Partial Agenesis of the Corpus Callosum

Agenesis of the Corpus Callosum

“…Total absence of the septum lucidum and hippocampal commissure is found with complete agenesis though, unlike our case, the body and columns of the fornix are usually present (Baker and Graves, 1933). Other anomalies often reported include cranial nerve defects, incomplete separation of the frontal lobes, hydrocephalus, porencephaly, arrhinencephaly, microcephaly and dilatation of the cisterna magna (Bouchier, 1957).…”

“…Reil (1812) published the first report of a case, describing the necropsy findings in a 30 year old woman of low mentality; further cases discovered at necropsy were subsequently reported (Urquardth, 1880; Richter, 1886;Bruce, 1889;Dunn, 1889;Cameron, 1917;de Large, 1925). Baker and Graves (1933) reviewed 83 cases, in a wide variety of age groups, first diagnosed at necropsy. The diagnosis during life was first made by Davidoff and Dyke (1934) using pneumo-encephalography; the pneumo-encephalographic features had been observed by Guttman (1929) but their significance was not appreciated until necropsy revealed complete agenesis.…”

Agenesis of the Corpus Callosum

“…Total absence of the septum lucidum and hippocampal commissure is found with complete agenesis though, unlike our case, the body and columns of the fornix are usually present (Baker and Graves, 1933). Other anomalies often reported include cranial nerve defects, incomplete separation of the frontal lobes, hydrocephalus, porencephaly, arrhinencephaly, microcephaly and dilatation of the cisterna magna (Bouchier, 1957).…”

“…Reil (1812) published the first report of a case, describing the necropsy findings in a 30 year old woman of low mentality; further cases discovered at necropsy were subsequently reported (Urquardth, 1880; Richter, 1886;Bruce, 1889;Dunn, 1889;Cameron, 1917;de Large, 1925). Baker and Graves (1933) reviewed 83 cases, in a wide variety of age groups, first diagnosed at necropsy. The diagnosis during life was first made by Davidoff and Dyke (1934) using pneumo-encephalography; the pneumo-encephalographic features had been observed by Guttman (1929) but their significance was not appreciated until necropsy revealed complete agenesis.…”

Magnetic Resonance Imaging of Brain Anomalies in Fetal Alcohol Syndrome

“…These previous studies have reported 13 alcohol-exposed patients with partial or complete agenesis of the corpus callosum and a 14th patient with a moderately hypoplastic corpus callosum. 26,27,30,39,40,60,61 Detailed clinical descriptions of our patients from South Dakota were recently published in a report that included 3 patients not reported here, 1 of whom could not undergo MRI scanning because of a cardiac pacemaker yet has complete agenesis of the corpus callosum as demonstrated by clinical CT scanning. 66 Dysmorphic facial features were described in detail for only three of the patients with callosal agenesis reported by others, and all three had six or more craniofacial anomalies.…”

“…26,27 Additionally, in a review of callosal agenesis, Jeret et al 39 reported nine patients with FAS and callosal agenesis. These included two of the three cases reviewed above, a presumed case of FAS reported by Baker and Graves, 40 and six previously unpublished cases of their own. 39 Jeret and Serur 41 recently predicted that FAS may account for more cases of partial or complete callosal agenesis than any other single disorder.…”

Agenesis of the Corpus Callosum

“…Reil (1812) published the first report of a case, describing the necropsy findings in a 30 year old woman of low mentality; further cases discovered at necropsy were subsequently reported (Urquardth, 1880;Richter, 1886;Bruce, 1889;Dunn, 1889;Cameron, 1917;de Large, 1925). Baker and Graves (1933) reviewed 83 cases, in a wide variety of age groups, first diagnosed at necropsy. The diagnosis during life was first made by Davidoff and Dyke (1934) using pneumo-encephalography; the pneumo-encephalographic features had been observed by Guttman (1929) but their significance was not appreciated until necropsy revealed complete agenesis.…”

Agenesis of the Corpus Callosum

“…Total absence of the septum lucidum and hippocampal commissure is found with complete agenesis though, unlike our case, the body and columns of the fornix are usually present (Baker and Graves, 1933). Other anomalies often reported include cranial nerve defects, incomplete separation of the frontal lobes, hydrocephalus, porencephaly, arrhinencephaly, microcephaly and dilatation of the cisterna magna (Bouchier, 1957).…”

“…Reil (1812) published the first report of a case, describing the necropsy findings in a 30 year old woman of low mentality; further cases discovered at necropsy were subsequently reported (Urquardth, 1880; Richter, 1886;Bruce, 1889;Dunn, 1889;Cameron, 1917;de Large, 1925). Baker and Graves (1933) reviewed 83 cases, in a wide variety of age groups, first diagnosed at necropsy. The diagnosis during life was first made by Davidoff and Dyke (1934) using pneumo-encephalography; the pneumo-encephalographic features had been observed by Guttman (1929) but their significance was not appreciated until necropsy revealed complete agenesis.…”

Magnetic Resonance Imaging of Brain Anomalies in Fetal Alcohol Syndrome

“…These previous studies have reported 13 alcohol-exposed patients with partial or complete agenesis of the corpus callosum and a 14th patient with a moderately hypoplastic corpus callosum. 26,27,30,39,40,60,61 Detailed clinical descriptions of our patients from South Dakota were recently published in a report that included 3 patients not reported here, 1 of whom could not undergo MRI scanning because of a cardiac pacemaker yet has complete agenesis of the corpus callosum as demonstrated by clinical CT scanning. 66 Dysmorphic facial features were described in detail for only three of the patients with callosal agenesis reported by others, and all three had six or more craniofacial anomalies.…”

“…26,27 Additionally, in a review of callosal agenesis, Jeret et al 39 reported nine patients with FAS and callosal agenesis. These included two of the three cases reviewed above, a presumed case of FAS reported by Baker and Graves, 40 and six previously unpublished cases of their own. 39 Jeret and Serur 41 recently predicted that FAS may account for more cases of partial or complete callosal agenesis than any other single disorder.…”

Agenesis of the Corpus Callosum

“…Reil (1812) published the first report of a case, describing the necropsy findings in a 30 year old woman of low mentality; further cases discovered at necropsy were subsequently reported (Urquardth, 1880;Richter, 1886;Bruce, 1889;Dunn, 1889;Cameron, 1917;de Large, 1925). Baker and Graves (1933) reviewed 83 cases, in a wide variety of age groups, first diagnosed at necropsy. The diagnosis during life was first made by Davidoff and Dyke (1934) using pneumo-encephalography; the pneumo-encephalographic features had been observed by Guttman (1929) but their significance was not appreciated until necropsy revealed complete agenesis.…”

Agenesis of the Corpus Callosum

“…Total absence of the septum lucidum and hippocampal commissure is found with complete agenesis though, unlike our case, the body and columns of the fornix are usually present (Baker and Graves, 1933). Other anomalies often reported include cranial nerve defects, incomplete separation of the frontal lobes, hydrocephalus, porencephaly, arrhinencephaly, microcephaly and dilatation of the cisterna magna (Bouchier, 1957).…”

“…Reil (1812) published the first report of a case, describing the necropsy findings in a 30 year old woman of low mentality; further cases discovered at necropsy were subsequently reported (Urquardth, 1880; Richter, 1886;Bruce, 1889;Dunn, 1889;Cameron, 1917;de Large, 1925). Baker and Graves (1933) reviewed 83 cases, in a wide variety of age groups, first diagnosed at necropsy. The diagnosis during life was first made by Davidoff and Dyke (1934) using pneumo-encephalography; the pneumo-encephalographic features had been observed by Guttman (1929) but their significance was not appreciated until necropsy revealed complete agenesis.…”

Magnetic Resonance Imaging of Brain Anomalies in Fetal Alcohol Syndrome

“…These previous studies have reported 13 alcohol-exposed patients with partial or complete agenesis of the corpus callosum and a 14th patient with a moderately hypoplastic corpus callosum. 26,27,30,39,40,60,61 Detailed clinical descriptions of our patients from South Dakota were recently published in a report that included 3 patients not reported here, 1 of whom could not undergo MRI scanning because of a cardiac pacemaker yet has complete agenesis of the corpus callosum as demonstrated by clinical CT scanning. 66 Dysmorphic facial features were described in detail for only three of the patients with callosal agenesis reported by others, and all three had six or more craniofacial anomalies.…”

“…26,27 Additionally, in a review of callosal agenesis, Jeret et al 39 reported nine patients with FAS and callosal agenesis. These included two of the three cases reviewed above, a presumed case of FAS reported by Baker and Graves, 40 and six previously unpublished cases of their own. 39 Jeret and Serur 41 recently predicted that FAS may account for more cases of partial or complete callosal agenesis than any other single disorder.…”

Agenesis of the Corpus Callosum

“…Reil (1812) published the first report of a case, describing the necropsy findings in a 30 year old woman of low mentality; further cases discovered at necropsy were subsequently reported (Urquardth, 1880;Richter, 1886;Bruce, 1889;Dunn, 1889;Cameron, 1917;de Large, 1925). Baker and Graves (1933) reviewed 83 cases, in a wide variety of age groups, first diagnosed at necropsy. The diagnosis during life was first made by Davidoff and Dyke (1934) using pneumo-encephalography; the pneumo-encephalographic features had been observed by Guttman (1929) but their significance was not appreciated until necropsy revealed complete agenesis.…”