2015
DOI: 10.2174/1381612821666151008125117
|View full text |Cite
|
Sign up to set email alerts
|

Particle Engineering of Excipients for Direct Compression: Understanding the Role of Material Properties

Abstract: Tablets represent the preferred and most commonly dispensed pharmaceutical dosage form for administering active pharmaceutical ingredients (APIs). Minimizing the cost of goods and improving manufacturing output efficiency has motivated companies to use direct compression as a preferred method of tablet manufacturing. Excipients dictate the success of direct compression, notably by optimizing powder formulation compactability and flow, thus there has been a surge in creating excipients specifically designed to … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
21
0
1

Year Published

2019
2019
2022
2022

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 47 publications
(22 citation statements)
references
References 0 publications
0
21
0
1
Order By: Relevance
“…Direct-compression is a tablet manufacturing process with well-known advantages in the pharmaceutical industry, as it requires fewer processing stages and a reduction of the final product cost. However, the powder mixture should have acceptable flow and compression properties in order to obtain tablets with content uniformity and adequate physical characteristics [ 19 , 20 , 21 , 22 ].…”
Section: Introductionmentioning
confidence: 99%
“…Direct-compression is a tablet manufacturing process with well-known advantages in the pharmaceutical industry, as it requires fewer processing stages and a reduction of the final product cost. However, the powder mixture should have acceptable flow and compression properties in order to obtain tablets with content uniformity and adequate physical characteristics [ 19 , 20 , 21 , 22 ].…”
Section: Introductionmentioning
confidence: 99%
“…Hydrophilic polymers have been used in controlled release preparations for the last 50 years [5,6,7]. A diverse range of numerous polymers, varying in their origin (natural, semi-synthetic, and synthetic) and mechanism of action have been used in sustained release dosage forms.…”
Section: Introductionmentioning
confidence: 99%
“…The multiple is much larger than the density and morphology of the powder particles. Therefore, the uniformity of the particle size of the powder mixing system becomes the most important factor when determining the uniform dispersion of different particles, and is also the most important data for detecting the uniformity of product mixing [7], [29]- [31]. In short, the better the particle size uniformity of the powder system composition is, the more similar the motion characteristics of the particles during the mixing process would be, and the better the degree of dispersion between the different types of particles would be when the uniformity of the mixture obtained after the mixing process is higher.…”
Section: ) Sieving Processmentioning
confidence: 99%