Abstract:Focused ultrasound (FUS) combined with microbubbles is an attractive method to deliver therapeutic agents to brain tissue noninvasively, transiently and locally such as antibodies, gene vectors, liposomal drugs. The objective of this study is to investigate passive delivery outcome of liposomes after ultrasound mediated blood-brain barrier (BBB) disruption. Microbubbles were injected intraveneously through mice tail vein at 0.1 μL/g. Focused ultrasound (center frequency: 1.2819 MHz) was applied to mice brains … Show more
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