Pathogenicity of a GI-22 genotype infectious bronchitis virus isolated in China and protection against it afforded by GI-19 vaccine

Zhao, Ye; Xie, Deqiong; Zhang, Keran; Cheng, Jinlong; Xu, Gang; Zhang, Guozhong

doi:10.1016/j.virusres.2019.05.006

Cited by 11 publications

(9 citation statements)

References 25 publications

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“…The GI-19-type strains could be involved in nephritis and are referred to as the “nephro-pathogenic strains.” Hence, they may not cause significant respiratory lesions ( Zhao et al, 2019 ). Previous studies have reported kidney damage due to the replication mechanism of the monocytes in the chickens infected with QX-type IBVs ( Li et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…IBV can infect chickens of all ages, causing respiratory symptoms, reduced feeding efficiency, and declined egg production and quality ( de Wit et al, 2011 ). This infection mostly affects the respiratory and genitourinary systems; when coinfected with other viruses and bacteria, the mortality can increase up to 60% ( Zhao et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Insights on genetic characterization and pathogenesis of a GI-19 (QX-like) infectious bronchitis virus isolated in China

Yan¹,

Yang²,

Huang³

et al. 2023

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Insights on genetic characterization and pathogenesis of a GI-19 (QX-like) infectious bronchitis virus isolated in China

Yan¹,

Yang²,

Huang³

et al. 2023

Poultry Science

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“…All chickens in the GDTS13-infection groups exhibited previously described clinical manifestations of IBV [17,25,26], including lethargy, feather ruffling, neck shrinkage, head shaking, sneezing, and diarrhea. GDTS13 virus replicated in the trachea, lung, kidney, and glandular stomach tissues from days 3 to 9 postinfection, whereas the virus was only detected in the liver tissue from days 3 to 5 postinfection.…”

Section: Evaluation Of the Pathogenicity Of Strain Gdts13 In Spf Chicmentioning

confidence: 95%

Phylogenetic analysis of infectious bronchitis virus circulating in southern China in 2016–2017 and evaluation of an attenuated strain as a vaccine candidate

et al. 2020

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Avian infectious bronchitis (IB) is a highly contagious viral respiratory disease, caused by infectious bronchitis virus (IBV), that poses an important economic threat to the poultry industry. In recent years, genotypes GI-7, GI-13, and GI-19 have been the most prevalent IBV strains in China. However, in this study, we found that most IBV strains from southern China in 2016-2017 belonged to genotype GVI-1. This genotype, for which there is no vaccine, has been reported sporadically in the region. The GDTS13 strain, which caused severe IB outbreaks on the farms where it was isolated, was evaluated as a candidate vaccine strain. GDTS13 was serially passaged in specific-pathogen-free embryonated chicken eggs for 100 generations to produce GDTS13-F100. Safety testing indicated that GDTS13-F100 had no pathogenic effect on chickens. Additionally, GDTS13-F100 showed an excellent protective effect against GDTS13, with no clinical signs or virus shedding observed in immunized chickens challenged with the parent strain. These findings indicate that GVI-1 has become the most prevalent IBV genotype in southern China and that GDTS13-F100 may serve as an attenuated vaccine to protect against infection with this genotype.

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“…The infected chickens develop cystic oviducts, leading to false layer syndrome with distinctly low peak egg production [ 86 , 87 , 88 , 89 ]. Infection with IBV in laying hens can negatively influence egg production with poor-quality eggs [ 90 , 91 , 92 ]. Several IBV strains can infect the nervous system of chickens [ 93 ].…”

Section: Multiple System Disease Caused By Avian Infectious Bronchiti...mentioning

confidence: 99%

Key Aspects of Coronavirus Avian Infectious Bronchitis Virus

Zhao

Zhang

2023

Pathogens

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Infectious bronchitis virus (IBV) is an enveloped and positive-sense single-stranded RNA virus. IBV was the first coronavirus to be discovered and predominantly causes respiratory disease in commercial poultry worldwide. This review summarizes several important aspects of IBV, including epidemiology, genetic diversity, antigenic diversity, and multiple system disease caused by IBV as well as vaccination and antiviral strategies. Understanding these areas will provide insight into the mechanism of pathogenicity and immunoprotection of IBV and may improve prevention and control strategies for the disease.

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Pathogenicity of a GI-22 genotype infectious bronchitis virus isolated in China and protection against it afforded by GI-19 vaccine

Cited by 11 publications

References 25 publications

Insights on genetic characterization and pathogenesis of a GI-19 (QX-like) infectious bronchitis virus isolated in China

Insights on genetic characterization and pathogenesis of a GI-19 (QX-like) infectious bronchitis virus isolated in China

Phylogenetic analysis of infectious bronchitis virus circulating in southern China in 2016–2017 and evaluation of an attenuated strain as a vaccine candidate

Key Aspects of Coronavirus Avian Infectious Bronchitis Virus

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