Pathogenesis of Benign Tumors of Cutaneous Appendages and of Basal Cell Epithelioma

Lever, Walter F.

doi:10.1001/archderm.1948.01520170107011

Cited by 46 publications

(14 citation statements)

References 24 publications

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“…These immature neoplastic cells [19] which do not yet show a tendency to kera- -=No positive cells; ± = less than in normal epidermis; + = a s many as in normal epidermis; + + =more than in normal epidermis. tinization seem to have scarcely any affinity to LCs.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Study of Langerhans Cells in Skin Tumors

Sudo¹,

Saito²,

Morohashi³

1987

Dermatology

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The behavior of Langerhans cells in skin tumors was investigated by immunohistochemical techniques using OKT6. OKT6-positive cells were numerous in squamous cell carcinomas, seborrheic keratoses and keratoacanthomas. They were rare in basal cell carcinomas, Bowen’s disease, eccrine poromas, extramammary Paget’s disease and warts. In solar keratosis, the number of OKT6-positive cells was almost equal or slightly larger compared to the normal epidermis. These results indicate that the density of Langerhans cells may not correlate with the degree of malignancy but, to a certain extent, with the nature of the membrane of tumor cells occurring e.g. during keratinization.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical Study of Langerhans Cells in Skin Tumors

Sudo¹,

Saito²,

Morohashi³

1987

Dermatology

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“…The main controversy concerns the microscopic features, which vary from well to poorly differentiated and sometimes undifferentiated varieties. When patients with numerous sebaceous adenomas and other neoplasms with sebaceous differentiation have an associated internal malignancy, the clinical condition is known as Muir-Torre syndrome 7,8 . However, in our study, tumors with sebaceous differentiation did not contribute to a significant proportion, so such association was not observed.…”

Section: Tumors With Sebaceous Differentiationmentioning

confidence: 99%

“…Most SAT are benign, and local complete surgical excision Original Article | Journal of Gandaki Medical College-Nepal is curative. However, diagnosing some of these tumors has important implications, as they might be markers for syndromes associated with internal malignancies, such as trichelemmomas in cowden disease and sebaceous tumors in Muir-Torre syndrome 7,8 . A malignant counterpart of almost every SAT has been described.…”

Section: Introductionmentioning

confidence: 99%

Tumors with Pilosebaceous Differentiation: A Five Year Retrospective Study at BPKIHS

Paudyal

Pradhan

Pokharel

et al. 2018

J. Gandaki Med. Coll. Nepal

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Background: Skin appendageal tumors (SAT) are a large and diverse group of tumors that are commonly classified according to their state of appendageal differentiation: Follicular, sebaceous, eccrine and apocrine. Most adnexal neoplasms are uncommonly encountered in routine practice, and pathologists can easily recognise frequently encountered tumours. In this study, the histological features of important benign and malignant tumors of pilosebaceous origin were reviewed considering its morphologic types, subtypes, age, sex and anatomic site.

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“…Section from lesion revealing cystic space containing papillary invaginations of epithelial cells lining dense fibrous stalks reminiscent of syringocystadenoma papilliferum. X 100. pcarance is not too surprising since such lesions have been considered to be degrees of differentiation toward apocrine and eccrine structures [6,13]. The presence of syringocystadenoma papilliferum does not m itigate against the diagnosis of nevus verrucosus as verrucoid changes of the epidermis were also present beyond the boundaries of the syringocystadenom a papilliferum.…”

Section: Proliferation Of Basal Cells Into Upper Dermis As In Basal Cmentioning

confidence: 99%