Pathologic Dynamics of Human Hair Loss

Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation

“…Increased hair shedding (or telogen effluvium) is thought to occur due to post-partum hormonal changes (Lynfield 1960;Schiff and Kern 1963;Gizlenti and Ekmekci 2013) or stress (Kligman 1961). Our findings that Prl promotes HF quiescence by directly regulating bulge SC activity support a previously hypothesized role for Prl during post-partum hair shedding (Randall 2007).…”

Intermittent Chronic Telogen Effluvium

“…Kligman [2] underlined that hair shedding begins after 3 months from the causative stress [3]. This is apparent in our case, especially at the very onset in April after the quarrels of January and March 2104; when shedding peaked in December 2014 after the patient found out that wife was cheating on him; in December 2015 after the legal separation obtained in July, and in July 2016 after his problems with his new girlfriend in April (Fig.…”

Telogen Effluvium due to Recombinant Interferon α-2b

“…Although in our 5 patients the rise in the body temper ature after injections did not usually exceed 38 °C, a rela tionship between tclogcn effluvium and IFN-induced fever is a further possibility [1,2]. In our patients no relationships were found between the dosages and time of onset or sever ity of hair loss.…”