2018
DOI: 10.1590/s1678-9946201860023
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Has erratum 2018-6-28
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Abstract: Leptospirosis is an acute bacterial septicemic febrile disease caused by pathogenic leptospires, which affect humans and animals in all parts of the world. Transmission can occur by direct contact with infected animals or, more commonly, through indirect contact with water or soil contaminated with urine from infected animals. Leptospires enter the body by penetrating mucous membranes or skin abrasions and disseminate through the hematogenic route. In humans, leptospirosis may cause a wide spectrum of symptoms… Show more

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Cited by 60 publications
(75 citation statements)
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References 41 publications
(65 reference statements)
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“…Leptospira antigens present in muscle sarcoplasm during active infection, creating an immunological target that produces myositis and elevated creatinine kinase. 2 Resultant myoglobinuria may also contribute to renal failure, but this conjecture requires further study. 18 Leptospirosis is underdiagnosed because physicians lack clinical suspicion, symptomatology varies, reporting systems are poor, and serological testing is usually expensive and time-consuming.…”
Section: Discussionmentioning
confidence: 99%
See 4 more Smart Citations
“…Leptospira antigens present in muscle sarcoplasm during active infection, creating an immunological target that produces myositis and elevated creatinine kinase. 2 Resultant myoglobinuria may also contribute to renal failure, but this conjecture requires further study. 18 Leptospirosis is underdiagnosed because physicians lack clinical suspicion, symptomatology varies, reporting systems are poor, and serological testing is usually expensive and time-consuming.…”
Section: Discussionmentioning
confidence: 99%
“…Rhabdomyolysis in this patient is also characteristic of leptospirosis. Leptospira antigens present in muscle sarcoplasm during active infection, creating an immunological target that produces myositis and elevated creatinine kinase . Resultant myoglobinuria may also contribute to renal failure, but this conjecture requires further study …”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations