Pathology of small-cell lung cancer

Junker, Klaus; Wiethege, Thorsten; Müller, Klaus

doi:10.1007/pl00008483

Cited by 61 publications

(35 citation statements)

References 6 publications

(7 reference statements)

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“…Los carcinomas indiferenciados de célula pequeña primarios del colon y recto son raros y se parecen morfológicamente a los del pulmón (6). La localización anatómica más frecuente de estos tumores es el ciego, recto y sigma, siendo la localización anal de estos tumores NE rara y de mal pronóstico (1,2,5,7).…”

Section: Discussionunclassified

Carcinomas neuroendocrinos de colon y recto: Experiencia de una unidad en seis años

Vilallonga

Basany

Cano

et al. 2008

Rev. esp. enferm. dig.

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INTRODUCCIÓNEl hallazgo de un tumor neuroendocrino (NE) en el colon o recto es poco frecuente pese a que las células neuroendocrinas están distribuidas en todo el organismo (1). Vol. 100. N.°1, pp. 11-16, 2008 Recibido: 30-08-07. Aceptado: 24-10-07. RESUMENIntroducción: los tumores neuroendocrinos de colon y recto son poco frecuentes. Suelen ser tumores poco diferenciados, diagnosticados por el patólogo y de especial agresividad en su comportamiento clínico. El pronóstico suele ser malo, con tendencia a la rápida metastatización.Material y métodos: se ha revisado la experiencia de una Unidad de Coloproctología durante un periodo de seis años. Se han revisado de manera retrospectiva los pacientes con un tumor de estirpe neuroendocrina. Se han excluido los tumores carcinoides.Resultados: durante este periodo, se han intervenido 2.155 pacientes por cáncer de colon y recto y se han hallado cinco pacientes con tumores neuroendocrinos. La edad media fue de 66 años, tres varones y dos hembras. Se localizaron uno en ciego, dos en recto y dos en sigma. Dos pacientes presentaban diseminación del tumor a distancia. Se realizó cirugía en todos los pacientes con quimioterapia posterior en dos de ellos. Un paciente falleció por insuficiencia hepática postoperatoria, otro a los dos meses y otro al año. Dos pacientes siguen vivos con un seguimiento medio de ocho meses.Conclusiones: los tumores neuroendocrinos son unos tumores de aparición rara en el colon y recto. La clínica de presentación no difiere de la que podrían tener los adenocarcinomas. En el momento del diagnóstico estos tumores suelen presentar enfermedad a distancia, como en dos de los cinco casos presentados, relacionándose con un mal pronóstico para el enfermo. El tratamiento quirúrgico y quimioterápico combinado es el que puede alargar más la supervivencia de los pacientes.Palabras clave: Tumor. Neuroendocrino. Colon. Recto. Carcinoma indiferenciado. ABSTRACTIntroduction: neuroendocrine tumours of the colon and rectum are infrequent. They are usually undifferentiated, easy to diagnose for the pathologist and are especially aggressive in their clinical behaviour. Prognosis is usually poor and they have a high tendency to metastase early.Material and methods: we have reviewed our experience in a Colorectal Unit during a period of six years. Patients with neuroendocrine tumours have been reviewed retrospectively. Carcinoid tumours have not been included in this study.Results: during this period, 2,155 patients have been operated for colorectal cancer and in five patients a neuroendocrine tumour has been found in the specimen. Mean age was 66 years, three male and two female. One tumour was located in the caecum, two in the rectum and two in the sigmoid colon. Two patients had hepatic metastasis at diagnosis. Surgery was performed in all patients and two patients received adjuvant quimiotherapy. A patient died because of post-operative hepatic insufficiency, another at 2 months and another after one year. Two patients are still alive after eight months' follow-u...

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Section: Discussionunclassified

Carcinomas neuroendocrinos de colon y recto: Experiencia de una unidad en seis años

Vilallonga

Basany

Cano

et al. 2008

Rev. esp. enferm. dig.

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“…They display a high mitotic rate and biopsies often include considerable numbers of necrotic cells. SCLC cells are fragile, resulting in typical ''crush [20] classifies SCLC as a neuroendocrine tumour. This is clinically relevant, as paraneoplastic neuroendocrine symptoms are often the first sign of SCLC.…”

Section: Biology Of Sclcmentioning

confidence: 99%

Update on small cell lung cancer management

Huber¹,

Tufman²

2012

Breathe

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SummarySmall cell lung cancers (SCLCs) account for ,15-20% of all lung cancers. Because SCLC is almost always associated with long-term tobacco smoking, abstinence from smoking and smoking cessation are crucial for primary prevention. Because symptoms are generally unspecific, the disease is often diagnosed late, with 70% of patients already in stage IIIb or IV at the time of diagnosis. Early detection of SCLC through screening is under investigation. Chemotherapy, generally a platinum-based combination, is the mainstay of therapy and is generally combined with radiation in the first-line treatment of tumours up to stage IIIb. Surgery has a place in the diagnosis and therapy of stage I SCLC, but plays no key role in advanced cancer. In patients who respond to first-line therapy, prophylactic cranial irradiation can prevent brain metastases and improve overall survival. Although the initial response to treatment is usually good, SCLC tends to relapse quickly. This makes second-line therapy quite important. Topotecan is the most studied and widely used agent in second-line therapy; however, newer agents, including biological therapies, are under study. Statement of interestNone declared.HERMES syllabus links: module B. 2. 1

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“…Small cell carcinoma of the lung is highly malignant and has a poor prognosis (Junker et al, 2000). Patients with neuroendocrine carcinoma of gastrointestinal origin have also had metastases at the time of diagnosis.…”

Section: Introductionmentioning

confidence: 99%