Pathology of Hereditary Juvenile Retinoschisis

Retinal nerve fibre layer thickness analysis in X-linked retinoschisis using Fourier-domain OCT

“…Also, our finding of RNFL thinning is in agreement with previous studies by Manschot and Condon et al,11-12 which described optic nerve atrophy in XLRS patients. Using a time-domain scanning procedure of the macula, Apushkin et al,17 did not observe any thinning of the papillo-macular bundle RNFL thickness on OCT imaging in patients with juvenile XLRS and no clinical findings of optic disc pallor.…”

Retinal nerve fibre layer thickness analysis in X-linked retinoschisis using Fourier-domain OCT

“…Also, our finding of RNFL thinning is in agreement with previous studies by Manschot and Condon et al,11-12 which described optic nerve atrophy in XLRS patients. Using a time-domain scanning procedure of the macula, Apushkin et al,17 did not observe any thinning of the papillo-macular bundle RNFL thickness on OCT imaging in patients with juvenile XLRS and no clinical findings of optic disc pallor.…”

X-Linked Retinoschisis in Juveniles: Follow-Up by Optical Coherence Tomography

“…The GCL was also frequently affected (83.3%). These results are supported by previous pathology based studies, which demonstrated that inner retinal abnormalities were the main manifestation of XLRS [ 10 , 11 ].…”

Comprehensive analysis of genetic and clinical characteristics of 30 patients with X‐linked juvenile retinoschisis in China

“…Exudation and IRB are not rare in XLRS and may occur from the wrinkling or traction of macular detachment, abnormal vascular proliferation, or traction of VVs (Hu et al 2017 ; Wood et al 2019 ). Neovascular glaucoma has also previously been reported in XLRS (Ando et al 2000 ), and with some studies attributing it to RD or extensive schisis (Manschot 1972 ), while others report that ischaemia in ocular tissues is the main cause (Ando et al 2000 ). Although we did not observe neovascular glaucoma in our study, we detected two cases with POAG and one with PCAG; current information is insufficient to determine whether they are complication or simply coexist with XLRS.…”

Retinal nerve fibre layer thickness analysis in X-linked retinoschisis using Fourier-domain OCT

“…Also, our finding of RNFL thinning is in agreement with previous studies by Manschot and Condon et al,11-12 which described optic nerve atrophy in XLRS patients. Using a time-domain scanning procedure of the macula, Apushkin et al,17 did not observe any thinning of the papillo-macular bundle RNFL thickness on OCT imaging in patients with juvenile XLRS and no clinical findings of optic disc pallor.…”

X-Linked Retinoschisis in Juveniles: Follow-Up by Optical Coherence Tomography

“…The GCL was also frequently affected (83.3%). These results are supported by previous pathology based studies, which demonstrated that inner retinal abnormalities were the main manifestation of XLRS [ 10 , 11 ].…”

Comprehensive analysis of genetic and clinical characteristics of 30 patients with X‐linked juvenile retinoschisis in China

“…Exudation and IRB are not rare in XLRS and may occur from the wrinkling or traction of macular detachment, abnormal vascular proliferation, or traction of VVs (Hu et al 2017 ; Wood et al 2019 ). Neovascular glaucoma has also previously been reported in XLRS (Ando et al 2000 ), and with some studies attributing it to RD or extensive schisis (Manschot 1972 ), while others report that ischaemia in ocular tissues is the main cause (Ando et al 2000 ). Although we did not observe neovascular glaucoma in our study, we detected two cases with POAG and one with PCAG; current information is insufficient to determine whether they are complication or simply coexist with XLRS.…”

Retinal nerve fibre layer thickness analysis in X-linked retinoschisis using Fourier-domain OCT

“…Also, our finding of RNFL thinning is in agreement with previous studies by Manschot and Condon et al,11-12 which described optic nerve atrophy in XLRS patients. Using a time-domain scanning procedure of the macula, Apushkin et al,17 did not observe any thinning of the papillo-macular bundle RNFL thickness on OCT imaging in patients with juvenile XLRS and no clinical findings of optic disc pallor.…”

X-Linked Retinoschisis in Juveniles: Follow-Up by Optical Coherence Tomography

“…The GCL was also frequently affected (83.3%). These results are supported by previous pathology based studies, which demonstrated that inner retinal abnormalities were the main manifestation of XLRS [ 10 , 11 ].…”

Comprehensive analysis of genetic and clinical characteristics of 30 patients with X‐linked juvenile retinoschisis in China

“…Exudation and IRB are not rare in XLRS and may occur from the wrinkling or traction of macular detachment, abnormal vascular proliferation, or traction of VVs (Hu et al 2017 ; Wood et al 2019 ). Neovascular glaucoma has also previously been reported in XLRS (Ando et al 2000 ), and with some studies attributing it to RD or extensive schisis (Manschot 1972 ), while others report that ischaemia in ocular tissues is the main cause (Ando et al 2000 ). Although we did not observe neovascular glaucoma in our study, we detected two cases with POAG and one with PCAG; current information is insufficient to determine whether they are complication or simply coexist with XLRS.…”