Wereport here findings in a 51-year-old Japanese man with non-insulin-dependent diabetes mellitus whocomplained of exercise-induced cramps. Muscle biopsy showed scattered regenerating fibers, small angular fibers and increased PAS positive particles. Electron microscopic examination revealed an abnormal accumulation of glycogen particles in subsarcolenmmal areas and between myofibrils while chemical studies showedan increased glycogen concentration and decreased phosphoglycerate mutase (PGAM), 46.9% of the no…
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