Pathology of Nasal Infection caused by Conidiobolus lamprauges and Pythium insidiosum in Sheep

Epidemiological, clinical and diagnostic aspects of sheep conidiobolomycosis in Brazil

“…Table 2 shows that the predominant clinical presentation in sheep conidiobolomycosis outbreaks reported in Brazil was nasopharyngeal. It was also observed that in the described outbreaks, both clinical forms of the disease did not occur concurrently, except in a single outbreak (UBIALI et al, 2013). In these outbreaks, the main species identified were C. lamprauges and C. coronatus.…”

“…In these outbreaks, the main species identified were C. lamprauges and C. coronatus. According to UBIALI et al (2013) infections caused by C. lamprauges were mainly related to nasopharyngeal form. Nevertheless, the same authors reported C. lamprauges in both clinical forms of sheep in Mato Grosso state.…”

“…Serological and molecular diagnosis UBIALI et al (2013) utilized immunohistochemistry with polyclonal serum to perform a differential diagnosis of granulomatous rhinitis in sheep. Previously, SILVA et al (2010) used this technique to confirm the fungal etiology of conidiobolomycosis in ovine.…”

“…In sheep, pathogenic Conidiobolus and Pythium insidiosum may be associated with rhinofacial rhinitis and nasopharyngeal infection; however, it is observed that conidiobolomycosis lesions in general are associated with the nasopharynx and these lesions have an aspect of a yellow or white firm mass (AGUIAR et al, 2014). In contrast, pythiosis is associated with the rhinofacial region with production of necrotic and friable tissues (SANTURIO et al, 2008;UBIALI et al, 2013). Additionally, significant morphological differences are observed among the lesions caused by both microorganisms.…”

“…Conidiobolomycosis shows an evident pattern of multifocal granulomatous lesion with wide hyphae (diameter of 7-30µm) surrounded by an abundant amount of Splendori-Hoeppli material. Again, in contrast, in pythiosis there is a marked caseous necrosis and thinner hyphae when compared to hyphae of pathogenic Conidiobolus, and surrounded by discrete Splendori-Hoeppli reaction (RIET-CORREA et al, 2008;PORTELLA et al, 2010;UBIALI et al, 2013).…”