Paroxysmal burning pain caused by erythromelalgia

Kondo, Takeshi; Uehara, Takanori; Ikegami, Akiko; Ikusaka, Masatomi

doi:10.1016/s0140-6736(14)60655-3

Cited by 11 publications

(9 citation statements)

References 4 publications

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“…Small fiber neuropathy involves preferentially the axon terminals of long neural nerves affecting frequently the feet. 49 , 50 …”

Section: Pathophysiologymentioning

confidence: 99%

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Erythromelalgia: a cutaneous manifestation of neuropathy?

Leroux¹

2018

An. Bras. Dermatol.

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The low prevalence of erythromelalgia, classified as an orphan disease, poses diagnostic and therapeutic difficulties. The aim of this review is to be an update of the specialized bibliography. Erythromelalgia is an infrequent episodic acrosyndrome affecting mainly both lower limbs symmetrically with the classic triad of erythema, warmth and burning pain. Primary erythromelalgia is an autosomal dominant inherited disorder, while secondary is associated with myeloproliferative diseases, among others. In its etiopathogenesis, there are neural and vascular abnormalities that can be combined. The diagnosis is based on exhaustive clinical history and physical examination. Complications are due to changes in the skin barrier function, ischemia and compromise of cutaneous nerves. Because of the complexity of its pathogenesis, erythromelalgia should always be included in the differential diagnosis of conditions that cause chronic pain and/or peripheral edema. The prevention of crisis is based on a strict control of triggers and promotion of preventive measures. Since there is no specific and effective treatment, control should focus on the underlying disease. However, there are numerous topical and systemic therapies that patients can benefit from.

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“…Small fiber neuropathy involves preferentially the axon terminals of long neural nerves affecting frequently the feet. 49 , 50 …”

Section: Pathophysiologymentioning

confidence: 99%

“…The opening of arteriovenous anastomoses with the consequent flow increase leads to a decrease of the capillary circulation, diminishing the oxygenated blood and producing hypoxia and tissue pain. 49 , 54 - 57 …”

Section: Pathophysiologymentioning

confidence: 99%

Erythromelalgia: a cutaneous manifestation of neuropathy?

Leroux¹

2018

An. Bras. Dermatol.

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“…Another consequence of neural and vascular interaction in EM is that associated anhidrosis or hypohidrosis results from thermoregulatory impairment of sweat glands. Cooling the limbs relieves the symptoms but does not improve the erythema, due to the reduced vasoconstriction mentioned above [5].…”

Section: Clinical Lettermentioning

confidence: 97%

“…Reflex stimulation of the adrenergic system results in less vasoconstriction in the acral skin than in other areas [1]. Nerve damage explains the dysfunction of the microcirculation that causes the symptoms of EM [5]. The increased perfusion of the affected limb is paradoxically associated with tissue ischemia, due to an abnormal distribution of the microvascular flow through arteriovenous pre-capillary shunts.…”

Section: Clinical Lettermentioning

confidence: 99%

Post‐operative erythromelalgia treated with calcium channel blockers

Mostafa

Khedr

2022

J Deutsche Derma Gesell

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“…Согревание конечностей приводит к усилению болевых ощуще-ний, а охлаждение, придание горизонтального поло-жения телу с приподниманием ног облегчает состоя-ние ребенка. Приступ может длиться от пары минут до нескольких дней [1,11,12].…”

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Идиопатическая Манифестация Синдрома Митчелла (Эритромелалгии) У Ребенка

Samoilenko

Chernyshova

Dolynskyi

et al. 2021

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Синдром Митчелла (эритромелалгия) — редкое заболевание в педиатрической практике. В статье описан случай наблюдения эритромелалгии у ребенка 10 лет. Отмечена специфическая для данного заболевания клиническая картина, трудности диагностики в практике врача-педиатра.

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Paroxysmal burning pain caused by erythromelalgia

Cited by 11 publications

References 4 publications

Erythromelalgia: a cutaneous manifestation of neuropathy?

Erythromelalgia: a cutaneous manifestation of neuropathy?

Post‐operative erythromelalgia treated with calcium channel blockers

Идиопатическая Манифестация Синдрома Митчелла (Эритромелалгии) У Ребенка

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