1948
DOI: 10.1001/archderm.1948.01520170077010
|View full text |Cite
|
Sign up to set email alerts
|

Pathogenesis of Benign Tumors of Cutaneous Appendages and of Basal Cell Epithelioma

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

3
25
0

Year Published

1949
1949
2008
2008

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 118 publications
(28 citation statements)
references
References 56 publications
3
25
0
Order By: Relevance
“…Nearly all human BCCs show elevated Hh pathway activity, and several animal models support the notion that uncontrolled Hh signaling is sufficient to drive BCC- or BCC-like tumorigenesis in mice2. The morphological similarity between early superficial BCCs and hair germs was first noted over 70 years ago4,5, suggesting the possibility that canonical Wnt signaling is involved in pathological responses to deregulated Hh signaling in skin. Although some prior studies have identified coordinate changes in the Hh and canonical Wnt pathways in BCCs and other neoplasms1319, direct evidence establishing the functional significance of Wnt signaling in Hh pathway-driven pathology in vivo is lacking.…”
mentioning
confidence: 91%
See 1 more Smart Citation
“…Nearly all human BCCs show elevated Hh pathway activity, and several animal models support the notion that uncontrolled Hh signaling is sufficient to drive BCC- or BCC-like tumorigenesis in mice2. The morphological similarity between early superficial BCCs and hair germs was first noted over 70 years ago4,5, suggesting the possibility that canonical Wnt signaling is involved in pathological responses to deregulated Hh signaling in skin. Although some prior studies have identified coordinate changes in the Hh and canonical Wnt pathways in BCCs and other neoplasms1319, direct evidence establishing the functional significance of Wnt signaling in Hh pathway-driven pathology in vivo is lacking.…”
mentioning
confidence: 91%
“…Intriguingly, superficial BCCs arise as de novo epithelial buds resembling embryonic hair germs4–6, collections of epidermal cells whose development is regulated by canonical Wnt/β-catenin signaling7,8. Similar to embryonic hair germs, human BCC buds showed increased levels of cytoplasmic and nuclear β-catenin, and expressed early hair follicle lineage markers.…”
mentioning
confidence: 99%
“…1,2 Various tissues have been suggested as a possible site of the origin for hidradenoma papilliferum, [3][4][5][6][7][8][9] among which the anogenital mammary-like glands seem to be the most likely one. The neoplasm has distinct histopathological features previously documented in detail.…”
mentioning
confidence: 99%
“…It is difficult to decide histologically, as there is a gradation from trichofoUiculoma to trichoepitheUoma, and then from trichoepithelioma to basal ceU carcinoma with hair foUicle differentiation. This aspect has been weU dealt with by Lever (1948) and by Kligman and Pinkus. Duperrat and Mascaro (1965) have also recently pubUshed a discussion and classification of hair foUicle tumours.…”
mentioning
confidence: 98%