Partially absorbable meshes for hernia repair offer advantages over nonabsorbable meshes

Bellón, Juan M.; Rodrı́guez, Marta; García‐Honduvilla, Natalio; Pascual, Gemma; Buján, Julia

doi:10.1016/j.amjsurg.2006.11.016

Cited by 70 publications

(41 citation statements)

References 12 publications

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“…In the case of Utrabo et al 4 , the tensiometry showed a significant difference between the polypropylene and the polypropylene/poliglecaprone groups when analyzing the force of the rupture of the abdominal wall after sixty days, with the force being greater in the polypropylene/ poliglecaprone. These findings diverge from those of Bellón et al 21 and the results of the present study.…”

Section: Discussioncontrasting

confidence: 57%

“…In the study conducted by Bellón et al 21 , the evaluation of resistance to traction was similar on both occasions under study, the fourteenth and the ninetieth days. In the case of Utrabo et al 4 , the tensiometry showed a significant difference between the polypropylene and the polypropylene/poliglecaprone groups when analyzing the force of the rupture of the abdominal wall after sixty days, with the force being greater in the polypropylene/ poliglecaprone.…”

Section: Discussionmentioning

confidence: 96%

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Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats

et al. 2014

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PURPOSE:To compare the inflammatory reaction and the growing resistance of the abdominal wall with the use of poliglecaprone meshes and polypropylene meshes associated with poliglecaprone in the correction of abdominal defects. METHODS:Seventy-seven Wistar rats were divided into three groups: CG (non-operated animals: EG (polypropylene mesh) and UG (polypropylene and poliglecaprone mesh). A muscular and aponeurotic defect was formed and treated according to the group.Evaluations were made after 4, 7, 14, 28 and 56 days. The resistance and inflammatory pattern were studied. RESULTS:There was a gradual and significant gain in resistance, regularly in the EG and irregularly in the UG, which was lower on the 14 th day (p=0.008). The inflammatory reaction was acute and more intense in the UG on the fourth day. At all other times, the inflammatory pattern was acute to chronic, similar in both groups, with minimum intensity on the 56 th day. CONCLUSION:The greater resistance offered by the polypropylene mesh was regular and ascending, stabilizing on the 28 th day, while that of the polypropylene/poliglecaprone was not even. In the end, the resistances were similar. The inflammatory response was greater in the UG on the fourth day and similar at all other times.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 96%

Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats

et al. 2014

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“…The defect area after three weeks ranged from 32.1±5.5 to 35.6±3.1 squared centimeters and was similar to other reports that made only the acute full-thickness defect with areas ranging from 35 to 40 squared centimeters 9,10,18,[30][31][32][33][34][35][36][37][38] . The hypothetic advantage of our model was to simulate the surgical findings in the human hernia repair.…”

Section: Discussionsupporting

confidence: 71%

“…The consensus or a reliable algorithm to hernia treatment remains a challenge [1][2][3][4][5] . In the same way, the reports using animals have limiting points like the use of different species, mainly rats [6][7][8] , rabbits [9][10][11] and pigs [12][13][14] , and different procedures to promote the model of hernia to be used for the further technique and/or mesh reinforce. Most of them make an acute defect by provoking a hole on the abdominal wall, which is immediately repaired.…”

Section: Introductionmentioning

confidence: 99%

Animal model of chronic abdominal hernia in rabbit

Silva

Fagundes

Seidel³

et al. 2009

Acta Cir. Bras.

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Purpose: To create a feasible animal model of hernia that should be reliable to test the different types of mesh and/or surgical technique. Methods: Thirty six male New Zealand albino rabbits were submitted to surgical procedure to provoke a standard hole in the abdominal wall. A metallic frame measuring 3 cm length and 1 cm width was allocated longitudinally on the umbilicus scar and the comprehensive three squared centimeters area was resected. A continuous 4.0 polyamide was performed to closure the subcutaneous and skin. Results: During three weeks a score of signals/symptoms was performed to evaluate the wound and clinical conditions. No death or severe complications occurred. In the 3rd week the hernia ring and visceral adhesions were evaluated. Soft omental adherences were present in the hernial sac in all animals. The area of hernia ring ranged from 32.1±5.5 to 35.6±3.1 squared centimeter and the maximum was 39 cm 2 and the minimum was 30 cm 2 . The model results in protrusion which was similar to a human incisional hernia with hernia sac, visceral adhesions and fibrous healing ring. Conclusion: The model was more reliable to test further techniques or mesh on hernia repair. Key words: Hernia, Ventral. Hernia, Abdominal. Wound Healing. Animal Experimentation. Rabbits. RESUMO Objetivo:Criação de um modelo animal de hérnia que seja confiável para testar as diferentes técnicas e tipos de telas. Métodos: Trinta e seis coelhos foram submetidos a procedimento operatório que provocou uma falha na parede abdominal. Uma moldura metálica com 3 cm de comprimento e 1 cm de largura foi colocada longitudinalmente sobre a cicatriz umbilical e ressecada uma área de 3cm 2 . Uma sutura contínua de poliamida 4.0 fechou a tela subcutânea e pele. Resultados: durante três semanas o escore de sinais e sintomas foi coletado para avaliar as condições clínicas e da ferida operatória. Não ocorreram óbitos ou complicações graves. Na terceira semana o anel herniário e aderências peritoneais foram avaliadas. Aderências frouxas estavam presentes no saco herniário em todos os animais. A área do anel herniário variou de 32.1±5.5 a 35.6±3.1 cm 2 , com um máximo de 39 cm 2 e um mínimo de 30 cm 2 . O modelo resultou numa protrusão de vísceras semelhante ao que ocorre em hérnia incisional de humanos. Conclusão: O modelo é factível para testar técnicas operatórias ou telas na reconstrução de hérnias incisionais.

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“…These findings are in agreement with the classical ones described in the literature for wound healing 11 but do not reproduce the results found by other authors, who show an increase in type III collagen 26,29 . Bellón et al 30 carried out a study with rabbits and observed that type III collagen fibers were predominant 2 weeks after polypropylene mesh implantation. Bogusiewicz et al 29 assessed collagen deposition on polypropylene meshes in rats and found that 70% of the collagen was immature (type III) 42 days after surgery.…”

Section: Discussionmentioning

confidence: 99%

Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

et al. 2009

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RESUMOObjetivo: Avaliar o tempo de fibroplasia em tela de polipropileno na correção de hérnias incisionais da parede abdominal, em ratos, através da quantidade de colágeno, correlacionando-o com a resposta inflamatória local. Métodos: Trinta e seis ratos machos da linhagem Wistar foram submetidos à ressecção longitudinal de um segmento músculo-aponeurótico e peritoneal (3x2 cm) da parede abdominal, seguida por reforço com tela de polipropileno, em forma de ponte sobre a aponeurose. Os animais foram distribuídos em seis grupos, de acordo com o tempo de fibroplasia a ser estudado (1, 2, 3, 7, 21 e 30 dias de pós-operatório). Após os prazos estabelecidos para estudo da fibroplasia, os animais foram submetidos à eutanásia, e a área de fixação da tela de polipropileno foi avaliada histologicamente quanto à reação inflamatória e à percentagem de colágeno pela técnica videomorfométrica assistida por computador. Resultados: Houve aparecimento de colágeno total junto à tela no 3º dia pós-implante, com aumento progressivo na sua proporção em todos os dias subseqüentes até o 21º dia, quando atingiu sua proporção máxima (p<0,001). A partir do dia 3, o colágeno III sofreu um aumento progressivo até o dia 21, quando atingiu sua proporção máxima (p<0,001), e no 30º dia apresentou uma redução significativa (p<0,001). O colágeno tipo I surgiu entre o 7º e o 21º dia, apresentou sua máxima proporção no 21º dia e manteve-se inalterado até o final do período de observação. A relação colágeno tipo I/tipo III aumentou progressivamente e inverteu-se no 30º dia de observação (p<0,001). Os neutrófilos foram identificados no 1º dia pós-implante, mantendo-se junto à tela até o 21º dia. Os macrófagos, gigantócitos e linfócitos foram identificados no 2º dia. Trinta dias após a implantação da tela, desapareceram os neutrófilos e mantiveram-se estáveis as proporções de macrófagos, gigantócitos e linfócitos (p<0,001). Conclusões: Os resultados do presente estudo evidenciaram a presença de colágeno no 3º dia pós-implante, com predomínio do colágeno tipo I ao final do período de observação. O prolongamento da resposta inflamatória da cicatrização e a persistência do processo inflamatório crônico junto à tela não interferiram no tempo da fibroplasia. Descritores: Parede Abdominal. Colágeno. Hérnia. Telas Cirúrgicas. Polipropilenos. Neutrófilos. Ratos. ABSTRACT Purpose:This study assessed the collagen deposition and correlated it with local inflammatory responses to evaluate the length of time required for fibroplasia when polypropylene meshes are used to repair incisional abdominal wall hernias in rats. Methods: Thirty-six male Wistar rats underwent longitudinal resection of a peritoneal and musculoaponeurotic tissue segment (3x2 cm) of the abdominal wall followed by defect reconstruction with polypropylene mesh bridging over aponeurosis. The animals were divided into 6 groups according to the time points for the analysis of fibroplasia: 1, 2, 3, 7, 21 and 30 days post-implantation. Animals were sacrificed at each time point, and the site where th...

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Partially absorbable meshes for hernia repair offer advantages over nonabsorbable meshes

Cited by 70 publications

References 12 publications

Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats

Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats

Animal model of chronic abdominal hernia in rabbit

Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

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