Pathology and genetics of meningiomas

Alahmadi, Hussein; Croul, Sidney

doi:10.1053/j.semdp.2011.01.002

Cited by 34 publications

(22 citation statements)

References 70 publications

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“…Low-grade meningiomas have a benign biology and total excision seems to be a sufficient treatment for this group of brain tumors. However, alm.ost 5% of all tumors recur within the 45 months, some may progress into high-grade meningiomas [6,16]. Lack of the markers of recurrence leads to the doubts associated with the prognosis of low-grade meningiomas.…”

Section: Discussionmentioning

confidence: 99%

“…Most cases are low-grade meningiomas, which have a benign biology without tendency to recur. However sometimes, even after seemingly complete resection, some of the low-grade cases may recur [6,7]. Atypical and anaplastic meningiomas occur more commonly in older man and are associated with poor prognosis, including brain or skull invasion.…”

Section: Introductionmentioning

confidence: 99%

“…Atypical and anaplastic meningiomas occur more commonly in older man and are associated with poor prognosis, including brain or skull invasion. The most reliable histological futures that correlate with recurrence risk are an increased mitotic activity, nuclear pleomorphism and necrosis [6].…”

Section: Introductionmentioning

confidence: 99%

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The expression of hypoxia-inducible factor-1 in primary brain tumors

Reszeć

Rutkowski

Chyczewski

2013

International Journal of Neuroscience

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Purpose: Primary brain fumors are common type of neoplasms. Tine mosf common are asfrocyfic fumors, so do meningiomas of various grades. The efioiogy is stiii unknown; iiowever, there are iofs of dafa presenting new fheories about genefic alferafions responsible for low-or high-grade asfrocytic tumors development as well as meningiomas, despite this the results are divergent. The aim of fhe study was to evaluate hypoxia-inducible facfor-1 (HIF-1) expression in meningiomas and asfrocytic tumors of various grades. Material and methods: One hundred six cases of astrocytic tumors were divided into diffused astrocyfoma (24 cases), anapiasfic astrocyfoma (40 cases) and glioblastoma groups (42 cases). Among gliobiasfoma group, 30 cases were secondary gliobiastoma. One hundred fiffy-four meningioma cases were divided as low-grade meningioma (G1 :104 cases) and high-grade meningioma groups (G2:43 cases and G3:7 cases). Twelve low-grade meningiomas transformed into high-grade tumors, 17 low-grade meningiomas recur within 12 years. HIF-1 expression was estimated using immunohistochemistry under the light microscope. Statistical analysis was performed in all examined groups. Results: HIF-1 expression was observed in 37.5% cases of diffused astrocytomas, in anaplastic astrocytomas 27.5% tumors were HIF-1 positive, in the giioblasfoma goup HIF-1 expression was observed in 83.3% cases. All secondary glioblastomas were positive for HIF-1. Low-grade meningiomas were posifive for HIF-1 in 55.7%, in high-grade meningiomas, HIF-1 expression was observed in 84%. All meningiomas, which progressed from low-to high-grade meningiomas, were HIF-1 positive. Conclusion: HIF-1 expression is associated with the development and progression of both astrocyfic tumors and meningiomas.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The expression of hypoxia-inducible factor-1 in primary brain tumors

Reszeć

Rutkowski

Chyczewski

2013

International Journal of Neuroscience

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“…A 5-µm sections were stained with haematoxylin and eosin (H&E). All histological and immunohistochemical (IHC) tumor slides were evaluated by experienced pathologist (G. F.), and regrouped as benign, atypical, and anaplastic meningiomas according to the WHO classification of tumors of the central nervous system (3).…”

Section: Methodsmentioning

confidence: 99%

“…Although most meningiomas are benign, they have a surprisingly broad spectrum of clinical characteristics and histologically distinct subsets are associated with high risk of recurrence, even after complete resection. In rare instances, meningiomas are malignant [3]. About 80% meningiomas are slow-growing tumors of WHO grade I, and most commonly diagnosed histological subtypes are meningothelial, fibrous and transitional meningioma.…”

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confidence: 99%

Expression of ki-67 and p53 in meningiomas

Pavelin¹,

Bečić²,

Forempoher³

et al. 2013

neo

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Meningiomas account for about 30% of all primary brain tumors. It is difficult to predict the behaviour of meningiomas, and identification of protein markers responsible for the regulation of cell proliferation can be very helpful. The aim of this study was to evaluate immunohistochemical expression of Ki-67 and p53 in 170 meningiomas.A total number of 170 meningioma samples were classified according to WHO, immunohistochemicaly stained for Ki-67 and p53 and analysed using light microscope.Of 170 meningiomas analysed, 142 were grade I, 17 grade II and 11 grade III. Female to male ratio was 1.42:1. Statistically significant correlation was found between tumor grade and Ki-67 (p<0.001). There was significant correlation between Ki-67 levels and tumor subtypes (p=0.009). The optimal cut-off value for Ki-67 was 3.195. Tumors with Ki-67 ≤3.195 were 2 cm smaller than tumors with Ki-67 >3.195. Statistically significant correlation was found regarding p53 expression and tumor size (p=0.034). No correlation was established between Ki-67 or p53 and location of the tumor.According to positive correlation between tumor grade and subtype with Ki-67 levels, as well as positive correlation between Ki-67 and p53 with tumor size, indicate that Ki-67 and p53 might have influence on meningioma development and progression.

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Molecular Pathology of the Central Nervous System

Harris

Hattab

2012

Molecular Surgical Pathology

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Pathology and genetics of meningiomas

Cited by 34 publications

References 70 publications

The expression of hypoxia-inducible factor-1 in primary brain tumors

The expression of hypoxia-inducible factor-1 in primary brain tumors

Expression of ki-67 and p53 in meningiomas

Molecular Pathology of the Central Nervous System

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