced distensibility of carotid bulbs infiltrated by atherosclerosis. 5, 6 Also, it is possible that impaired BRS can accelerate atherosclerosis through inflammation and endothelial cell changes. 7, 8 Baroreflex and Cerebral Autoregulation of ABP was achieved using a servo-controlled finger plethysmograph (Finapres, Ohmeda, CO, USA for patients with carotid stenosis; and Nexfin, BMI for volunteers).…”

mentioning

confidence: 99%

Baroreflex and Cerebral Autoregulation Are Inversely Correlated

Nasr

Czosnyka

Traon

et al. 2014

Circ J

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“…36 This decrease augments BP fluctuations. Mancia et al reported that carotid arterial remodeling is associated with vvBPV abnormalities.…”

Section: Resultsmentioning

confidence: 95%

Obstructive Sleep Apnea as Possible Causal Factor for Visit-to-Visit Blood Pressure Variability

Shiina

Tomiyama

Takata

et al. 2016

Circ J

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Background: Recent studies have shown that visit-to-visit blood pressure variability (BPV) is an independent risk factor for cardiovascular disease. However, it has not been clarified whether obstructive sleep apnea (OSA) is associated with visit-to-visit BPV. Methods and Results:The 56 subjects with OSA and 26 control subjects without OSA were examined. Office BP was measured on 5 separate consecutive occasions prior to a polysomnography examination. The visit-to-visit BPV was expressed as the standard deviation and the coefficient of variation of the 5 systolic BP measurements. In subjects with an apnea-hypopnea index (AHI) of more than 20 episodes per hour, the visit-to-visit BPV was also measured after the start of continuous positive airway pressure (CPAP) therapy. Overall, the AHI positively correlated with the standard deviation and the coefficient of variation of systolic BP. In a multivariate analysis, the plasma noradrenaline level and the AHI were independently and positively correlated with the standard deviation and the coefficient of variation of the systolic BP. Among the patients who underwent CPAP therapy, good adherence with CPAP therapy significantly reduced the visit-to-visit BPV. Conclusions:OSA is associated with abnormal visit-to-visit BPV and sympathetic activation seems to be related in some way. (Circ J 2016; 80: 1787 -1794

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Pathophysiological Contribution of Vascular Function to Baroreflex Regulation in Hypertension

Cited by 23 publications

References 37 publications

Clinical Implications of Baroreflex Sensitivity in Type 2 Diabetes

Clinical Implications of Baroreflex Sensitivity in Type 2 Diabetes

Baroreflex and Cerebral Autoregulation Are Inversely Correlated

Obstructive Sleep Apnea as Possible Causal Factor for Visit-to-Visit Blood Pressure Variability

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