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Cited by 51 publications
(16 citation statements)
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“…The optimum pH for acid lysis of both platelets and erythrocytes from our patients was approximately 6.4 (Fig. 6), a value lower than that of about 6.8-7.0 obtained by other workers (19,32,33), but close to that of 6.5 described by Yachnin and Ruthenberg (34) and Kan and Gardner (35) and identical with the value of 6.4 reported recently by Kann, Mengel, Meriwether, and Ebbert (36). No explanation has been advanced for the apparently discrepant values obtained by various workers for the pH optimum, but it may be significant that the lower values of pH (6.4-6.5) have been obtained when the reaction mixtures were overlain with oil to prevent a change in pH during incubation.…”
Section: Resultscontrasting
confidence: 63%
See 1 more Smart Citation
“…The optimum pH for acid lysis of both platelets and erythrocytes from our patients was approximately 6.4 (Fig. 6), a value lower than that of about 6.8-7.0 obtained by other workers (19,32,33), but close to that of 6.5 described by Yachnin and Ruthenberg (34) and Kan and Gardner (35) and identical with the value of 6.4 reported recently by Kann, Mengel, Meriwether, and Ebbert (36). No explanation has been advanced for the apparently discrepant values obtained by various workers for the pH optimum, but it may be significant that the lower values of pH (6.4-6.5) have been obtained when the reaction mixtures were overlain with oil to prevent a change in pH during incubation.…”
Section: Resultscontrasting
confidence: 63%
“…While the existence of an erythrocyte abnormality in patients with PNH seems unequivocal (2,3), no conclusive evidence has been presented to indicate that platelets or leukocytes are qualitatively abnormal. In studies here described, the immunologic reactivity of platelets and leukocytes from patients with PNH was compared with that of normal platelets and leukocytes using release of an isotopic label, 'Cr, as a measure of immune injury.…”
Section: Introductionmentioning
confidence: 99%
“…folic acid (and who per haps would not be treated by another phy sician and thus be in group 2), to those pa tients with continuing severe disease char acterised by life-threatening haemolytic and thrombotic episodes. Similar findings were reported in other large series where 10-15°/c of patients showed complete rec overy but the overall mortality was more than 50% [23], the median survival being 10 years [6], In the current series, survival has ranged from less than 1 year to 30 years; in group 4 patients the median sur vival was 3.5 years.…”
Section: Course and Outcomesupporting
confidence: 90%
“…The PNH hemolytic system is known to be highly sensitive to serum dilution (22). Figure 4 demonstrates that poly I enhancement of PNHE hemolysis is also destroyed by a 1: 4 dilution of serum both at pH 6.5 and 7.6.…”
Section: Resultsmentioning
confidence: 99%