1997
DOI: 10.1046/j.1365-2559.1997.5460776.x
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Abstract: The diagnosis of malignant mesothelioma can pose several problems to the surgical pathologist. First, the morphological appearances of the tumour are known to be diverse with mimicry of a range of both reactive and neoplastic conditions. Second, due to the relative inaccessibility of the serosa, biopsy material is often scanty and fragmentary, producing a plethora of interpretive ambiguities. Third, adjunct techniques such as mucin histochemistry and immunohistochemistry, whilst useful in excluding malignant m… Show more

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Cited by 229 publications
(182 citation statements)
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“…A number of immunohistochemical markers have been proposed to assist conventional morphological diagnosis, including epithelial membrane antigen (EMA) 2-5 p53 protein, [2][3][4][5][6][7][8][9][10][11] and P-glycoprotein. 2,5,12 Other markers tested have included Bcl-2, 2,3,13 platelet-derived growth factor receptor (PDGF-R) bchain 2,5,8 and desmin.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…A number of immunohistochemical markers have been proposed to assist conventional morphological diagnosis, including epithelial membrane antigen (EMA) 2-5 p53 protein, [2][3][4][5][6][7][8][9][10][11] and P-glycoprotein. 2,5,12 Other markers tested have included Bcl-2, 2,3,13 platelet-derived growth factor receptor (PDGF-R) bchain 2,5,8 and desmin.…”
mentioning
confidence: 99%
“…2,5,12 Other markers tested have included Bcl-2, 2,3,13 platelet-derived growth factor receptor (PDGF-R) bchain 2,5,8 and desmin. 2 To date, however, no single immunohistochemical marker that can unequivocally discriminate RM from MPM has been available.…”
mentioning
confidence: 99%
“…To resolve this dilemma, most pathologists have used a combination of histochemical staining for neutral mucins, which is positive in up to 75% of cases of adenocarcinoma (1), and immunohistochemical staining using antibodies with high specificity and sensitivity for adenocarcinoma (2)(3)(4). Therefore, until recently, most laboratories have accepted that a negative result from a panel of adenocarcinomaassociated antibodies, usually taken from BerEP4 (5), CEA (6), AUA1 (7), Bg8 (4), Leu-M1 (8), B72.3 (9 -11), and anti-MOC-31 (12), together with a negative staining for neutral mucins, indicates mesothelioma.…”
mentioning
confidence: 99%
“…There are three major types-epithelioid type, sarcomatoid type and biphasic type-and the proportion of each is approximately 60, 20 and 20%, respectively (Figs. 1, 2, 3) [7]. The desmoplastic type is rare (probably 1-2%) (Fig.…”
Section: Histology Of Mesotheliomamentioning
confidence: 95%