Pathology and pathogenesis of human leptospirosis: a commented review

Brito, Thales de; Silva, Ana Maria Gonçalves da; Abreu, Patrícia Antonia Estima

doi:10.1590/s1678-9946201860023

Cited by 56 publications

(65 citation statements)

References 41 publications

(65 reference statements)

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“…Leptospira antigens present in muscle sarcoplasm during active infection, creating an immunological target that produces myositis and elevated creatinine kinase. 2 Resultant myoglobinuria may also contribute to renal failure, but this conjecture requires further study. 18 Leptospirosis is underdiagnosed because physicians lack clinical suspicion, symptomatology varies, reporting systems are poor, and serological testing is usually expensive and time-consuming.…”

Section: Discussionmentioning

confidence: 99%

“…Rhabdomyolysis in this patient is also characteristic of leptospirosis. Leptospira antigens present in muscle sarcoplasm during active infection, creating an immunological target that produces myositis and elevated creatinine kinase . Resultant myoglobinuria may also contribute to renal failure, but this conjecture requires further study …”

Section: Discussionmentioning

confidence: 99%

“…Humans can remain asymptomatic and disseminate Leptospira into the environment for up to 1 year. 2 Leptospirosis is common to an array of tropical climates but also poses a risk to low socioeconomic populations in city areas. [5][6][7] Among symptomatic patients, one study suggests that the mortality rate for untreated leptospirosis ranges between 0% and 40% (median 2.2%).…”

Section: Discussionmentioning

confidence: 99%

“…Based on a systematic review of published mortality and morbidity studies, it is estimated the global burden of leptospirosis is 1.03 million cases each year . While disease manifestation may be mild or asymptomatic, severe disease can present with multiorgan dysfunction including liver failure, renal failure, pulmonary hemorrhage, vascular damage, and muscle lesions . One of the classic manifestations of leptospirosis is Weil's disease—the combination of hemorrhagic events, jaundice, and acute renal failure—first observed by Adolf Weil in 1886 .…”

Section: Introductionmentioning

confidence: 99%

“…1 While disease manifestation may be mild or asymptomatic, severe disease can present with multiorgan dysfunction including liver failure, renal failure, pulmonary hemorrhage, vascular damage, and muscle lesions. 2 One of the classic manifestations of leptospirosis is Weil's disease-the combination of hemorrhagic events, jaundice, and acute renal failure-first observed by Adolf Weil in 1886. 3 We present a case of a 61-year-old homeless New Yorker complaining of abdominal pain who was found to have acute pancreatitis, myositis, and portal vein thrombosis due to leptospirosis in addition to renal failure and hepatic dysfunction.…”

Section: Introductionmentioning

confidence: 99%

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