2011
DOI: 10.1007/s11302-011-9274-3
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Abstract: Adenosine, a purine nucleoside, is present in all cells in tightly regulated concentrations. It has many different physiological effects in the whole body and in the heart. Adenosine activates four G protein-coupled receptors A1, A2a, A2b, and A3. Activation of myocardial A1 receptors has been shown to inhibit a variety of myocardial pathologies associated with ischemia and reperfusion injury, including stunning, arrhythmogenesis, coronary and ventricular dysfunction, acute myocardial infarction, apoptosis, an… Show more

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Cited by 78 publications
(77 citation statements)
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“…This may reflect different roles for the A 1 and A 2A receptors in voluntary alcohol consumption versus alcohol reinforcement, although future studies should more directly address this possibility. In the context of this systemic administration study, it is also important to note that A 1 and A 2A receptors are present in the periphery, largely regulating cardiovascular and inflammatory processes (Albrecht-Küpper et al, 2012, Deharo et al, 2012, Williams and Cronstein, 2012, Antonioli et al, 2013). Future efforts employing brain-region specific administration will seek to clarify the extent to which the observed effects are mediated by central or perhaps, peripheral effects.…”
Section: Discussionmentioning
confidence: 99%
“…This may reflect different roles for the A 1 and A 2A receptors in voluntary alcohol consumption versus alcohol reinforcement, although future studies should more directly address this possibility. In the context of this systemic administration study, it is also important to note that A 1 and A 2A receptors are present in the periphery, largely regulating cardiovascular and inflammatory processes (Albrecht-Küpper et al, 2012, Deharo et al, 2012, Williams and Cronstein, 2012, Antonioli et al, 2013). Future efforts employing brain-region specific administration will seek to clarify the extent to which the observed effects are mediated by central or perhaps, peripheral effects.…”
Section: Discussionmentioning
confidence: 99%
“…As a result, systemic administration of A 1 R agonists or ADK inhibitors successfully attenuates seizure activity (Fredholm, 2003; Jacobson and Gao, 2006; Boison, 2011). However, the use of systemic A 1 R agonists, ADK inhibitors or adenosine as a therapeutic strategy for epilepsy treatment is limited due to negative side effects including bradycardia, vasoconstriction in the kidney and sedation (Albrecht-Kupper et al, 2012). Thus, it is imperative that novel therapeutic approaches, which focally restore normal adenosine levels, are developed for epilepsy treatment.…”
Section: Conclusion and Clinical Relevancementioning
confidence: 99%
“…AR activation inhibits fibroblast proliferation and collagen synthesis,8,9 thus limiting cardiac tissue remodeling and progression to failure. Moreover, activated ARs have favorable regulatory effects on several phenomena associated with ischemic and pressure-overload insults, including cytokine release,10,11 cell death processes,12 and oxidative stress 13,14…”
Section: Introductionmentioning
confidence: 99%