Parsiguine, A Novel Antimicrobial Substance from<i>Fischerella ambigua</i>

Ghasemi, Younes; Yazdi, Mojtaba Tabatabaei; Shafiee, Abbas; Amini, Mohsen; Shokravi, Shadman; Zarrini, Gholamreza

doi:10.1080/13880200490511918

Cited by 92 publications

(51 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…chlorellin, was found to be responsible for that inhibitory activity against both Gram+ and Grambacteria. Research aimed at identifying antibacterial active principles produced by microalgae has meanwhile boomed [68]. This realisation arose e.g.…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…Hence, discovery of novel antibacterial compounds following distinct biochemical mechanisms of action is urged. Antibiotics are typically less effective against Gram-bacteria because of their complex, multilayered cell wall structure -which makes it more difficult for the active compound to penetrate them [69]; this justifies why the antibacterial activity of the supernatant (and methanolic extracts) is more potent against Gram+ than Gram-bacteria [68,70]. The exact mechanism of action of fatty acids remains unknown: they may act upon multiple cellular targets, even though cell membranes are the most probable ones -as membrane damage will likely lead to cell leakage and reduction of nutrient uptake, besides inhibiting cellular respiration; conversely, Desbois [71] claimed a peroxidative process.…”

Section: Antibacterial Activitymentioning

confidence: 99%

See 1 more Smart Citation

Microalgal Biotechnology: Prospects and Applications

Mostafa¹

2012

Plant Science

View full text Add to dashboard Cite

Plant Science 276composition, pigments and different constituents which may vary with salt stressed culture conditions and describe the antioxidant characteristics of algae. What are microalgae?Microalgae are prokaryotic or eukaryotic photosynthetic microorganisms that produce carbohydrates, proteins and lipids as a result of photosynthesis. They can grow rapidly and live in harsh conditions due to their unicellular or simple multicellular structure. Examples of prokaryotic microorganisms are Cyanobacteria (Cyanophyceae) and eukaryotic microalgae are for example green algae (Chlorophyta) and diatoms (Bacillariophyta). Microalgae are present in all existing earth ecosystems, not just aquatic but also terrestrial, representing a big variety of species living in a wide range of environmental conditions. It is estimated that more than 50,000 species exist, but only a limited number, of around 30,000, have been studied and analyzed [4]. Sunlight, water, nutrients and arable land are the major requirements for growing algae. Micro algae have the ability to fix CO2 using solar energy with efficiency 10 times greater than that of the terrestrial plants with numerous additional technological advantages. Algae are more efficient at utilizing sunlight than terrestrial plants, consume harmful pollutants, have minimal resource requirements and do not compete with food or agriculture for precious resources [5].

show abstract

Section: Antibacterial Activitymentioning

confidence: 99%

Section: Antibacterial Activitymentioning

confidence: 99%

Microalgal Biotechnology: Prospects and Applications

Mostafa¹

2012

Plant Science

View full text Add to dashboard Cite

show abstract

“…Nostoc commune diterpenoids antibacterial, molluscicidal [7] Anabaena constricta indole alkaloid antimicrobial [8] Tolypotrix byssoidea peptides antifungal [9] Fischerella ambigua "parsiguine" antibacterial, antifungal [10] Brazilian isolates nonribosomal peptides antimicrobial [11] Synechocystis sp. Gracilaria lemaneiformis R-phycoerythrin free radicals scavenger, antitumor [42] suppressing effect on MCF-7 cancer cells even at a very low concentration (0.1 μg mL -1 ) [33].…”

Section: Cyanophytamentioning

confidence: 99%

Biological activity of microalgae can be enhanced by manipulating the cultivation temperature and irradiance

Gacheva

Gigova

2014

Open Life Sciences

View full text Add to dashboard Cite

The escalating levels of antibiotic resistance among pathogenic bacteria and the side effects of chemotherapeutic drugs in use forced the efforts of scientists to search for natural antimicrobial and anticancer substances with novel structures and unique mechanism of action. Focusing on bioproducts, recent trends in drug research have shown that microalgae (including the cyanobacteria) are promising organisms to furnish novel and safer biologically active compounds. Many microalgal metabolites have been found to possess potent antibacterial, antifungal, antiviral, anticancer and antiinflammatory activities, as well as antioxidant, enzyme inhibiting and immunostimulating properties. In this paper, the studies on the biological activity of microalgae associated with potential medical and pharmaceutical applications are briefly presented. Attention is focused on the impact of cultivation temperature, irradiance and growth stage on the biomass accumulation, activity and pathways of cell metabolism and the possibilities of using these variable factors to increase the diversity and quantity of biologically active substances synthesized by microalgae.

show abstract

“…Microalgae have meanwhile been found to produce antibiotics. A large number of microalgal extracts and/or extracellular products have proven antibacterial, antifungal, antiprotozoal and antiplasmodial [6][7][8][9][10][11][12][13]. Efforts to identify the compounds directly responsible for those antimicrobial features have been made, but are still embryonic.…”

Section: Introductionmentioning

confidence: 99%