Pathology of Jugular Foramen Neurofibroma

Abstract

Tumors of jugular foramen may closely resemble glomus jugulare tumors clinically and radiographically. A tissue diagnosis is necessary to make a differentiation of these tumors. This conclusion is supported by the findings in a temporal bone from a patient who was diagnosed clinically as having a glomus jugulare tumor 57 years before her death at the age of 84 years. Compression of the 7th and 8th cranial nerves in the internal auditory canal and the 10th and 11th cranial nerves at the jugular foramen represents the mechanism of neural signs produced by a neurofibroma arising in the jugulare foramen. This case further demonstrates that conservative treatment of benign extradural tumors may be compatible with a long and useful life.

Development of a schwannoma within a facial nerve neurofibroma: A case report and literature review

“…They may stimulate acoustic tumors or appear as parotid masses with or without facial palsy 2 . Neurofibromas found within the jugular foramen may closely mimic glomus jugulare tumors, and tissue diagnosis may be necessary for differentiation 3 …”

“…2 Neurofibromas found within the jugular foramen may closely mimic glomus jugulare tumors, and tissue diagnosis may be necessary for differentiation. 3 Histologically, schwannomas are chäracterized by a well-circumscribed capsule. They are usually firm to palpation.…”

Plexiform neurofibroma of the cervical portion of the vagus nerve

“…A neurofibroma of the cervical portion of the vagus nerve is a rare tumour; it occurs in both males and females, more frequently in the right side and in subjects aged between 10 and 80 years with two peaks around 30 and 55 years (Krueger et al, 1979;Gacek et al, 1983).…”

Carcinoma of temporal bone, base of the skull: Diagnosis by needle aspiration cytology

“…There was ipsilateral paralysis of the seventh (facial) nerve, peripheral type, presumably related to involvement of the facial canal of the temporal bone, and paralysis of the ninth, tenth, and twelfth cranial nerves, with right tongue and pharyngeal paralysis related to involvement of emerging cranial nerves at the jugular fossa. [1][2][3][4] The symptoms were of approximately 6-mo duration, during which period there was weight loss and right otalgia with progressive deafness and periodic aural discharge with Pseudomonas aeruginosa cultured. A CT scan of the internal organs disclosed liver involvement consistent with neoplasia, probably metastatic, suggested by the presence of multiple lesions in the right lobe, with one being larger in size.…”