Patents on Endophytic Fungi

Gokhale, Mamta; Gupta, Dileep Kumar; Gupta, U. P.; Faraz, R.; Sandhu, Sardul Singh

doi:10.2174/1872208311666170215151834

Cited by 20 publications

(12 citation statements)

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“…Gokhale et al . () have enlisted several patents granted on different aspects of endophytic fungi. The commercial application of endophytic microbes for plant growth promotion and natural products is not as common as PGPR or mycorrhizae due to a range of scientific and technical challenges especially in formulations (Schönwandt et al .…”

Section: Resultsmentioning

confidence: 99%

Induction of abiotic stress tolerance in plants by endophytic microbes

Lata

Chowdhury

Gond

et al. 2018

Lett Appl Microbiol

416

178

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Significance and Impact of the Study: Increasing human populations demand more crop yield for food security while crop production is adversely affected by abiotic stresses like drought, salinity and high temperature. Development of stress tolerance in plants is a strategy to cope with the negative effects of adverse environmental conditions. Endophytes are well recognized for plant growth promotion and production of natural compounds. The property of endophytes to induce stress tolerance in plants can be applied to increase crop yields. With this review, we intend to promote application of endophytes in biotechnology and genetic engineering for the development of stress-tolerant plants. AbstractEndophytes are micro-organisms including bacteria and fungi that survive within healthy plant tissues and promote plant growth under stress. This review focuses on the potential of endophytic microbes that induce abiotic stress tolerance in plants. How endophytes promote plant growth under stressful conditions, like drought and heat, high salinity and poor nutrient availability will be discussed. The molecular mechanisms for increasing stress tolerance in plants by endophytes include induction of plant stress genes as well as biomolecules like reactive oxygen species scavengers. This review may help in the development of biotechnological applications of endophytic microbes in plant growth promotion and crop improvement under abiotic stress conditions.

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Section: Resultsmentioning

confidence: 99%

Induction of abiotic stress tolerance in plants by endophytic microbes

Lata

Chowdhury

Gond

et al. 2018

Lett Appl Microbiol

416

178

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“…Endophytic fungi have a higher potential to produce a wide variety of bioactive molecules that belong to various structural classes (such as alkaloids, peptides, steroids, terpenoids, phenols, quinones, and flavonoids). These chemical variety of fungi metabolites is associated with the inhibition of a wide variety of pathogenic microorganisms [ 7 - 9 , 12 , 13 ].…”

Section: Resultsmentioning

confidence: 99%

“…Endophyte research has stimulated the interest of the scientific community, as these microorganisms represent an important genetic source with the ability to produce metabolites with diverse biotechnological applications [ 7 - 9 ]. Several studies have shown that the colonization and distribution of the endophytic population in plant tissues are regulated by different properties such as environmental factors, microorganism-plant interactions and endophyte community interactions [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Cultivable Endophytic Fungi Associated with Hancornia Speciosa Gomes Bark

Chagas¹,

Santos²,

Silva³

et al. 2017

TOMICROJ

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Introduction:In this study, we evaluated the antimicrobial potential of cultivable endophytic fungi associated with Hancornia speciosa Gomes stem bark.Methods and Materials:Plant samples were collected in rainy (July 2010) and dry (January 2011) seasons. In total, 116 endophytic fungi strains were isolated from 90 fragments (64.4% frequency of colonization). Higher fungi frequency was observed in the rainy season (84.4%). The strains were grouped into 14 species; the most frequent were Phoma cava (13.8%), Colletotrichum gloeosporioides (12.1%), and Lasiodiplodia theobromae (11.2%). Fungal diversity was similar in both the seasons. Among the 116 strains, 39 (33.6%) showed antimicrobial activity in preliminary screening. The ten most active isolates were subjected to semi-solid fermentation using rice or corn as substrates. Methanolic extracts were obtained from each fermentation medium and the minimum inhibitory (MIC) and minimum microbicide concentrations (MMC) were determined.Results:The best antimicrobial results (MIC < 100 µg/mL) were observed for fungi strains grown in rice medium: Aspergillus niger FHS061 against Proteus mirabilis (MIC = 19 µg/mL) and Staphylococcus aureus (MIC = 39 µg/mL). These strains also showed good results when cultivated in corn medium against P. mirabilis (MIC = 78 µg/mL).Conclusion:Thus, the stem bark of H. speciosa harbors diverse endophytic fungi with antimicrobial potential.

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“…During the last 10 years it became apparent that endophytes are capable to produce the same bioactive secondary metabolites as their hosts and therefore there is a tremendous interest of the scientifi c community towards isolation, characterization and exploitation of endophytic fungi from medicinal plants as was judged by the amount of publications and number of patents (Gokhale et al, 2017). …”

Section: Discussionmentioning

confidence: 99%

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Venieraki

Dimou

Katinakis

2017

Hellenic Plant Protection Journal

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SummaryMedicinal plants have been used for thousands of years in folk medicines and still are used for their health benefi ts. In our days medicinal plants are exploited for the isolation of plant-derived drugs as they are very eff ective and have relatively less or no side eff ects. However, the natural resources of medicinal plants are gradually exhausted and access to plant bioactive compounds is challenged by the low levels at which these products accumulate in native medicinal plants. For instance, to meet the market demands of 3 Kg per year of vinca alkaloids, powerful plant-derived anticancer drugs, 1.5x106 Kg dry leaves are required. In this regard, this review aims to highlight the fact that endophytic fungi residing in medicinal plants are capable to biosynthesize pharmacologically active secondary metabolites similar or identical to those produced by their host medicinal plant. Furthermore, the evolutionary origin of the genes involved in these metabolic pathways as well as the approaches designed to enhance the production of these metabolites by the isolated endophytic fungi are also discussed.Additional key words: metabolites from endophytic bacteria and actinomycetes, chemical ecology present in virtually all organs of a given plant host, and some are seed borne. Endophytes often confer considerable benefi ts to the host plant they inhabit, since they can promote the growth of host plants, enhance resistance to biotic and abiotic stresses (Rodriguez et al., 2009; Hardoim et al., 2015), and accumulate bioactive secondary metabolites (Kusari et al., 2012). The ecological role of secondary metabolites produced by endophytes is not clear. However, recent studies have shown that these metabolites are involved in deterrence of herbivory (Pannaccione et al., 2014), protection against fungal (Soliman et al., 2015) or bacterial pathogens (Mousa et al., 2017) and amelioration of plant abiotic stress (Hamayum et al., 2016). Bioactive secondary metabolites derived from medicinal plants are gradually decreasing -Alternative approaches for their productionMedicinal plants, as a rich source of nat-

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Patents on Endophytic Fungi

Abstract: In the last few years, research and inventions regarding the different aspects of endophytic fungi beneficial for host plant as well as for human beings have been carried out, which is supported by the increasing number of patents granted on endophytic fungi.

Cited by 20 publications

References 0 publications

Induction of abiotic stress tolerance in plants by endophytic microbes

Induction of abiotic stress tolerance in plants by endophytic microbes

Antimicrobial Activity of Cultivable Endophytic Fungi Associated with Hancornia Speciosa Gomes Bark

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

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