Past and Current Progress in the Development of Antiviral/Antimicrobial Polymer Coating towards COVID-19 Prevention: A Review

Nasri, Nazihah; Rusli, Arjulizan; Teramoto, Naozumi; Jaafar, Mariatti; Ishak, Ku Marsilla Ku; Shafiq, Mohd Danial; Hamid, Zuratul Ain Abdul

doi:10.3390/polym13234234

Cited by 14 publications

(6 citation statements)

References 239 publications

(220 reference statements)

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“…There are many naturally occurring materials that are used as antiviral coatings. Chitosan is a common antimicrobial material derived from naturally occurring polymer chitin [ 39 ]. It is effective against human immunodeficiency virus (HIV), hepatitis B virus (HBV), and influenza virus.…”

Section: Current Antiviral Surface Coating Techniquesmentioning

confidence: 99%

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Antiviral Peptides in Antimicrobial Surface Coatings—From Current Techniques to Potential Applications

Jabeen

Biswas

Islam

et al. 2023

Viruses

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The transmission of pathogens through contact with contaminated surfaces is an important route for the spread of infections. The recent outbreak of COVID-19 highlights the necessity to attenuate surface-mediated transmission. Currently, the disinfection and sanitization of surfaces are commonly performed in this regard. However, there are some disadvantages associated with these practices, including the development of antibiotic resistance, viral mutation, etc.; hence, a better strategy is necessary. In recent years, peptides have been studied to be utilized as a potential alternative. They are part of the host immune defense and have many potential in vivo applications in drug delivery, diagnostics, immunomodulation, etc. Additionally, the ability of peptides to interact with different molecules and membrane surfaces of microorganisms has made it possible to exploit them in ex vivo applications such as antimicrobial (antibacterial and antiviral) coatings. Although antibacterial peptide coatings have been studied extensively and proven to be effective, antiviral coatings are a more recent development. Therefore, this study aims to highlight antiviral coating strategies and the current practices and application of antiviral coating materials in personal protective equipment, healthcare devices, and textiles and surfaces in public settings. Here, we have presented a review on potential techniques to incorporate peptides in current surface coating strategies that will serve as a guide for developing cost-effective, sustainable and coherent antiviral surface coatings. We further our discussion to highlight some challenges of using peptides as a surface coating material and to examine future perspectives.

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Section: Current Antiviral Surface Coating Techniquesmentioning

confidence: 99%

“… Classification of current antiviral surface coating materials (adapted with permission from Nasri et al [ 39 ]). …”

Section: Figurementioning

confidence: 99%

Antiviral Peptides in Antimicrobial Surface Coatings—From Current Techniques to Potential Applications

Jabeen

Biswas

Islam

et al. 2023

Viruses

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“…Previous studies have shown a similar relationship between antiviral properties and the material surface roughness and wettability. 66 ■ CONCLUSIONS PP is used in many commonly encountered materials, such as automotive parts, textiles, electrical products, medical equipment, and packaging materials. The recent COVID-19 pandemic has triggered a growing need for antiviral materials; however, imparting antiviral properties to PP has remained technically challenging because of its low polarity and surface energy.…”

Section: ■ Introductionmentioning

confidence: 99%

Polypropylene-Rendered Antiviral by Three-Dimensionally Surface-Grafted Poly(N-benzyl-4-vinylpyridinium bromide)

Hirao,

Takeuchi,

Kawada

et al. 2024

ACS Appl. Mater. Interfaces

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To inhibit viral infection, it is necessary for the surface of polypropylene (PP), a polymer of significant industrial relevance, to possess biocidal properties. However, due to its low surface energy, PP weakly interacts with other organic molecules. The biocidal effects of quaternary ammonium compounds (QACs) have inspired the development of nonwoven PP fibers with surface-bound quaternary ammonium (QA). Despite this advancement, there is limited knowledge regarding the durability of these coatings against scratching and abrasion. It is hypothesized that the durability could be improved if the thickness of the coating layer were controlled and increased. We herein functionalized PP with three-dimensionally surface-grafted poly(N-benzyl-4-vinylpyridinium bromide) (PBVP) by a simple and rapid method involving graft polymerization and benzylation and examined the influence of different factors on the antiviral effect of the resulting plastic by using a plaque assay. The thickness of the PBVP coating, surface roughness, and amount of QACs, which jointly determine biocidal activity, could be controlled by adjusting the duration and intensity of the ultraviolet irradiation used for grafting. The best-performing sample reduced the viral infection titer of an enveloped model virus (bacteriophage ϕ6) by approximately 5 orders of magnitude after 60 min of contact and retained its antiviral activity after surface polishing-simulated scratching and abrasion, which indicated the localization of QACs across the coating interior. Our method may expand the scope of application to resin plates as well as fibers of PP. Given that the developed approach is not limited to PP and may be applied to other low-surface-energy olefinic polymers such as polyethylene and polybutene, our work paves the way for the fabrication of a wide range of biocidal surfaces for use in diverse environments, helping to prevent viral infection.

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“…Most of the reports on polymer gel/disinfectant systems have focused on antibacterial properties. Studies of antiviral activity of such materials are scarce [35,36], most of them dealing with uncross-linked polyelectrolytes. For instance, in Ref.…”

Section: Introductionmentioning

confidence: 99%

Antiseptic Polymer–Surfactant Complexes with Long-Lasting Activity against SARS-CoV-2

et al. 2022

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Antiseptic polymer gel–surfactant complexes were prepared by incorporating the low-molecular-weight cationic disinfectant cetylpyridinium chloride into the oppositely charged, slightly cross-linked polymer matrices. Three types of polymers were used: copolymers of acrylamide and sodium 2-acrylamido-2-methylpropane sulfonate; copolymers of acrylamide and sodium methacrylate; copolymers of vinylpyrrolidone and sodium methacrylate. It was shown that the rate of the release of the cationic disinfectant from the oppositely charged polymer gels could be tuned in a fairly broad range by varying the concentration of the disinfectant, the degree of swelling, and degree of cross-linking of the gel and the content/type of anionic repeat units in the polymer matrix. Polymer–surfactant complexes were demonstrated to reduce SARS-CoV-2 titer by seven orders of magnitude in as little as 5 s. The complexes retained strong virucidal activity against SARS-CoV-2 for at least one week.

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Past and Current Progress in the Development of Antiviral/Antimicrobial Polymer Coating towards COVID-19 Prevention: A Review

Cited by 14 publications

References 239 publications

Antiviral Peptides in Antimicrobial Surface Coatings—From Current Techniques to Potential Applications

Antiviral Peptides in Antimicrobial Surface Coatings—From Current Techniques to Potential Applications

Polypropylene-Rendered Antiviral by Three-Dimensionally Surface-Grafted Poly(N-benzyl-4-vinylpyridinium bromide)

Antiseptic Polymer–Surfactant Complexes with Long-Lasting Activity against SARS-CoV-2

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