2004
DOI: 10.1007/s00280-004-0858-2 View full text |Buy / Rent full text
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Abstract: No striking differences in toxicity appeared between the two etoposide formulations, but this retrospective study seemed to confirm the appearance of particular cutaneous and anal side effects especially with two associations: (1) etoposide-ifosfamide (OS 94 and Ewing 97), and (2) etoposide-ifosfamide-Adriamycin-vincristine (VIDE course of the Euro-Ewing 99 protocol).

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“…Condyloma acuminata treated with podophyllin may show atypical mitoses simulating squamous cell carcinoma. 46 Castaño et al 34 found that keratinocyte dysplasia, defined by alteration of architecture and maturation of keratinocytes along with cytological atypia, was a frequent finding after transplantation or diverse chemotherapy regimens in a series of 44 patients. 37 However, considering the large number of patients receiving combined chemotherapy with this drug, some authors believe that these reactions may result from some particular associations of chemotherapeutic agents rather than from etoposide alone.…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Condyloma acuminata treated with podophyllin may show atypical mitoses simulating squamous cell carcinoma. 46 Castaño et al 34 found that keratinocyte dysplasia, defined by alteration of architecture and maturation of keratinocytes along with cytological atypia, was a frequent finding after transplantation or diverse chemotherapy regimens in a series of 44 patients. 37 However, considering the large number of patients receiving combined chemotherapy with this drug, some authors believe that these reactions may result from some particular associations of chemotherapeutic agents rather than from etoposide alone.…”
Section: Discussionmentioning
“…37 However, considering the large number of patients receiving combined chemotherapy with this drug, some authors believe that these reactions may result from some particular associations of chemotherapeutic agents rather than from etoposide alone. 46 Castaño et al 34 found that keratinocyte dysplasia, defined by alteration of architecture and maturation of keratinocytes along with cytological atypia, was a frequent finding after transplantation or diverse chemotherapy regimens in a series of 44 patients. In this series, busulphan and cyclophosphamide were significantly associated with severe keratinocytic dysplasia, whereas two patients treated with docetaxel showed no keratinocytic dysplasia.…”
Section: Discussionmentioning
“…The rapid expansion of novel anticancer agents has resulted in significant advances in the treatment of cancer patients but has also broadened the spectrum of cutaneous adverse events. Conventional chemotherapeutic agents are well known to cause cutaneous reactions including hand‐foot syndrome (palmoplantar erythrodysesthesia), neutrophilic eccrine hidradenitis, radiation recall dermatitis, alopecia, hyperpigmentation, urticarial hypersensitivity reaction and sclerotic reactions among many others. Although the classic cutaneous reactions associated with chemotherapy agents are well known, the histopathologic characteristics of reactions caused by the many novel anticancer agents are under‐recognized.…”
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“…As with systemic MTX use, systemic etoposide use also has potential side effects, including the classic side effects (e.g., hematologic and digestive toxicities) and cutaneous side effects-palmarplantar eruptions and nail inflammation, irritation of the anal area and anal fissures, and alopecia (17). Direct and local injection of etoposide might decrease the side effects of systemic use.…”
Section: Discussionmentioning