Patagonian Berries: Healthy Potential and the Path to Becoming Functional Foods

Fuentes, Lida; Figueroa, Carlos R.; Valdenegro, Mónika; Vinet, Raúl

doi:10.3390/foods8080289

Cited by 25 publications

(32 citation statements)

References 122 publications

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“…Among non-flavonoids there are two subgroups: non-carboxylic phenols and phenolic acids (derived from benzoic acid and cinnamic acid). [31][32][33][34][35] These compounds are not considered to have a nutritional function, nor are they essential for human health, but they can have a significant impact in preventing, delaying the onset, or ameliorating the effects of some diseases. 36 Polyphenols constitute the majority of secondary metabolites in berries.…”

Section: Bioactive Compoundsmentioning

confidence: 99%

“…In maqui, delphinidin-and cyanidin-were the most abundant derivatives identified. 22,34,35,40 The profile and polyphenolic composition of calafate berries was identified by HPLC-MS showing that anthocyanins contribute to the major part of the polyphenolic richness of this fruit. 12 The profile also revealed that most polyphenols are in a conjugated form (glucoside and / or galactoside conjugates)that is, as glycosides, mainly as anthocyanins of the 3-glucoside type.…”

Section: Bioactive Compoundsmentioning

confidence: 99%

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Antioxidant, functional properties and health‐promoting potential of native South American berries: a review

2020

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Nowadays berries are globally recognized to be among the healthiest foods because they contain diverse and abundant bioactive compounds. Among these are phenolic acids, flavonoids, and anthocyanins, which are known to have beneficial health effects. South America, particularly southern Chile, is covered by a diversity of insufficiently studied and underexploited native berry species. In this review we summarize all the available literature on the phenolic composition, antioxidant activity, bioaccessibility, and biological activity of five native South American berries: calafate, maqui, murta, arrayán, and chequén. The potential of these native berries for promoting human health and as source of bioactive substances is remarkable. Bioactive compounds, mainly anthocyanins, and in less abundance flavonoids and phenolic acids, show strong antioxidant effects. Some of these constituents are bioaccessible and bioavailable, and exert anticancer, antimicrobial, and anti-inflammatory activities as well as inhibitory effects against enzymes involved in metabolic syndromes. Given the potential of native South American berries to promote health, more work is still needed to understand fully the potential beneficial effects of the consumption of these berries on human health.

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Section: Bioactive Compoundsmentioning

confidence: 99%

Section: Bioactive Compoundsmentioning

confidence: 99%

Antioxidant, functional properties and health‐promoting potential of native South American berries: a review

2020

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“…As part of the diets, many fruits of native species have been used as a traditional medicine in the South American region [1,2]. The Chilean trees, arrayan [Luma apiculata (DC.)…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Extracts of Two Native Fruits of Chile: Arrayan (Luma apiculata) and Peumo (Cryptocarya alba)

et al. 2020

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Arrayan and peumo fruits are commonly used in the traditional medicine of Chile. In this study, the concentration of the extracts halving the bacterial viability and biofilms formation and disruption of the drug-sensitive and drug-resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa was determined. The chemical composition of extracts was analyzed by high-resolution liquid chromatography coupled with mass spectrometry (U-HPLC/MS). The arrayan extract (Inhibitory concentration IC50 0.35 ± 0.01 mg/mL) was more effective than peumo extract (IC50 0.53 ± 0.02 mg/mL) in the inhibition of S. aureus planktonic cells. Similarly, the arrayan extract was more effective in inhibiting the adhesion (S. aureus IC50 0.23 ± 0.02 mg/mL, P. aeruginosa IC50 0.29 ± 0.02 mg/mL) than peumo extracts (S. aureus IC50 0.47 ± 0.03 mg/mL, P. aeruginosa IC50 0.35 ± 0.01 mg/mL). Both extracts inhibited quorum sensing in a concentration-dependent manner, and the most significant was the autoinducer-2 type communication inhibition by arrayan extract. Both extracts also disrupted preformed biofilm of P. aeruginosa (arrayan IC50 0.56 ± 0.04 mg/mL, peumo IC50 0.59 ± 0.04 mg/mL). However, neither arrayan nor peumo extracts disrupted S. aureus mature biofilm. U-HPLC/MS showed that both fruit extracts mainly possessed quercetin compounds; the peumo fruit extract also contained phenolic acids and phenylpropanoids. Our results suggested that both extracts could be used as natural antimicrobials for some skin and nosocomial infections.

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“…In this context, the consumption of fruits with a high level of antioxidants, especially anthocyanins, has been proposed as a good option to reduce the risk of chronic diseases development (Battino et al 2019;Muceniece et al 2019). Therefore, several studies have recently focused on chemoprotective properties of Chilean native berries, particularly rich in anthocyanins, which have gained quickly the interest of researchers around the world (Cespedes-Acuña et al 2018;Fuentes et al 2019;Mariangel et al 2013;Ramirez et al 2015;Ruiz et al 2013a).…”

Section: Introductionmentioning

confidence: 99%

Anthocyanin-Rich Extracts of Calafate (Berberis microphylla G. Forst.) Fruits Decrease In Vitro Viability and Migration of Human Gastric and Gallbladder Cancer Cell Lines

Calderón-Reyes

Pezoa

Leal

et al. 2020

J Soil Sci Plant Nutr

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Currently, gastric cancer (GC) and gallbladder cancer (GBC) constitute important causes of human deaths related to cancer worldwide. In the last years, several researches are focused on the role of dietary compounds in preventing cancers. The consumption of fruits with high antioxidants, mainly anthocyanins, represents a good option to reduce the risk of chronic human diseases. Calafate (Berberis microphylla G. Forst.) berries, recognized by their remarkable antioxidant properties and high content of anthocyanins, appear as a new alternative to treat degenerative diseases of public interest. The present work was aimed to evaluate the impact of crude and anthocyanin-rich extracts from Calafate fruits on in vitro cell viability and migration capacity of gastric (AGC) and gallbladder (G415) human cancer cell lines, as related with their antioxidant properties. Crude and anthocyanin-rich extracts were obtained from fruits of Calafate grown under field conditions in the south of Chile. Antioxidants, phenols, anthocyanins, and anthocyanidins were determined. In vitro cell viability and migration of AGS and G415 human cancer cell lines at different concentrations of extracts (25-800 μg mL −1) were determined. Anthocyanin-rich extracts of Calafate berries showed comparable antioxidant activity (up to 1200 μg Trolox eq. g −1 DW), slightly lower total phenolic content (12%), but higher total anthocyanin content (25%) compared to the crude extract. The major anthocyanidin molecule detected in both extracts was delphinidin, followed by malvidin, and low concentrations of petunidin, cyanidin, and peonidin. As expected, all of these compounds were detected in higher levels in anthocyanin-rich extracts (up to 2-fold). Noteworthy, our study revealed that Calafate fruit extracts strongly decrease in vitro viability and migration capacity of gastric carcinoma (AGC model) and gallbladder carcinoma (G415 model) human cell lines; however, the anthocyanin-rich extract displayed higher inhibitory effects (up to 70%) compared to crude extracts. These findings allow suggesting that the in vitro antiproliferative potential of Calafate fruit extract is strongly related to the anthocyanin concentration, especially delphinidin.

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Patagonian Berries: Healthy Potential and the Path to Becoming Functional Foods

Cited by 25 publications

References 122 publications

Antioxidant, functional properties and health‐promoting potential of native South American berries: a review

Antioxidant, functional properties and health‐promoting potential of native South American berries: a review

Antimicrobial Activity of Extracts of Two Native Fruits of Chile: Arrayan (Luma apiculata) and Peumo (Cryptocarya alba)

Anthocyanin-Rich Extracts of Calafate (Berberis microphylla G. Forst.) Fruits Decrease In Vitro Viability and Migration of Human Gastric and Gallbladder Cancer Cell Lines

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