Patent Foramen Ovale: A Nonfunctional Embryological Remnant or a Potential Cause of Significant Pathology?

Movsowitz, Colin; Podolsky, Leo A.; Meyerowitz, Colin B.; Jacobs, Larry E.; Kotler, Morris N.

doi:10.1016/s0894-7317(14)80346-5

Cited by 79 publications

(34 citation statements)

References 51 publications

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“…Thus, the clinical importance of a PFO still continues to be the subject of debate. 24 Transient right-to-left shunt through a PFO can, indeed, occur even in the presence of normal right-side hemodynamics. 4,14,25 However, this phenomenon becomes especially prominent in the setting of elevated right-side pressures.…”

Section: Discussionmentioning

confidence: 99%

Patent Foramen Ovale Is an Important Predictor of Adverse Outcome in Patients With Major Pulmonary Embolism

et al. 1998

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Background-Right-to-left shunt through a patent foramen ovale is frequently diagnosed by contrast echocardiography and can be particularly prominent in the presence of elevated pressures in the right side of the heart. Its prognostic significance in patients with pulmonary thromboembolism, however, is unknown. Methods and Results-The present prospective study included 139 consecutive patients with major pulmonary embolism diagnosed on the basis of clinical, echocardiographic, and cardiac catheterization criteria. All patients underwent contrast echocardiography at presentation. The end points of the study were overall mortality and complicated clinical course during the hospital stay defined as death, cerebral or peripheral arterial thromboembolism, major bleeding, or need for endotracheal intubation or cardiopulmonary resuscitation. Patent foramen ovale was diagnosed in 48 patients (35%). These patients had a death rate of 33% as opposed to 14% in patients with a negative echo-contrast examination (Pϭ.015). Logistic regression analysis demonstrated that the only independent predictors of mortality in the study population were a patent foramen ovale (odds ratio

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Section: Discussionmentioning

confidence: 99%

Patent Foramen Ovale Is an Important Predictor of Adverse Outcome in Patients With Major Pulmonary Embolism

et al. 1998

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“…The pathological consequences of the right-to-left shunt include hypoxemia and paradoxical embolism. Paradoxical embolism through a POF is well documented and its role in the etiology of thromboembolism of obscure origin (cryptogenic thromboembolism) is a matter of great discussions and controversies [20].…”

Section: Case 4 Cia and Thromboembolism Cerebral Thromboembolismmentioning

confidence: 99%

Eventos catastróficos associados ao tratamento da comunicação interatrial tipo ostium secundum: razões para não se subestimar este tipo de cardiopatia congênita

Évora¹,

Ribeiro²,

Vicente³

et al. 2004

Rev Bras Cir Cardiovasc

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Objective: The present article was motivated by the frustrating experiences with four patients who underwent surgical treatment of ostium secundum atrial septal defect (ASD-II) and who died in extremely dramatic circumstances.Method: This is a retrospective study based on clinical data. The bibliographical research included: paradoxical thromboembolism (cerebral, pulmonary or mesenteric), central nervous system vascular malformations and anomalous vena cava connections. This research was based on possible events, unexpected and catastrophic, that could have directly caused the patients' deaths.Results: All patients were female. The operations were performed under cardiopulmonary bypasses with less than 20 minutes of aortic cross-clamping. The causes of death were: non-occlusive intestinal ischemia, rupture of a cerebral aneurysm of the anterior communicating artery, cor pulmonale associated with pulmonary arterial hypertension and thromboembolism and probable cerebral thromboembolism in a child that needed to be reoperated to correct anomalous inferior vena cava drainage into the left atrium.Conclusion: Even being technically easy to treat, death due to atrial septal defects in extremely dramatic circumstances is possible, so "Do not underestimate atrial septal defects in congenital heart surgery". Descriptors:Heart septal defects, atrial, surgery, complications. Heart defects, congenital, surgery, complications. Extracorporeal circulation.Eventos catastróficos associados ao tratamento da comunicação interatrial tipo ostium secundum: razões para não se subestimar este tipo de cardiopatia congênita Catastrophic events associated to the surgical treatment of ostium secundum atrial septal defects. Reasons for not underestimating this type of congenital cardiopathy 392 EVORA, PRB ET AL -Catastrophic events associated to the surgical treatment of ostium secundum atrial septal defects. Reasons for not underestimating this type of congenital cardiopathy Braz

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“…The second reason that these pathways are clinically relevant is that anatomic right-to-left shunts may allow for thrombi to bypass the pulmonary capillary filter. Indeed, a patent foramen ovale and pulmonary arteriovenous malformations are associated with increased risk for neurological sequelae such as migraines, transient ischemic attacks and stroke (Movsowitz et al, 1992;Petty et al, 1997;De Castro et al, 2000;Lamy et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Detection of Intracardiac and Intrapulmonary Shunts at Rest and During Exercise Using Saline Contrast Echocardiography

Lovering¹,

Goodman²

2012

Applied Aspects of Ultrasonography in Humans

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Patent Foramen Ovale: A Nonfunctional Embryological Remnant or a Potential Cause of Significant Pathology?

Cited by 79 publications

References 51 publications

Patent Foramen Ovale Is an Important Predictor of Adverse Outcome in Patients With Major Pulmonary Embolism

Patent Foramen Ovale Is an Important Predictor of Adverse Outcome in Patients With Major Pulmonary Embolism

Eventos catastróficos associados ao tratamento da comunicação interatrial tipo ostium secundum: razões para não se subestimar este tipo de cardiopatia congênita

Detection of Intracardiac and Intrapulmonary Shunts at Rest and During Exercise Using Saline Contrast Echocardiography

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