Participation of histamine H1 and H2 receptors in passive cutaneous anaphylaxis-induced scratching behavior in ICR mice

Inagaki, Nobuya; Nakamura, Nobuaki; Nagao, Masafumi; Musoh, Keiichi; Kawasaki, Hiromu; Nagai, Hiroichi

doi:10.1016/s0014-2999(98)00974-1

Cited by 77 publications

(68 citation statements)

References 22 publications

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“…Terfenadine at the same dose significantly inhibited scratching induced by histamine. 15) Taking into account these findings, the present results suggest that Sophora flavescens and Cnidium monnieri produce antipruritic action through non-histamine systems.…”

Section: Discussionmentioning

confidence: 50%

Antipruritic Effects of Sophora flavescens on Acute and Chronic Itch-Related Responses in Mice

Yamaguchi-Miyamoto

Kawasuji

Kuraishi

et al. 2003

Biological & Pharmaceutical Bulletin

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Pruritus is a dominant symptom of many dermatologic disorders (e.g., atopic dermatitis, contact dermatitis and urticaria), and is a frequent manifestation of several systemic diseases (e.g., chronic renal failure and cholestasis). Antihistaminic and anti-allergic drugs are generally prescribed for cutaneous pruritus. However, histamine is not considered to be the major pruritogen in atopic dermatitis, [1][2][3] because histamine H 1 receptor antagonists do not generally depress itch and scratch in patients. Thus, the mechanism of itch in atopic dermatitis is still unclear, and effective treatment is not established.Kampo formulas (traditional Chinese and Japanese herbal medicinal mixtures) are widely used in the clinical treatment of allergic and inflammatory dermatitis in Japan. In some cases, dermatitis improves after Kampo treatment, but the pharmacological characteristics and mechanisms of their action are obscure. Recently, 33 herbal medicines were screened for inhibitory effects on substance P (SP)-induced scratching in mice. 4) However, herbal medicines have not been screened for inhibitory effects on chronic itch-related responses.Previously, we established 5-HT-induced scratching in mice as an acute itch model. 5) 5-HT is pruritogenic in humans, and is suggested to be involved in some pruritic diseases. [6][7][8] We have shown that 5-HT elicits scratching of the treated skin by the hind paws in mice, and that the 5-HT-induced scratching has features similar to those of human itching. 5) The mechanisms of 5-HT-induced scratching may be different from those of SP-or histamine-induced scratching. 9) NC mice are claimed to be a model of atopic dermatitis. 10) When maintained for a long time in a conventional environment, the NC mouse spontaneously and frequently scratches its face, ears and rostral part of the back by the hind paws. 11) We have shown that the spontaneous scratching is thought to be a model of itch-related response in atopic dermatitis. 12) The purpose of the present study is to find new antipruritic herbal medicines that are also effective in treating chronic itch. We screened seven herbal medicines which have been used to treat dermatologic diseases, testing them on mouse models of itch. MATERIALS AND METHODS Plant MaterialsThe root of Angelica acutiloba and the root of Saposhnikovia divaricata were provided by the Toyama Medicinal Plant Research Center (Kamiichi, Japan). The fruits of Cnidium monnieri, the root of Cnidium officinale, the fruits of Forsythia suspense, the aerial part of Schizonepeta tenuifolia and the root of Sophora flavescens were purchased from Enjyudo (Toyama, Japan). Fifty grams of crude drugs were extracted three times with methanol (300 ml once, 200 ml twice) for 3 h. The decoctions were evaporated under reduced pressure and dried.Animals Male ICR mice (Japan SLC, Ltd., Shizuoka, Japan) at 4 to 6 weeks of age were used. NC/Jic mice (male, 4-7 months old) were kept for a long time under conventional conditions to induce chronic itch-related responses, as described. 1...

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Section: Discussionmentioning

confidence: 50%

Antipruritic Effects of Sophora flavescens on Acute and Chronic Itch-Related Responses in Mice

Yamaguchi-Miyamoto

Kawasuji

Kuraishi

et al. 2003

Biological & Pharmaceutical Bulletin

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“…There are four subtypes of histamine receptors, namely H1R1 to 4 that are members of the GPCR family. Among them H1R1, 3, and 4 are detected in skin-innervating sensory neurons [21,22] . In humans, histamine-induced itch reactions are almost completely suppressed by a H1R1 inhibitor [23] , whereas, in mice, H1R4 contributes to the itch signal as well [24] .…”

Section: Peripheral Mechanisms Of Itch and Painmentioning

confidence: 99%

Molecular Mechanisms of Itch and Pain: An Overview

Lee

2015

Itch Pain

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Itch and pain are two distinct sensory modalities elicited by noxious and pruritic stimuli, respectively. The cellular and electrophysiological characteristics of itch and pain are very similar; thus discerning the mechanical difference between these two sensory modalities has long been elusive. Recent advances in this field have revealed various neuronal receptors responsible for itch and pain signal transduction and transmission. These studies have identified a distinct sub-population of sensory neurons responsible for itch signal transduction. In addition, itch and pain information conveyed to the spinal cord are processed and regulated by distinct spinal cord neurons. Although both itch and pain senses are required for our daily lives, chronic and hyper-sensation of itch and pain results in a debilitating disease state. Studies have now begun to elucidate mechanisms for the sensitization of pain and itch and also to unravel counter-regulatory mechanisms between itch and pain at the spinal cord level. Interestingly, toll-like receptors (TLRs), an innate immune receptor, has been implicated in the central sensitization of both pain and itch. In this review, we will briefly provide an overview of the molecular mechanisms of itch and pain. Additionally, we will discuss the recently uncovered role of TLRs in itch and pain sensation.

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“…For scientific purpose, many experiments have been conducted to evaluate mice scratching. These experiments involve the administration of the compound 48/80 R. C. Benyon (1986), histamine N. Inagaki (1999), and serotonin J. S. Thomsen (2002) and acetone or ether painting on animals to induce a dry skin T. Miyamoto (2002).…”

Section: State Of the Artmentioning

confidence: 99%