1995
DOI: 10.1007/bf02064185
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Abstract: The aim was to study and compare the passive biomechanical wall properties in the isolated duodenum and distal ileum of the guinea pig in vitro. The organ bath contained a Krebs-Ringer solution with 10(-2) M MgCl2 to abolish smooth muscle contractile activity. Stepwise inflation of an intraluminal balloon, in which the cross-sectional area (CSA) was measured, provided the distension stimulus. The circumferential wall tension-strain distributions and wall stiffness-strain relations were computed from steady-sta… Show more

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Cited by 26 publications
(18 citation statements)
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“…Some studies have provided data on the small intestine [9][10][11]17] . However, many aspects are still left largely unexplored.…”
Section: Discussionmentioning
confidence: 99%
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“…Some studies have provided data on the small intestine [9][10][11]17] . However, many aspects are still left largely unexplored.…”
Section: Discussionmentioning
confidence: 99%
“…Hence, biomechanical properties are of particularly functional importance. Data in the literature pertaining to the passive mechanical properties of small intestine were concerned with the length-tension relationship in circular and longitudinal tissue strips [6][7][8] , the compliance [9] , and the stress-strain relationship of the intact wall [10,11] . However, a complete biomechanical analysis of GI physiology requires a full set of data describing the geometric properties and a valid reference state.…”
Section: Introductionmentioning
confidence: 99%
“…Hence, in the last decade, biomechanical data obtained by balloon distension or bolus injection have gained increasing interest in motility research. Data in the literature pertaining to the mechanical aspects of duodenal function are concerned with the contraction patterns (6,19,27), the length-tension relationship in circular and longitudinal tissue strips in vitro (36), flow patterns (33), compliance, and tension-strain relationship (29). Conventional methods, such as manometry and radiology do not provide exact assessment of CSA and distensibility during luminal balloon distension; volume-based systems suffer from errors due to elongation of the balloon, contraction-induced volume variations, and compressibility of the air; and ultrasound systems are quite expensive.…”
Section: Mechanical Aspectsmentioning
confidence: 99%
“…In the present study, we quantified the active and passive length-tension components in the human intestine in vivo. It is well known that the passive elastic behavior of biological tissues is exponential (15,16,29). The exponential behavior protects the organs including Fig.…”
Section: Mechanical Aspectsmentioning
confidence: 99%
“…One study showed that diabetes altered the tension-strain relation of the small intestine in a way consistent with stiffening of the intestinal wall [10]. In recent years, the passive biomechanical properties of the normal and diseased intestinal wall have been studied extensively in humans and animals [11,12,13,14,15,16,17,18,19]. We consider the zero-stress state, residual strain and stressstrain relationship of the intestinal wall as the relevant quantitative remodelling parameters because they are measures of the non-uniformity of growth or resorption in different parts of the intestinal wall.…”
mentioning
confidence: 99%