2002
DOI: 10.1152/japplphysiol.00621.2001
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Abstract: In this work we studied changes in passive elastic properties of rat soleus muscle fibers subjected to 14 days of hindlimb unloading (HU). For this purpose, we investigated the titin isoform expression in soleus muscles, passive tension-fiber strain relationships of single fibers, and the effects of the thick filament depolymerization on passive tension development. The myosin heavy chain composition was also measured for all fibers studied. Despite a slow-to-fast transformation of the soleus muscles on the ba… Show more

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Cited by 102 publications
(79 citation statements)
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“…9). The discrepancy with the results of Toursel et al (24) could mainly stem from the unloading paradigm and duration, as well as the species and muscle investigated.…”
Section: Passive Tensioncontrasting
confidence: 84%
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“…9). The discrepancy with the results of Toursel et al (24) could mainly stem from the unloading paradigm and duration, as well as the species and muscle investigated.…”
Section: Passive Tensioncontrasting
confidence: 84%
“…For each experiment, passive tension was expressed as a function of fiber strain, evaluated as the ratio of fiber length for a given stretch (mm) divided by fiber length at 76% of initial length (mm) minus one. The ascending limb of the passive tension-fiber strain relationship was analyzed using the equation Y ϭ E ⅐ X 2 , where X is the fiber strain and E (kN/m 2 ) represents complex Young's modulus reflecting the steepness of the curve and thus the stiffness of the fiber (24). Only individual experiments for which this relationship yielded a r 2 of Ն0.98 were included for further analyses.…”
Section: Single Fiber Dynamic Force Measuring Setupmentioning
confidence: 99%
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“…Fry et al (1997) partly support this suggestion showing that each studied subject expressed the same titin isoforms in VL, GA, and SOL, and both a 16-week aerobic rowing and a 6-week sprint cycling training protocols did not appear to affect titin isoform composition. Toursel et al (2002) showed, however, that changes in passive tension could occur without changes in titin isoform expression in single fibers in unloaded rat SOL muscles. Interestingly one of subjects in the present and in our previous study expressed the lower-mobility titin isoform considerable more than others did.…”
Section: Discussionmentioning
confidence: 91%
“…Indeed, a significant correlation was found between the titin level (or passive force) and the sarcomeric disorganization level (as indexed by the average thick filament length) in the study by Udaka et al [28]. Titin loss has been reported in rat soleus muscle after 2 weeks of unloading in a hind-limb suspension model [92], accompanied by a reduction in passive force, but not after 3 days [93]. Therefore it is a universal phenomenon in long-term disuse.…”
Section: Disuse Atrophy Of Skeletal Muscle: a Titin Diseasementioning
confidence: 91%