Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/MyD88/NF-kB pathway and regulation of microbiota

Wu, Jingsong; Gan, Yuxuan; Li, Muxia; Chen, Liping; Liang, Jia-Li; Zhuo, Jian-Yi; Luo, Huijuan; Xu, Nan; Wu, Xue; Wu, Qiong; Lin, Zhi‐Xiu; Su, Zi‐Ren; Liu, Yuhong

doi:10.1016/j.biopha.2020.109883

Cited by 55 publications

(45 citation statements)

References 55 publications

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“…Of scientific and clinical interest, it has been clearly demonstrated that microbiota imbalance can provoke immune alterations and potentiate proinflammatory pathways [ 59 , 60 ]. It has also been reported that gut dysbiosis causes alterations in numerous proinflammatory biomarkers such as TLR4, MDA, MPO, IL-1β or TNF-α [ 65 , 66 , 67 , 68 , 69 , 70 ]. Recent studies further demonstrate that microbiota may regulate the immune system, since microbial changes seem to affect IL-10 production (an anti-inflammatory cytokine) [ 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

Role of Dietary Nutritional Treatment on Hepatic and Intestinal Damage in Transplantation with Steatotic and Non-Steatotic Liver Grafts from Brain Dead Donors

et al. 2021

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Herein, we investigate whether: (1) the administration of glucose or a lipid emulsion is useful in liver transplantation (LT) using steatotic (induced genetically or nutritionally) or non-steatotic livers from donors after brain death (DBDs); and (2) any such benefits are due to reductions in intestinal damage and consequently to gut microbiota preservation. In recipients from DBDs, we show increased hepatic damage and failure in the maintenance of ATP, glycogen, phospholipid and growth factor (HGF, IGF1 and VEGFA) levels, compared to recipients from non-DBDs. In recipients of non-steatotic grafts from DBDs, the administration of glucose or lipids did not protect against hepatic damage. This was associated with unchanged ATP, glycogen, phospholipid and growth factor levels. However, the administration of lipids in steatotic grafts from DBDs protected against damage and ATP and glycogen drop and increased phospholipid levels. This was associated with increases in growth factors. In all recipients from DBDs, intestinal inflammation and damage (evaluated by LPS, vascular permeability, mucosal damage, TLR4, TNF, IL1, IL-10, MPO, MDA and edema formation) was not shown. In such cases, potential changes in gut microbiota would not be relevant since neither inflammation nor damage was evidenced in the intestine following LT in any of the groups evaluated. In conclusion, lipid treatment is the preferable nutritional support to protect against hepatic damage in steatotic LT from DBDs; the benefits were independent of alterations in the recipient intestine.

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Section: Discussionmentioning

confidence: 99%

Role of Dietary Nutritional Treatment on Hepatic and Intestinal Damage in Transplantation with Steatotic and Non-Steatotic Liver Grafts from Brain Dead Donors

et al. 2021

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“…It has been shown that the regulation of TNF-a biosynthesis induced by LPS is redox sensitive and requires the participation of the glutathione mediated signaling pathway. In the presence of glutathione, it can activate the activity of PGE synthase-1 (mPGES-1) to produce PGE2 (Wrotek et al, 2015).…”

Section: Materials Basis Of Fevermentioning

confidence: 99%

“…Therefore, the effective component of Pogostemon Herba to improve intestinal function may be water-soluble. Wu et al (2020) established a rat model of intestinal mucositis via intraperitoneal injection of 5fluorouracil, and intragastrically administrated Patchouli alcohol (PA) (10, 20, and 40 mg/kg) to evaluate the effect of PA on intestinal mucositis. The results showed that PA could effectively improve diarrhea in intestinal mucositis rats, (Liu et al, 2019) III preliminary confirming PA efficacy.…”

Section: Single Chinese Herbal Medicine Pogostemon Herbamentioning

confidence: 99%

Research Progress on Main Symptoms of Novel Coronavirus Pneumonia Improved by Traditional Chinese Medicine

Luo

Liu

et al. 2020

Front. Pharmacol.

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Novel coronavirus (COVID-19) pneumonia has become a major threat to worldwide public health, having rapidly spread to more than 180 countries and infecting over 1.6 billion people. Fever, cough, and fatigue are the most common initial symptoms of COVID-19, while some patients experience diarrhea rather than fever in the early stage. Many herbal medicine and Chinese patent medicine can significantly improve these symptoms, cure the patients experiencing a mild 22form of the illness, reduce the rate of transition from mild to severe disease, and reduce mortality. Therefore, this paper summarizes the physiopathological mechanisms of fever, cough, fatigue and diarrhea, and introduces Chinese herbal medicines (Ephedrae Herba, Gypsum Fibrosum, Glycyrrhizae Radix et Rhizoma, Asteris Radix et Rhizoma, Ginseng Radix et Rhizoma, Codonopsis Radix, Atractylodis Rhizoma, etc.) and Chinese patent medicines (Shuang-huang-lian, Ma-xinggan-shi-tang, etc.) with their corresponding therapeutic effects. Emphasis was placed on their material basis, mechanism of action, and clinical research. Most of these medicines possess the pharmacological activities of anti-inflammatory, antioxidant, antiviral, and immunity-enhancement, and may be promising medicines for the treatment or adjuvant treatment of COVID-19 patients.

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“…Liu et al [18] demonstrated that PA has a protective effect against heat shock-induced injury in a rat intestinal epithelial cell line (IEC-6) through its anti-oxidative properties, as evidenced by downregulated oxidative stress markers (ROS and MDA) and upregulated anti-oxidative enzymes (SOD, CAT and GSH-px) and survival signaling regulators (Nrf2, Keap1 and HO-1). In an animal study, PA administration (10, 20 and 40 mg/kg) prevented 5-fluorouracil (5-FU)-induced intestinal mucositis via suppression of TLR2/MyD88-mediated NF-B pathway activation [23] . Treatment with PA attenuated body weight loss, diarrhea and intestinal mucous tissue injury induced by 5-FU treatment.…”

Section: Health Beneficial Effects Of Pamentioning

confidence: 99%

“…1 ). Diverse health beneficial activities have been documented for PA, including: anti-influenza virus [10] , [11] , [12] , [13] , anti-inflammatory [14] , [15] , [16] , [17] , anti-oxidative [18] , anti-ulcerogenic [19] , [20] , anti-colitis [21] , [22] , anti-mucositis [23] and protective activities against brain and lung injuries [24] , [25] . Most recently, the effects of PA on cancer and metabolic disorders including obesity, fatty liver and gut microbiota have come under investigation [26] , [27] , [28] , [29] .…”

Section: Introductionmentioning

confidence: 99%

Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review

Lee

Smolensky

et al. 2020

International Immunopharmacology

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Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/MyD88/NF-kB pathway and regulation of microbiota

Cited by 55 publications

References 55 publications

Role of Dietary Nutritional Treatment on Hepatic and Intestinal Damage in Transplantation with Steatotic and Non-Steatotic Liver Grafts from Brain Dead Donors

Role of Dietary Nutritional Treatment on Hepatic and Intestinal Damage in Transplantation with Steatotic and Non-Steatotic Liver Grafts from Brain Dead Donors

Research Progress on Main Symptoms of Novel Coronavirus Pneumonia Improved by Traditional Chinese Medicine

Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review

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