Pathology of radiation-induced coronary artery disease in human and pig

Virmani, Renu; Farb, Andrew; Carter, Andrew J.; Jones, Russell M.

doi:10.1016/s1522-1865(98)00010-9

Cited by 94 publications

(68 citation statements)

References 6 publications

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“…We have shown that this cellular recanalization process that occurs between 10 and 14 days of occlusion in our animal model is inhibited by low activities of 32 P. Although 32 P stents have been designed to inhibit restenosis, numerous animal studies have shown a paradoxical increase in neointimal thickness with low-dose stents. 17,18 Endothelialization of the clot formed on the surface of the device may be involved in decreasing neointima thickness following arterial implantation of stents. Inhibition of endothelialization by beta radia- .…”

Section: Discussionmentioning

confidence: 99%

In Situ Beta Radiation to Prevent Recanalization After Coil Embolization of Cerebral Aneurysms

Raymond

Leblanc

Desfaits

et al. 2002

Stroke

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Background and Purpose-Endovascular treatment of cerebral aneurysms, a minimally invasive alternative to surgery, is too often followed by recanalization and recurrences. The purpose of this work was to assess if in situ beta radiation can inhibit recanalization after coil embolization. Methods-Radioactive platinum coils ( 32 P-coils) were produced by ion implantation of 32 P. A single-coil arterial occlusion model was used to compare angiographic and pathological results at 1 to 12 weeks after nonradioactive and 32 P-coil embolization of maxillary, cervical, and vertebral arteries in 26 dogs. Coils of varying activities were used and results compared to define the minimal activity required to inhibit recanalization. Similar experiments were performed in 16 porcine maxillary and lingual and 8 rabbit axillary arteries. Results of 32 P-coil embolization of bifurcation aneurysms were then compared with embolization with nonradioactive coils in 12 dogs at 3 months. Results-Nonradioactive coil embolization of canine arteries led to occlusion at 1 week, followed by recanalization at 2 weeks, which persisted at 3 months in all cases. 32 P-coils, ion-implanted with activities above 0.13 Ci/cm, led to persistent occlusion at 3 months in 80% of arteries.32 P-coils ion-implanted with the same activity inhibited recanalization in porcine and rabbit arteries. Bifurcation aneurysms treated with 32 P-coils had better angiographic results at 3 months (Pϭ0.006) than aneurysms treated with nonradioactive coils. Arteries occluded were filled with fibrous tissue at 3 months. Aneurysms embolized with 32 P-coils showed more complete neointimal coverage of the neck, without recanalization, as compared with aneurysms treated with nonradioactive coils. Conclusion-In

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Section: Discussionmentioning

confidence: 99%

In Situ Beta Radiation to Prevent Recanalization After Coil Embolization of Cerebral Aneurysms

Raymond

Leblanc

Desfaits

et al. 2002

Stroke

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“…Radioterapia powyżej przepony, a w niektórych grupach pacjentów również poniżej przepony może się wiązać z większą zapadalnością na chorobę niedokrwienną serca ze względu na rozwój nasilonej choroby miażdżycowej i niemiażdżycowej, powikłanej pękaniem blaszek miażdżyco-wych i zakrzepicą, a potencjalnie również skurczem naczyń wieńcowych [126][127][128][129][130][131]. Częstym i potencjalnie zagrażają-cym życiu powikłaniem są zwężenia ostialne.…”

Section: Radioterapiaunclassified

2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines

Zamorano¹,

Lancellotti²,

Muñoz³

et al. 2016

Kardiol Pol

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“…A review of clinical records from United States Army personnel irradiated for mediastinal malignancies concluded that radiation-induced intimal plaque was similar to classical atherosclerotic coronary disease, although medial thinning and adventitial fibrosis were more prominent after irradiation. 16 Several anecdotal reports identify fibrosis and ischemia of irradiated vessel walls, rather than accumulation of lipidfilled foam cells, but this may well reflect the presence of end-stage atherosclerosis and healed ruptured plaques. Systematic data on composition and stability of early radiation-induced atherosclerosis and its progression are lacking.…”

mentioning

confidence: 99%

Ionizing Radiation Accelerates the Development of Atherosclerotic Lesions in ApoE−/− Mice and Predisposes to an Inflammatory Plaque Phenotype Prone to Hemorrhage

Stewart

Heeneman

Poele

et al. 2006

The American Journal of Pathology

246

160

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After radiotherapy treatment, there is an increased incidence of localized atherosclerosis in patients with Hodgkin's disease, breast cancer, and head and neck cancer. Here, we established a mouse model to study the development and progression of radiation-induced atherosclerosis and to compare the phenotype of these lesions with age-related atherosclerosis. Atherosclerosis-prone ApoE ؊/؊ mice fed a regular chow diet received single radiation doses of 14 Gy or sham treatments (0 Gy) to the neck, including both carotid arteries. At 22, 28, and 34 weeks after irradiation, blood samples were taken, and the arterial tree was removed for histological examination. Cholesterol levels in irradiated mice were not significantly different from agematched controls, and markers of systemic inflammation (soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, and C-reactive protein) were not elevated. Earlier diagnosis and better treatment options have lead to improvements in cancer-specific survival for most tumor types, but this also results in an increased number of patients at risk for developing treatment-related side effects. At least one-half of all cancer survivors will have received radiotherapy during their treatment, and vascular injury is the major cause of late radiation morbidity.A meta-analysis of radiotherapy trials for women with early breast cancer showed that the benefit of radiotherapy (5% reduction in cancer related deaths) was offset by a 4% increase in non-breast-cancer-related mortality, mainly late vascular disease that became apparent with longer follow-up.

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Pathology of radiation-induced coronary artery disease in human and pig

Cited by 94 publications

References 6 publications

In Situ Beta Radiation to Prevent Recanalization After Coil Embolization of Cerebral Aneurysms

In Situ Beta Radiation to Prevent Recanalization After Coil Embolization of Cerebral Aneurysms

2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines

Ionizing Radiation Accelerates the Development of Atherosclerotic Lesions in ApoE−/− Mice and Predisposes to an Inflammatory Plaque Phenotype Prone to Hemorrhage

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