Pathogenesis of Severe Neutropenia in Patients With Primary Human Herpesvirus 6B Infection

Abstract

Chemokines may play an important role in the pathogenesis of severe neutropenia in patients with primary HHV-6B infection.

HHV‐6 in liver transplantation: A literature review

“…Myelosuppression has been attributed to HHV‐6 reactivation . In a report of four liver transplant recipients, HHV‐6 reactivation occurred a median of 50 days post‐transplant.…”

“…Myelosuppression has been attributed to HHV-6 reactivation. [43][44][45] In a report of four liver transplant recipients, HHV-6 reactivation occurred a median of 50 days post-transplant. Severe cytopenia was observed in all patients and leucopenia was the most commonly effected bone marrow lineage.…”

Evaluation of Roseola Infantum Cases in Terms of Demographic Properties and Laboratory Values

“…HHV-6 may suppress all bone marrow cell lines (13,14). As a result, neutropenia may first develop, followed by thrombocytopenia (10,11,33). During the first few days of fever in patients with roseola infantum, the mean leucocyte count is around 8-9.0 x 10 9 /L, with a neutrophil dominance.…”

“…Although HHV-6 is a potent stimulator of TNF-α and IL-1β in peripheral blood mononuclear cell cultures, HHV-6 has no effect on IL-6 synthesis. This may be the reason why the CRP level does not increase as an acute phase reactant despite the presence of fever during HHV-6 infection (10). Transient neutropenia has also been reported in primary HHV-6 infection (10,11).…”

“…This may be the reason why the CRP level does not increase as an acute phase reactant despite the presence of fever during HHV-6 infection (10). Transient neutropenia has also been reported in primary HHV-6 infection (10,11). In addition to the inability to synthesize IL-6, which stimulates neutrophil production during primary HHV-6 infection, the suppression of bone marrow progenitor cells may also be responsible for transient neutropenia (12)(13)(14).…”