Pathological changes in kidneys of dogs with natural Leishmania infection

Nieto, C. G.; Navarrete, Ignacio; Habela, M.; Serrano, Francisco; Redondo, E.

doi:10.1016/0304-4017(92)90025-5

Cited by 81 publications

(79 citation statements)

References 13 publications

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“…Histopathological findings in the three analyzed dogs (Animals #2, #8 and #20) were in accordance with those described by various authors in cases of leishmaniasis [8,15,23,26,31,36], and corresponded to glomerulonephritis and interstitial nephritis (Fig. 5).…”

Section: Discussionsupporting

confidence: 88%

SDS-PAGE and Western blot of urinary proteins in dogs with leishmaniasis

et al. 2003

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-Canine leishmaniasis is an endemic disease in the Mediterranean area caused by the protozoan Leishmania infantum, which usually produces renal failure. Sodium dodecyl sulphate polyacrylamide gel electrophoresis and Western blot using antibodies to IgG and IgA from dogs were carried out in the urine of 22 dogs with leishmaniasis diagnosed by ELISA and confirmed by PCR, and 20 healthy dogs. The results were compared to renal function laboratory tests and to those from a histopathological study of the kidneys from sick animals that died naturally or were euthanized. Five different bands with molecular weights ranging from 10 to 110 kDa were obtained from the electrophoresis of the urine of healthy dogs. 33.5% of total proteins corresponded to low molecular weight proteins and the other proteins had middle and high molecular weights. However, in the group with leishmaniasis, a maximum of 11 different bands with molecular weights ranging from 10 kDa to 150 kDa were displayed in the electrophoresis of the urine. The urine electrophoretic pattern in the sick dogs was classified as mixed (proteins with high and low molecular weights) because low molecular weight proteins made up 57.9% and the rest of the proteins had middle and high molecular weights. In Western blot, none of the healthy dogs showed excretion of IgG and/or IgA, whereas IgG and IgA were detected in the Western blot of urine of 68% and 55% respectively of dogs with leishmaniasis. The results obtained in the leishmaniasis group agreed with glomerular and tubular damage, which were confirmed by the histopathological findings. leishmaniasis / proteinuria / dog / SDS-PAGE / Western blot

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Section: Discussionsupporting

confidence: 88%

SDS-PAGE and Western blot of urinary proteins in dogs with leishmaniasis

et al. 2003

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“…In visceral leishmaniasis, intraocular inflammation may result from the intense presence of leukocytes and Leishmania amastigote-like forms as described for the skin (MOZOS et al, 1999) or from the immune-mediated response (type III hypersensitivity) triggered by Leishmania antigens and by specific and nonspecific immunoglobulin deposits as observed for the glomerular filtration barrier (SARTORI et al, 1987;NIETO et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Histopathological findings and detection of parasites in the eyes of dogs infected naturally with Leishmania chagasi

et al. 2010

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“…Reticular cells of lymph nodes and spleen and skin fibroblasts were also highly infected. Consequences of this infection included chronic dermatitis, orchitis, lymphadenopathy, and hepatosplenomegaly, which are well described for the main host of L. infantum, domestic dogs (Tryphonas et al, 1979;Nieto et al, 1992;Koutinas et al, 1993;Costa et al, 2003;Diniz et al, 2005;Rallis et al, 2005), and in one wild canid, a golden jackal (Hervas et al, 1996). Chronic lesions in other organs that would normally result in severe chronic immune-mediated glomerular nephritis, as described by Costa et al (2003), were not present in this case.…”

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confidence: 52%

“…Chronic lesions in other organs that would normally result in severe chronic immune-mediated glomerular nephritis, as described by Costa et al (2003), were not present in this case. Kidney insufficiency is the most common cause of death resulting from leishmaniosis in dogs (Nieto et al, 1992). The gray wolf presented in this study died from heart insufficiency, which is the probable result of chronic wasting and malnutrition, characteristic symptoms of leishmaniosis (Robinson and Maxie, 1993).…”

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confidence: 68%

A Case of Visceral Leishmaniosis in a Gray Wolf (Canis lupus) from Croatia

Beck

Kusak

et al. 2008

Journal of Wildlife Diseases

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ABSTRACT:The southern habitats of Croatia's gray wolf (Canis lupus) population are found in central and southern parts of Dalmatia. This region is recognized as an endemic region for canine visceral leishmaniosis, caused by Leishmania infantum. In November 2003, a 4-yr-old male gray wolf was found dead in the northwestern border of this endemic region. Pathologic and parasitologic analysis, confirmed by polymerase chain reaction, indicated that lesions associated with infection by Leishmania infantum are, in this case, typical for visceral leshmaniosis commonly described in dogs. Review of the literature suggests that this is the first reported case of gray wolf death due to lesions caused by L. infantum.

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Pathological changes in kidneys of dogs with natural Leishmania infection

Cited by 81 publications

References 13 publications

SDS-PAGE and Western blot of urinary proteins in dogs with leishmaniasis

SDS-PAGE and Western blot of urinary proteins in dogs with leishmaniasis

Histopathological findings and detection of parasites in the eyes of dogs infected naturally with Leishmania chagasi

A Case of Visceral Leishmaniosis in a Gray Wolf (Canis lupus) from Croatia

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