Pathogen profiles and molecular epidemiology of respiratory viruses in Japanese inpatients with community-acquired pneumonia

Kurai, Daisuke; Sasaki, Yoshiko; Saraya, Takeshi; Ishii, Haruyuki; Tsukagoshi, Hiroyuki; Kozawa, Kunihisa; Ryo, Akihide; Ishioka, Taisei; Kuroda, Makoto; Oishi, Kazunori; Takizawa, Hajime; Kimura, Hirokazu

doi:10.1016/j.resinv.2016.01.001

Cited by 11 publications

(11 citation statements)

References 48 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, it was shown that an infection with Pseudomonas aeruginosa in primary bronchial epithelia cells could aggravate cells' inflammatory response to RV infections [47]. However, there may be a bidirectional influence, as RV infections also seem to promote secondary bacterial infections [2,48], which may be associated with the disruption of the epithelial barrier of the respiratory tract [49]. Thus, the compound effect of having multiple infections could thus enhance the rate of illness and its severity.…”

Section: Discussionmentioning

confidence: 99%

Human Rhinoviruses in Adult Patients in a Tertiary Care Hospital in Germany: Molecular Epidemiology and Clinical Significance

Golke

Hönemann

Bergs

et al. 2021

Viruses

View full text Add to dashboard Cite

Rhinoviruses (RVs) constitute a substantial public health burden. To evaluate their abundance and genetic diversity in adult patients, RV RNA in respiratory samples was assessed using real-time RT-PCR and the partial nucleic acid sequencing of viral genomes. Additionally, clinical data were retrieved from patient charts to determine the clinical significance of adult RV infections. In total, the respiratory specimens of 284 adult patients (18–90 yrs), collected from 2013 to 2017, were analyzed. Infections occurred throughout the entire year, with peaks occurring in fall and winter, and showed a remarkably high intra- and interseasonal diversity of RV genotypes. RV species were detected in the following ratios: 60.9% RV-A 173, 12.7% RV-B, and 26.4% RV-C. No correlations between RV species and underlying comorbidities such as asthma (p = 0.167), COPD (p = 0.312) or immunosuppression (p = 0.824) were found. However, 21.1% of the patients had co-infections with other pathogens, which were associated with a longer hospital stay (p = 0.024), LRTI (p < 0.001), and pneumonia (p = 0.01). Taken together, this study shows a pronounced genetic diversity of RV in adults and underlines the important role of co-infections. No correlation of specific RV species with a particular clinical presentation could be deduced.

show abstract

Section: Discussionmentioning

confidence: 99%

Human Rhinoviruses in Adult Patients in a Tertiary Care Hospital in Germany: Molecular Epidemiology and Clinical Significance

Golke

Hönemann

Bergs

et al. 2021

Viruses

View full text Add to dashboard Cite

show abstract

“…Other respiratory viruses such as influenza viruses, HPIV, and HRV have been reported to cause lower respiratory symptoms and/or community-acquired pneumonia in adults [8] Recently, we reported the prevalence of viral infections in adult asthma attack patients conducted in the same period of this study that the frequency of HRV and RSV infections seemed to be high in autumn, while HMPV was likely to occur in spring, and influenza virus infections were most common in Table 3 Comparison of the clinical findings between IPF and non-IPF ILDs cases. winter and spring [9].…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of respiratory virus detection in patients with acute exacerbation of interstitial lung diseases

Saraya

Kimura

Kurai

et al. 2018

Respiratory Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this study, Logistic regression analysis showed that the repeated infection (OR=3.315, P=0.005), multi-resistant bacterial infection (OR=1.915, P=0.008) and D-D (OR=1.936, P=0.009) were independent risk factors for SCAP (P<0.05). This is because Gram-negative bacteria dominate in the infectious bacteria of SCAP, and Pseudomonas aeruginosa is the most common, followed by Klebsiella pneumoniae , Staphylococcus aureus and Staphylococcus epidermidis ( 15 ). With the repeated infection, changes in pathogenic bacteria and increased bacterial resistance in patients, multi-resistant bacterial infection will be caused.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia

Duan

Zhang

2018

Oncol Lett

View full text Add to dashboard Cite

The risk factors and coping strategies of severe community-acquired pneumonia (SCAP) in chemotherapy induction period of acute leukemia were investigated. Eighty-six patients with CAP in chemotherapy induction period of acute leukemia in Dezhou Hospital from March 2014 to February 2017 were selected and divided into observation group (SCAP group, n=45) and control group (non-SCAP group, n=41) according to the acute physiology and chronic health evolution II (APACHE II) score. The blood, sputum, nasopharyngeal secretion and pleural effusion samples were collected from patients in both groups, and the samples were detected for pathogens, followed by the analysis of relevant factors. The dynamic changes in the sequential organ failure assessment (SOFA) score, procalcitonin (PCT), D-dimer (D-D) and C-reactive protein (CRP) levels in patients were observed before and after the corresponding treatment strategies were taken. The total distribution ratio of pathogens from high to low in the two groups was as follows: bacterium, virus, fungus, mycoplasma and chlamydia trachomatis; there was no significant difference between the two groups (P>0.05). Logistic regression analysis showed that the repeated infection (OR=3.315, P=0.005), multi-resistant bacterial infection (OR=1.915, P=0.008) and D-D (OR=1.936, P=0.009) were independent risk factors for SCAP (P<0.05). After different coping strategies were taken, the SOFA score, PCT, D-D and CRP levels in the two groups were significantly decreased, and they were obviously higher in observation group than those in control group (P<0.05). Repeated infection, D-D level and multi-resistant bacterial infection are the risk factors affecting the SCAP in chemotherapy induction period of acute leukemia. The coping strategies can effectively relieve the patient's condition, reduce the severity of disease and improve the survival rate of patients.

show abstract

Pathogen profiles and molecular epidemiology of respiratory viruses in Japanese inpatients with community-acquired pneumonia

Abstract: Prevalence of respiratory virus infection in CAP inpatients was 22.3%. The detected viruses display high genetic divergence and correlate with increased respiratory failure.

Cited by 11 publications

References 48 publications

Human Rhinoviruses in Adult Patients in a Tertiary Care Hospital in Germany: Molecular Epidemiology and Clinical Significance

Human Rhinoviruses in Adult Patients in a Tertiary Care Hospital in Germany: Molecular Epidemiology and Clinical Significance

Clinical significance of respiratory virus detection in patients with acute exacerbation of interstitial lung diseases

Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia

Contact Info

Product

Resources

About