Paternal age related schizophrenia and cardiac autonomic regulation profiles

Antonius, Daniel; Kimhy, David; Harkavy‐Friedman, Jill; Crystal, Sarah; Goetz, Ray; Malaspina, Dolores

doi:10.1016/j.schres.2010.10.007

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…Overwhelming evidence of reduced HRV in patients with schizophrenia has accumulated [9] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] . This was described in the acute [9] , [50] , [58] , [59] , [60] , [61] and chronic states [57] , [62] .…”

Section: Discussionmentioning

confidence: 99%

The Phrenic Component of Acute Schizophrenia – A Name and Its Physiological Reality

et al. 2012

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Decreased heart rate variability (HRV) was shown for unmedicated patients with schizophrenia and their first-degree relatives, implying genetic associations. This is known to be an important risk factor for increased cardiac mortality in other diseases. The interaction of cardio-respiratory function and respiratory physiology has never been investigated in the disease although it might be closely related to the pattern of autonomic dysfunction. We hypothesized that increased breathing rates and reduced cardio-respiratory coupling in patients with acute schizophrenia would be associated with low vagal function. We assessed variability of breathing rates and depth, HRV and cardio-respiratory coupling in patients, their first-degree relatives and controls at rest. Control subjects were investigated a second time by means of a stress task to identify stress-related changes of cardio-respiratory function. A total of 73 subjects were investigated, consisting of 23 unmedicated patients, 20 healthy, first-degree relatives and 30 control subjects matched for age, gender, smoking and physical fitness. The LifeShirt®, a multi-function ambulatory device, was used for data recording (30 minutes). Patients breathe significantly faster (p<.001) and shallower (p<.001) than controls most pronouncedly during exhalation. Patients' breathing is characterized by a significantly increased amount of middle- (p<.001), high- (p<.001), and very high frequency fluctuations (p<.001). These measures correlated positively with positive symptoms as assessed by the PANSS scale (e.g., middle frequency: r = 521; p<.01). Cardio-respiratory coupling was reduced in patients only, while HRV was decreased in patients and healthy relatives in comparison to controls. Respiratory alterations might reflect arousal in acutely ill patients, which is supported by comparable physiological changes in healthy subjects during stress. Future research needs to further investigate these findings with respect to their physiological consequences for patients. These results are invaluable for researchers studying changes of biological signals prone to the influence of breathing rate and rhythm (e.g., functional imaging).

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Section: Discussionmentioning

confidence: 99%

The Phrenic Component of Acute Schizophrenia – A Name and Its Physiological Reality

et al. 2012

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“…Antonius et al (30) reported that paternal age-related schizophrenia (PARS), a distinct subgroup of schizophrenia, was associated with abnormal cardiac autonomic regulation, as evidenced by a significantly smaller sleep-related rise in HRV spectral power compared to the non-PARS and normal control groups. These findings suggest that HRV may be associated with a specific subgroup of schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Relationship between heart rate variability and the severity of psychotic symptoms in schizophrenia

Kim

Ann

Lee

2011

Acta Neuropsychiatr.

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Kim J-H, Ann J-H, Lee J. Relationship between heart rate variability and the severity of psychotic symptoms in schizophrenia.Objective: The relationship between autonomic neurocardiac function and schizophrenia remains elusive. This study investigated the relationship between the heart rate variability (HRV) parameters and the severity of psychotic symptoms in schizophrenic patients.Methods: Twenty-one patients receiving risperidone monotherapy and 21 matched normal control subjects were evaluated for HRV analysis. The severity of schizophrenic symptoms was assessed using the Positive and Negative Syndrome Scale (PANSS) and a five-factor model of the PANSS was used.Results: The value of the ratio of low-to-high frequency spectral power was significantly higher in the patient group. The patient group also showed a significantly lower value of approximate entropy. After controlling the dosage of risperidone, the PANSS total score had significant negative correlations with the standard deviation of all RR intervals (SDNN) and the square root of the mean squared differences of successive normal sinus intervals (RMSSD). With respect to the PANSS factors, the score of the PANSS cognitive/disorganisation factor had significant negative correlations with SDNN and RMSSD.Conclusion: These results provide some evidence that the severity of psychotic symptoms, especially cognitive/disorganisation symptom dimensions, may be associated with reduced HRV, suggesting a potential involvement of neuroautonomic dysfunction in the pathophysiology of specific symptoms of schizophrenia.

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“…A mixed effects regression model with a random person level intercept and an autoregressive (AR1) covariance structure within individual was used to model ESM-measured AH predicted by ambulatory vagal input, while adjusting for participants' group (inpatient vs outpatient), age, gender, education, family history of mental illness, antipsychotic dosage, along with paternal age. 45 The primary test of interest is the one-degree of freedom t test for the coefficient for vagal input, which represents the momentary change in AH given a 1-unit change in vagal input. Further exploratory analyses were conducted to examine moderators on the vagal input and AH severity relationship.…”

Section: Statistical Analysesmentioning

confidence: 99%

Autonomic Regulation and Auditory Hallucinations in Individuals With Schizophrenia: An Experience Sampling Study

Kimhy

Wall

Hansen

et al. 2017

Schizophrenia Bulletin

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Auditory Hallucinations (AH) cause substantial suffering and dysfunction, yet remain poorly understood and modeled. Previous reports have linked AH to increases in negative emotions, suggesting a role for the autonomic nervous system (ANS) in underlying this link. Employing an Experience Sampling Method (ESM) approach, 40 individuals with schizophrenia completed a 36-hour ambulatory assessment of AH and cardiac autonomic regulation. Participants carried mobile electronic devices that prompted them to report 10 times/d the severity of their momentary AH, along with a Holter monitor that continuously recorded their cardiac autonomic regulation. The clocks of the devices and monitors were synchronized, allowing for high time-resolution temporal linking of the AH and concurrent autonomic data. Power spectral analysis was used to determine the relative vagal (parasympathetic) contribution to autonomic regulation during 5 minutes prior to each experience sample. The participants also completed interview-based measures of AH (SAPS; PSYRATS). The ESM-measured severity of AH was significantly correlated with the overall SAPS-indexed AH severity, along with the PSYRATS-indexed AH frequency, duration, loudness, degree of negative content, and associated distress. A mixed-effect regression model indicated that momentary increases in autonomic arousal, characterized by decreases in vagal input, significantly predicted increases in ESM-measured AH severity. Vagal input averaged over the 36-hour assessment displayed a small but significant inverse correlation with the SAPS-indexed AH. The results provide preliminary support for a link between ANS regulation and AH. The findings also underscore the highly dynamic nature of AH and the need to utilize high time-resolution methodologies to investigate AH.

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Paternal age related schizophrenia and cardiac autonomic regulation profiles

Cited by 6 publications

References 14 publications

The Phrenic Component of Acute Schizophrenia – A Name and Its Physiological Reality

The Phrenic Component of Acute Schizophrenia – A Name and Its Physiological Reality

Relationship between heart rate variability and the severity of psychotic symptoms in schizophrenia

Autonomic Regulation and Auditory Hallucinations in Individuals With Schizophrenia: An Experience Sampling Study

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