Abstract:A naturally occurring feline thymic lymphosarcoma (T17) provided the unique observation of a T-cell antigen receptor 13-chain gene (v-Icr) transduced by a retrovirus. The primary tumor contained three classes of feline leukemia virus (FeLV) provirus, which have now been characterized in more detail as (i) v-tcr-containing recombinant proviruses, (ii) v-myc-containing recombinant proviruses, and (iii) apparently full-length helper FeLV proviruses. The two transductions appear to have been independent events, wi… Show more
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